2018
DOI: 10.1155/2018/4560647
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In Vivo Release of Vancomycin from Calcium Phosphate Cement

Abstract: Calcium phosphate cement (CPC) has good release efficiency and has therefore been used as a drug delivery system for postoperative infection. The release profile of CPC has mainly been evaluated by in vitro studies, which are carried out by immersing test specimens in a relatively large amount of solvent. However, it remains unclear whether antibiotic-impregnated CPC has sufficient clinical effects and release in vivo. We examined the in vivo release profile of CPC impregnated with vancomycin (VCM) and compare… Show more

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Cited by 14 publications
(11 citation statements)
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“…In a work from 2018 by Uchida et al [ 40 ], a comparison between the release of vancomycin from CPC and from non-biodegradable poly(methyl methacrylate) (PMMA) was reported for both in vitro and in vivo conditions. In the in-vitro experiment, the drug release was consistently more copious from the CPC carrier than from the PMMA one and this difference in release increased constantly with time for 56 days.…”
Section: General Matrix Featuresmentioning
confidence: 99%
See 1 more Smart Citation
“…In a work from 2018 by Uchida et al [ 40 ], a comparison between the release of vancomycin from CPC and from non-biodegradable poly(methyl methacrylate) (PMMA) was reported for both in vitro and in vivo conditions. In the in-vitro experiment, the drug release was consistently more copious from the CPC carrier than from the PMMA one and this difference in release increased constantly with time for 56 days.…”
Section: General Matrix Featuresmentioning
confidence: 99%
“…In a work by Uchida et al from 2018 [ 40 ], an interesting comparison between systems for the local delivery of vancomycin was proposed. The compared scaffold systems consisted either of a CPC of or PMMA.…”
Section: In Vivo Releasementioning
confidence: 99%
“…Recently, Kentaro and his colleagues tested calcium phosphate cement (CPC) as a releasing and delivery material for a vancomycin antibiotic comparative to that of standard polymethylmethacrylate (PMMA) cement. They reported that calcium phosphate cement released more vancomycin both in vivo and in vitro for a longer time than PMMA, hence it can be used as an appropriate material for releasing antibiotics against postoperative infection [35].…”
Section: Non-viral Delivery Systemsmentioning
confidence: 99%
“…During the gradual degradation process, the antibiotic could be released to achieve a high topical concentration so that the bone tissue could grow into and replace the osseous defects in the infective site (Ferguson et al, 2014). Although antibiotic‐loaded CPC could release greater amounts of antibiotics than PMMA, CPC was weak in mechanical strength, attributing to the disintegration during the setting period (Uchida et al, 2018). Our previous studies showed that the mechanical properties of CPC could be enhanced by incorporation of chitosan (Chen et al, 2013).…”
Section: Introductionmentioning
confidence: 99%