In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. &amp; Thonn.) Müll. Arg. (Euphorbiaceae)

Manga, Hélène Mavar; Brkic, Dejand; Marie, Daniel; Quetin-Leclercq, Joëlle

doi:10.1016/j.jep.2004.02.019

Cited by 84 publications

(40 citation statements)

References 19 publications

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“…The literature indicates that other species of the Alchornea genera present anti-inflammatory activity. 7 Our results agree closely with those published by Repetto and Llesuy, 28 which showed that phenolic compounds have a dual effect on PG biosynthesis, since low concentrations stimulate whereas high concentrations inhibit PGH synthase. Thus, the action mechanism possibly involves the modulation of endogenous PGs by active constituents contained in ME.…”

supporting

confidence: 93%

“…6 In contrast, other species of this genus already have been subjects of pharmacological studies: Alchornea cordifolia presented an anti-inflammatory property, whereas Alchornea castaneaefolia and Alchornea glandulosa exhibited an anti-ulcer action. [7][8][9] Ebi 10 determined that methano-lic extract (ME) of A. cordifolia also showed antimicrobial activity against Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.…”

Section: Introduction Pmentioning

confidence: 99%

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Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

Lima

Calvo

Silva

et al. 2008

Journal of Medicinal Food

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Among the current treatment strategies for the peptic ulcer patient with Helicobacter pylori infection, the method of choice is triple therapy based on the concurrent use of proton inhibitors and two antibiotics. Alchornea triplinervia is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. In the present work we proposed therapy based on this medicinal plant that presents effective gastroprotective action with antibiotic effects. Oral pretreatment with methanolic extract (ME) of A. triplinervia in rats and mice decreased the gastric injuries induced by ethanol and HCl/ethanol. Increasing the dose reduced the gastroprotective effects of ME on the gastric lesions induced by nonsteroidal anti-inflammatory drug. After pylorus ligature of mice, oral administration of ME induced a decrease not only in total acid but also in the ulcer index. We also observed that ME displayed antibacterial activity against H. pylori. Liquid-liquid separation of ME indicated that active constituents responsible for the gastroprotective action are concentrated in the ethyl acetate fraction (EAF) (50% protection) rather than in the aqueous fraction, which did not induce significant gastroprotection at the same dose (100 mg/kg). EAF induced an increase of gastric mucosa prostaglandin (PG) E 2 levels, which remained high even after previous administration of indomethacin. The phytochemical profile of ME revealed that EAF contains mainly flavonoids. In conclusion, all these results suggest that ME did not show acute toxicity, but exhibited an antisecretory property, anti-H. pylori effect, and gastroprotective action. The observed effect did not involve the participation of nitric oxide or endogenous sulfhydryl groups. However, EAF showed a more efficient gastroprotective effect than ME at a lower dose and protected the gastric mucosa by increasing PGE 2 .

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supporting

confidence: 93%

Section: Introduction Pmentioning

confidence: 99%

Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

Lima

Calvo

Silva

et al. 2008

Journal of Medicinal Food

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“…To evaluate the effect of H. cheirifolia methanol extract on acute inflammation, croton oil-induced ear oedema was performed according to Manga et al (2004). Cutaneous inflammation was induced in the inner surface of the right ear of mice (6 mice/ group) by application of 15 lL of acetone containing 80 lg of croton oil as irritant.…”

Section: Croton Oil-induced Ear Oedema In Micementioning

confidence: 99%

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

Bouriche

Kada

Assaf

et al. 2016

Pharmaceutical Biology

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Context: Hertia cheirifolia L. (Asteraceae) is traditionally used in Northern Africa to treat various inflammatory infections. However, few studies on this plant have been reported. Objective: The anti-inflammatory activity of methanol extract of H. cheirifolia leaves was investigated using different experimental models. Materials and methods: Phytochemical analysis was performed to determine phenolic compounds. Acute toxicity of the extract (2000 mg/kg) was examined in Swiss albino mice for 14 days, before croton oilinduced ear oedema in mice, carrageenan-induced paw oedema in Swiss albino rats, cotton pellet-induced granuloma in rats and carrageenan-induced air pouch in mice were conducted. The IL-1b and TNF-a release from concanavalin A-stimulated monocytes was measured by ELISA. Results: Methanol extract of H. cheirifolia is rich in polyphenols and flavonoids. Cinnamic acid and rutin represent the major constituents. Methanol extract up to 2000 mg/kg did not produce any toxic effects. Topical application of 2 mg/ear of the extract produced 78.7% of inhibition on ear swilling. Oral pre-treatment of rats with 200 and 400 mg/kg of the extract inhibited paw oedema by 70% and 89%, respectively. At 200 mg/kg, granuloma dry and wet weights were reduced by 41.85% and 61.72%, respectively. Moreover, the treatment with methanol extract at 1 mg/kg exerted 62.7% of inhibition on leucocytes migrated into the ear pouch. TNF-a and IL-1b release was reduced by 69% and 78%, respectively, with 1 lg/mL of the extract. Conclusion: Methanol extract of H. cheirifolia possesses a strong anti-inflammatory activity and may be considered an interesting source of effective anti-inflammatory compounds.ARTICLE HISTORY

