In-vitro/in-vivo evaluation of Paclitaxel Freeze-Dried micellar nanoparticles intended for buccal delivery

Ali, Ahmed Mahmoud Abdelhaleem; El-Enin, Hadel A. Abo

doi:10.1016/j.jddst.2021.102424

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…The organic solvent was allowed to evaporate overnight by slow magnetic stirring. After the complete removal of the organic solvent, the nanoparticles were centrifuged at 15000 rpm for 30 mins at −8 °C and washed three times with double distilled water ( Ali and El-Enin 2021 ). The nanoparticles were used freshly or freeze dried for further evaluation ( Mainardes and Evangelista 2005 ).…”

Section: Methodsmentioning

confidence: 99%

Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Sakhi¹,

Khan

et al. 2023

Saudi Pharmaceutical Journal

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Section: Methodsmentioning

confidence: 99%

Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Sakhi¹,

Khan

et al. 2023

Saudi Pharmaceutical Journal

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Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading

Zheng,

Wu,

Ahmad

et al. 2024

ACS Appl. Nano Mater.

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Lyophilization is a prevalent technique for preparing paclitaxel (PTX) clinical formulations. However, the instability of PTX nanoparticles poses challenges in producing lyophilized formulations. Such an instability involves maintaining stable dispersions and structural integrity during lyophilization. To tackle these issues, flash nanoprecipitation method is employed to prepare highly stable and loaded lyophilizable diPTX-SS nanoparticles, achieving over a month of nanosuspension stability and 91 wt % loading capacity. Furthermore, adjusting the concentrations and stabilizer ratios allows for controlled nanoparticle preparation with surface structures suitable for lyophilization. The hybridization of PLGA-PEG and DSPE-PEG increases the surface PEG layer content, creating a corona-like outer layer that maintains nanoparticle integrity during lyophilization, and ensures excellent redispersibility for postlyophilization without excessive cryoprotectants. Additionally, responsive release behavior, along with in vitro and in vivo experiments, confirms that these lyophilizable hybrid diPTX-SS nanoparticles effectively suppress tumor growth and vascular endothelial proliferation, offering insights for clinical PTX formulation development.

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Nanotechnology-Based Mucoadhesive and Mucus-Penetrating Drug-Delivery Systems for Transbuccal Drug Delivery

Desai,

Manikkath,

Lad

et al. 2023

Nanomedicine (Lond.)

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Buccal drug-delivery systems present a promising approach for the drug delivery to the buccal mucosa, addressing oral cavity-specific problems, enabling systemic delivery and minimizing adverse effects on biological systems. Numerous strategies have been proposed to load drug-containing nanoparticles (NPs) to the buccal mucosa for local and systemic applications. There has been considerable interest in the development of mucoadhesive buccal formulations, particularly hydrogel composites utilizing mucoadhesive films incorporating NPs. Drug permeability and controlled drug release through buccal drug delivery continues to pose a challenge despite the availability of various remedies. This review highlights the need for, mechanisms and latest advances in NP-based transbuccal drug delivery with a focus on various pathological disorders and examples and limitations of the different methods.

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In-vitro/in-vivo evaluation of Paclitaxel Freeze-Dried micellar nanoparticles intended for buccal delivery

Cited by 3 publications

References 46 publications

Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Effect of polymeric stabilizers on the size and stability of PLGA paclitaxel nanoparticles

Lyophilizable Polymer–Lipid Hybrid Nanoparticles with High Paclitaxel Loading

Nanotechnology-Based Mucoadhesive and Mucus-Penetrating Drug-Delivery Systems for Transbuccal Drug Delivery

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