In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits

Duta, L.; Neamțu, Johny; Melinte, Razvan; Zureigat, Oana A.; Popescu-Pelin, Gianina; Chioibasu, Diana; Oktar, Faik N.; Popescu, Andrei C.

doi:10.3390/coatings10100992

Cited by 13 publications

(18 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditional production methods are difficult to realize the processing of complex structures [13][14][15]. Recently, the technology of additive manufacturing(AM) can perfectly solve the problem that complex parts are difficult to produce [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Review on Additive Manufacturing of Pure Copper

et al. 2021

View full text Add to dashboard Cite

With the development of the aerospace and automotive industries, high heat exchange efficiency is a challenge facing the development of various industries. Pure copper has excellent mechanical and physical properties, especially high thermal conductivity and electrical conductivity. These excellent properties make pure copper the material of choice for the manufacture of heat exchangers and other electrical components. However, the traditional processing method is difficult to achieve the production of pure copper complex parts, so the production of pure copper parts through additive manufacturing has become a problem that must be overcome in industrial development. In this article, we not only reviewed the current status of research on the structural design and preparation of complex pure copper parts by researchers using selective laser melting (SLM), selective electron beam melting (SEBM) and binder jetting (BJ) in recent years, but also reviewed the forming, physical properties and mechanical aspects of pure copper parts prepared by different additive manufacturing methods. Finally, the development trend of additive manufacturing of pure copper parts is also prospected.

show abstract

Section: Introductionmentioning

confidence: 99%

A Review on Additive Manufacturing of Pure Copper

et al. 2021

View full text Add to dashboard Cite

show abstract

“…However, this method requires many steps and high temperature, and there is an organic residue. Other methods include electrostatic and covalent attachment [ 32 ], electrophoretic deposition [ 18 ], electrochemical deposition [ 33 ], biomimetic precipitation [ 34 ], physical vapor deposition techniques [ 35 , 36 ], and plasma spraying [ 37 ], among others. However, the coatings obtained using these methods have a thickness measured in micrometers and a non-porous structure.…”

Section: Introductionmentioning

confidence: 99%

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

et al. 2021

View full text Add to dashboard Cite

Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants.

show abstract

“…In vitro tests play key-roles in the overall evaluation of a biomaterial by delivering important information on its potential behavior inside a living system. To better understand the complex processes occurring in a living environment and to deliver accurate data for the validation of the biomaterials' performances that target clinical trials, in vivo tests (using either animal or human models) are of key-importance and should, therefore, follow thorough in vitro acceptance [75].…”

Section: In Vivo Assessment Of Pld Cap-based Coatingsmentioning

confidence: 99%

“…The rabbit's bones manifest faster changes as compared to the case of larger animal models [115]. Considering the difficulties met when extrapolating the results obtained on rabbit bones to the human case, various screenings for implant design and validation of the tested materials are still needed to be performed [75], before their testing on larger animal models. Dog models are generally used for testing dental implants [116].…”

Section: Animal and Human Implant Modelsmentioning

confidence: 99%

In Vivo Assessment of Synthetic and Biological-Derived Calcium Phosphate-Based Coatings Fabricated by Pulsed Laser Deposition: A Review

Duta

2021

Coatings

Self Cite

View full text Add to dashboard Cite

The aim of this review is to present the state-of-the art achievements reported in the last two decades in the field of pulsed laser deposition (PLD) of biocompatible calcium phosphate (CaP)-based coatings for medical implants, with an emphasis on their in vivo biological performances. There are studies in the dedicated literature on the in vivo testing of CaP-based coatings (especially hydroxyapatite, HA) synthesized by many physical vapor deposition methods, but only a few of them addressed the PLD technique. Therefore, a brief description of the PLD technique, along with some information on the currently used substrates for the synthesis of CaP-based structures, and a short presentation of the advantages of using various animal and human implant models will be provided. For an in-depth in vivo assessment of both synthetic and biological-derived CaP-based PLD coatings, a special attention will be dedicated to the results obtained by standardized and micro-radiographies, (micro) computed tomography and histomorphometry, tomodensitometry, histology, scanning and transmission electron microscopies, and mechanical testing. One main specific result of the in vivo analyzed studies is related to the demonstrated superior osseointegration characteristics of the metallic (generally Ti) implants functionalized with CaP-based coatings when compared to simple (control) Ti ones, which are considered as the “gold standard” for implantological applications. Thus, all such important in vivo outcomes were gathered, compiled and thoroughly discussed both to clearly understand the current status of this research domain, and to be able to advance perspectives of these synthetic and biological-derived CaP coatings for future clinical applications.

show abstract

In Vivo Assessment of Bone Enhancement in the Case of 3D-Printed Implants Functionalized with Lithium-Doped Biological-Derived Hydroxyapatite Coatings: A Preliminary Study on Rabbits

Cited by 13 publications

References 59 publications

A Review on Additive Manufacturing of Pure Copper

A Review on Additive Manufacturing of Pure Copper

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method

In Vivo Assessment of Synthetic and Biological-Derived Calcium Phosphate-Based Coatings Fabricated by Pulsed Laser Deposition: A Review

Contact Info

Product

Resources

About