In vitro Proliferation and Wound Healing Effects of Narcissus tazetta L. Bulb on Primary Human Dermal Fibroblasts

Rameshk, Maryam; Sharififar, Fariba; Mehrabani, Mitra; Pardakhty, Abbas; Farsinejad, Alireza

doi:10.9734/jpri/2017/39090

Cited by 10 publications

(8 citation statements)

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“…PEN after 24 h at 1.562, 3.125 μg/ml concentrations and after 48 h at 1.562 to 6.25 μg/ml concentrations significantly ( p < 0.05) decreased the gap width compared to the control. The results of the effectiveness of PEN on gap width were approximately agreement with the results of the previous study in this field [24]. In comparison, F9 caused significant reduction in gap width to the PEN.…”

Section: Discussionsupporting

confidence: 90%

“…In the final step of this study, we compared the effect of PEN and F9 on gap width and proliferation of fibroblast cells. In the previous study, PEN had no significant effect on proliferation of fibroblast cells [24]. Results of Kern study [44] revealed that cosmetic creams containing processed N. tazetta bulb extract caused cell proliferation reduction and cell growth inhibition of human fibroblasts and keratinocytes in primary cultures.…”

Section: Discussionmentioning

confidence: 96%

“…Since in vitro wound healing effect of Zaroor extract of N. tazetta was evaluated in pervious study [24], the aim of this study was preparation niosomal formulation, as a new drug delivery, of N. tazetta bulb and evaluation of particle size, encapsulation percentage, in vitro release study of encapsulated material, and stability of it along three months and effectiveness of this formulation on human dermal fibroblasts. To our knowledge, there is no previous report on the production and usage of niosomal formulation of N. tazetta bulb on wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

et al. 2018

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

et al. 2018

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“…Colorimetric method was used to measure the amounts of total flavonoids in the plant [31] . For this purpose, different concentration of rutin and quercetin standard (500-62 μg/mL) was prepared in methanol 60%.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

Hasheminasab

Azimi

Khodadoost

et al. 2022

Advances in Integrative Medicine

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“…While Narcissus tazetta L. with the common name of "Narjes"have many medicinal uses due to containing many active constituents as secondary metabolites as alkaloids, the plant bulb is recommended for treatment of wounds and inflammation which has reported in traditional medicine of Turkey ,Persian , China, and Jordan, [14]. The bulb extract represents an interesting active ingredient and many researchers indicate that, narcissus could be used as anti-viral, anti-fungal, anti-tumor and many other uses [15,16].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Genotoxicity Enhancement of the Antileukemic Drug 6-Mercaptopurin When Combined With Iraqi Nerium oleander and Narcissus tazetta Extracts in vivo

Mohammed¹,

Ahmed²

2018

JoBRC

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The present study was aimed to evaluate the genotoxicity of the aqueous extracts of Nerium oleander leaves and Narcissus tazetta bulbs each alone and together with the antileukemic drug 6-Mercaptopurin (6MP) in order to investigate the extracts ability to elevate the chemotherapeutic drug genotoxicity which may influence its treatment of cancer. The cytotoxicity test shows that the LD50 of the aqueous extract of Narcissus tazetta was 752.083 mg/kg and for Nerium oleander was 922.023 mg/kg. On the basis of the achieved LD50 values, the doses 92, 46 ,23 mg/kg of Nerium oleander and the doses 75, 37,18 mg/kg of Narcissus tazetta extracts were chosen, depending on chromosome aberrations, Micronuclei and Mitotic index as a powerful cytogenetic assays in bone marrow cells of Swiss albino male mice. The result indicated that Nerium oleander extract alone at the dose 92mg/kg induced significant effect on centromere break and ring chromosome comparing with the negative control (untreated mice) and significantly increased the mean values of chromatid gap and ring chromosome when compared with the positive control ( 6MP ). While only the dose 46 mg/kg and 23 mg/kg of N. oleander aqueous extracts significantly decreased mitotic index and when combined with 6MP it can enhance its antimitotic activity but not significantly. Moreover the extracts alone and when combined with 6MP did not significantly change the total number of red blood micro nucleated cells. For Narcissus tazetta extract, the three experimental doses alone lead to significant increase in chromosomal aberrations like: chromatid break with fragment, chromatid break without fragment, chromatid gap, centromeric break, ring chromosome and dicentric chromosome. While only the dose 75mg/kg had induced significant structural chromosomal abnormalities such as chromatid break with fragment, chromatid break without fragment centromeric break and ring chromosome, when combined with 6MP. The three doses of N. tazetta extract alone, had led to significant reduction in mitotic index compared with untreated control and also its combination with 6-MP significantly decreased the percentage of mitotic index. Moreover, only the doses 75 mg/kg and 37 mg/kg of N. tazetta extracts, when had given alone caused significant increase of the total micronucleated cells. While only the dose 75mg/kg of N. tazetta had induced significant frequency of the total micronucleated cell when combined with 6MP. In the present report, we attempted to establish that N.tazetta and Nerium oleander aquatic extracts enhance the genotoxicity and bioactivity induced by the antileukemic drug 6MP , thus preventing the development of cellular drug resistance which is a major problem that can face cancer patients using this drug .The current study serve the purpose of which is to search for local plants that may contribute to the establishment of novel supportive complementary and alternative medicine (CAM) during the chemotherapy of cancer in Iraq , Further studies are merited to explore this possibility.

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In vitro Proliferation and Wound Healing Effects of Narcissus tazetta L. Bulb on Primary Human Dermal Fibroblasts

Cited by 10 publications

References 0 publications

Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

Proliferation and In Vitro Wound Healing Effects of the Microniosomes Containing Narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs)

Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

Evaluating the Genotoxicity Enhancement of the Antileukemic Drug 6-Mercaptopurin When Combined With Iraqi Nerium oleander and Narcissus tazetta Extracts in vivo

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