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“…Les résultats obtenus à l'issue des tests anti-inflammatoires montrent que les extraits aqueux d'Alchornea cordifolia et de Mangifera indica réduisent de façon appréciable l'oedème induit par la caraghénine, entre la 1 ère heure et la 4 e heure (Aouissa, 2002 ;Osadebe et al, 2003 ;Mavar et al, 2004). Les effets des extraits aqueux d'Alchornea cordifolia et de Mangifera indica tendent à s'estomper avec le temps comme (Gabino et al, 2001 ;Aouissa, 2002 ;Mavar et al, 2004 ;Ojewole, 2005). L'oedème a été provoqué par la carraghénine dans la patte de la souris ou du rat.…”

Section: Introductionunclassified

“…Les médicaments anti-inflammatoires interviennent en général en s'opposant à l'effet de ces médiateurs chimiques: histamine, sérotonine, kinines et prostaglandines. L'inhibition importante du gonflement de la patte par Alchornea cordifolia et Mangifera indica entre la première et la troisième heure montre que celle-ci a un effet sur les trois phases et donc sur les médiateurs tels que l'histamine, la 5-hydroxytryptamine, les kinines et les prostaglandines (Aouissa, 2002 ;Mavar et al, 2004 …”

Section: Introductionunclassified

Étude phytochimique et pharmacologique d’<i>Alchornea cordifolia</i> (Schum. & Thonn.) Mull. Arg. et de <i>Mangifera indica</i> dans le traitement traditionnel de la maladie hémorroïdaire

Nga¹,

Yinyang²,

Bidias³

et al. 2017

J. App. Bioscience.

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The plant material was collected and prepared by aqueous decoction. The phytochemical study of extracts resulted firstly by characterizing secondary metabolites revealed by the tests of phytochemical screening and secondly by the assay by the method flavonoids aluminum trichloride. Animal material (rats and female mice) was prepared for the pharmacological study. The reducing activity of the free radical 2,2-diphenyl-1-picrylhydrazine extracts, the acute toxicity limits tests on female mice and determination of anti-inflammatory activity in vivo extracts taken along the induction method edema by carrageenin in female rats. The tannins and flavonoids were revealed in the aqueous extracts. The contents of Alchornea cordifolia and Mangifera indica Flavonoids are 241 and 194 mg equivalent of catechin respectively. The CE 50 extracts showed an antioxidant (0.02 mg/ml and 0.03 mg/ml) relatively low compared to the ascorbic acid with an CE 50 of 0.003 50 mg/ml. The safety of aqueous extracts of Alchornea cordifolia and Mangifera indica is demonstrated for DL 50> 5000 mg/ ml. The anti-inflammatory test with 500 mg/kg and 1000 mg/kg of extracts confirmed the inhibitory power of the extracts on inflammatory mediators : histamine, 5-hydroxytryptamine, kinins and prostaglandins. Conclusion and application of the Results:The rich aqueous extracts of Alchornea cordifolia and Mangifera indica polyphenolic constituents capable of trapping free radicals and increasing venous tone, also prevent the formation of mediators that cause inflammation.

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In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. (Euphorbiaceae)

Cited by 84 publications

References 19 publications

Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

Brazilian Medicinal Plant Acts on Prostaglandin Level andHelicobacter pylori

Phytochemical screening and anti-inflammatory properties of AlgerianHertia cheirifoliamethanol extract

Étude phytochimique et pharmacologique d’<i>Alchornea cordifolia</i> (Schum. & Thonn.) Mull. Arg. et de <i>Mangifera indica</i> dans le traitement traditionnel de la maladie hémorroïdaire

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