In vitro evaluation of dual agonists for PPARγ/β from the flower of Edgeworthia gardneri (wall.) Meisn

Gao, Die; Zhang, Yong-lan; Xu, Pan; Lin, Yexin; Yang, Feng‐Qing; Liu, Jianhui; Zhu, Hai-wen; Xia, Zhining

doi:10.1016/j.jep.2014.12.034

Cited by 25 publications

(22 citation statements)

References 35 publications

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“…Recently, researches have been focused on finding anti-obesity agents from natural products as that they have slight or no side effects. The flower of E.gardneri is widely used as Tibetan folk medicine for the treatment of metabolic diseases (Gao et al, 2015a). But the anti-obesity effect of the flower of E.gardneri has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

Gao

Zhang

Yang

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

Gao

Zhang

Yang

et al. 2016

Journal of Ethnopharmacology

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“…Though, the extracts reduced in the diabetes-induced renal damage related to the diabetic nephropathy [10]. Moreover, the extracts improved the effects of non-enzymatic and enzymatic antioxidants [11], also in vitro augmented the glycolytic activities [12]. These results propose a rationale for more studies utilizing combinations of the extracts and PDE-5 inhibitors in diabetes-induced ED.…”

Section: Discussionmentioning

confidence: 78%

Comparison of essential oils and antimicrobial activities of Ferulago mughlae Pe?men (Apiaceae) growing in Turkey

Karakaya¹,

Bostanlik²,

Göğer³

et al. 2018

jrp

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Ferulago species have been utilised since ancient times as antihelmentic, peptic, sedative and aphrodisiac, and as the seasoning in view of their special odors. In Turkish traditional medicine, the roots from some members of this genus are utilized as aphrodisiac, so we determined to show in vitro relaxant effect of F. mughlae Peșmen and F. sandrasica Peșmen & Quézel species extracts on corpus cavernosum (CC). A totality of 20 adult male Sprague-Dawley rats (diabetic and control groups) were induced by single intraperitoneal injection of 40 mg/kg of Streptozotocin. In vitro organ bath tests were carried out on rats to evaluate isometric pressure. Tissues were stretched with phenylephrine (Phe), and relaxation responses relevant to acetylcholine (ACh, 1 mM), sodium nitroprusside (SNP 0.1 µM) and electrical field stimulation (EFS, frequency 20 Hz) were gained. Whole these concentration-response curves were replicated with aqueous extracts obtained from the aerial parts and roots. The extracts were active in both groups. It was found that root extracts of F. mughlae and F. sandrasica yielded 97.80% and 97.55% relaxation. Among the extracts of roots (especially roots of F. mughlae) showed the best activity. On the other hand, lyophilized aqueous extracts of aerial part (especially F. sandrasica) showed the worst activity. Based on this findings, the roots of this species deserve further in vivo assessments for their aphrodisiac potential.

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“…12 Moreover, the treatment improved the activities of enzymatic and nonenzymatic antioxidants, 13 and also in vitro increased the glycolytic activities. 14 These results indicate a rationale for more studies using combinations of extracts and phosphodiesterase-5 inhibitors in diabetes-induced ED.…”

Section: Discussionmentioning

confidence: 89%

Effect of Extracts of the Aerial Parts and Roots from Four <i>Ferulago</i> Species on Erectile Dysfunction in Rats with Streptozotocin-Induced Diabetes

Karakaya¹,

Yilmaz‐Oral²,

Gür³

et al. 2019

tjps

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Amaç: Ferulago türlerine ait ekstreler Türkiye'de afrodizyak olarak kullanılmaktadır, bu nedenle in vivo ve in vitro olarak dört Ferulago türüne ait ekstrelerin korpus kavernosum (CC) üzerindeki gevşetici etkisini göstermeyi amaçladık. Gereç ve Yöntemler: Kontrol ve diyabetik gruba ayrılan toplam 30 yetişkin erkek Sprague Dawley sıçanı, 40 mg/kg Streptozotocin ile intraperitonal olarak tek seferlik enjeksiyon ile indüklenmiştir. Kavernosal sinirlerin uyarılmasıyla in vivo erektil yanıtlar elde edildi ve sıçanlarda intrakavernozal ekstraktların enjeksiyonu sonrasında tekrarlandı ve veriler intrakavernozal basınç (ICP)/ortalama arteriyel basınç ve toplam ICP olarak ifade edildi. CC striplerin gevşetici ve kasılma yanıtları, ekstraktların varlığında veya yokluğunda analiz edildi. Bulgular: Ekstraktların hem kontrol hem de diyabetik sıçanlar üzerinde aktif olduğu bulundu. Ekstraktlar (özellikle Ferulago bracteata kök metanol ekstresi) ile maksimum gevşeme yanıtları (%98.30±2.6) L-NAME (44.8±1.8) ile inkübasyondan sonra azalmıştır. ODQ, çözünebilir guanilat siklaz inhibitörü, kontrol sıçanlarından CC'de ekstraktların indüklediği maksimum gevşemenin %77'sini inhibe ettiği görülmüştür. Sonuç: Sonuç olarak bu türler erektil disfonksiyonda kullanılabilir ve sentetik ilaçlara karşı bitkisel alternatif oluşturabilir. Anahtar kelimeler: Afrodizyak, Apiaceae, Ferulago, erektil disfonksiyon Objectives: The extracts of Ferulago species are used as aphrodisiacs in Turkey and so we aimed to demonstrate in vivo and in vitro the relaxant effect of four Ferulago species' extracts on the corpus cavernosum (CC). Materials and Methods: A total of 30 adult male Sprague Dawley rats were divided into control and diabetic groups. Diabetes was induced by a single intraperitoneal injection of 40 mg/kg streptozotocin. In vivo erectile responses were obtained by stimulation of the cavernosal nerves and repeated after intracavernosal injection of extracts in rats, and the data were expressed as intracavernosal pressure (ICP)/mean arterial pressure and total ICP. The relaxant and contractile responses of CC strips were analyzed in the presence or absence of extracts. Results: The extracts were active in both control and diabetic rats. The extract-induced maximum relaxation responses (especially of methanol extract of the root of Ferulago bracteata) (98.30±2.6%) were decreased after incubation with L-NAME (44.8±1.8). ODQ, a soluble guanylate cyclase inhibitor, inhibited 77% of extract-induced maximum relaxation in the CC from the control rats. Conclusion: These species can be utilized in erectile dysfunction and may be an herbal alternative to synthetic drugs.

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In vitro evaluation of dual agonists for PPARγ/β from the flower of Edgeworthia gardneri (wall.) Meisn

Cited by 25 publications

References 35 publications

The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

The flower of Edgeworthia gardneri (wall.) Meisn. suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

Comparison of essential oils and antimicrobial activities of Ferulago mughlae Pe?men (Apiaceae) growing in Turkey

Effect of Extracts of the Aerial Parts and Roots from Four <i>Ferulago</i> Species on Erectile Dysfunction in Rats with Streptozotocin-Induced Diabetes

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