Inactivation of SARS-CoV-2 by commercially available alcohol-based hand sanitizers

Leslie, Rachel A.; Zhou, Sifang; Macinga, David R.

doi:10.1016/j.ajic.2020.08.020

Cited by 81 publications

(64 citation statements)

References 7 publications

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“…While chemical disinfectants and alcohols are effective methods of inactivating SARS-CoV-2 in most circumstances, disinfection of large spaces using these methods is a laborious process requiring close contact with potentially contaminated surfaces [ 25 , 26 , 27 , 28 ]. UV light has long been established as an effective and direct method for the inactivation of enveloped viruses [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material

Jureka

Williams

Basler

2021

Viruses

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The ongoing SARS-CoV-2 pandemic has resulted in an increased need for technologies capable of efficiently disinfecting public spaces as well as personal protective equipment. UV light disinfection is a well-established method for inactivating respiratory viruses. Here, we have determined that broad-spectrum, pulsed UV light is effective at inactivating SARS-CoV-2 on multiple surfaces in vitro. For hard, non-porous surfaces, we observed that SARS-CoV-2 was inactivated to undetectable levels on plastic and glass with a UV dose of 34.9 mJ/cm2 and stainless steel with a dose of 52.5 mJ/cm2. We also observed that broad-spectrum, pulsed UV light is effective at reducing SARS-CoV-2 on N95 respirator material to undetectable levels with a dose of 103 mJ/cm2. We included UV dosimeter cards that provide a colorimetric readout of UV dose and demonstrated their utility as a means to confirm desired levels of exposure were reached. Together, the results presented here demonstrate that broad-spectrum, pulsed UV light is an effective technology for the in vitro inactivation of SARS-CoV-2 on multiple surfaces.

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Section: Introductionmentioning

confidence: 99%

Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material

Jureka

Williams

Basler

2021

Viruses

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“…3Ca, b). This compares very favorably to 70% ethanol, the disinfectant regarded as the standard, which achieved a 3 log 10 reduction of SARS-CoV-2 after 30 seconds, 7 and a 2 log 10 reduction of feline calicivirus after one minute. 8…”

Section: Main Textmentioning

confidence: 71%

Rapidly self-sterilizing PPE capable of 99.9% SARS-CoV-2 deactivation in 30 seconds

Aa¹,

Izadjoo²,

Kim³

et al. 2020

Preprint

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The Coronavirus disease 2019 (COVID-19) has created an acute worldwide demand for sustained broadband pathogen suppression in households, hospitals, and public spaces. Infections have surged past 160,000 daily new cases in the US, the highest rates yet seen during the pandemic. In response, we have created a rapid-acting, self-sterilizing PPE configurations capable of killing SARS-CoV-2 and other microbes in seconds. The highly active material destroys pathogens faster than any conventional copper configuration. The material maintains its antimicrobial efficacy over sustained use and is shelf stable. We have performed rigorous testing in accordance with guidelines from U.S. governing authorities and believe that the material could offer broad spectrum, non-selective defense against most microbes via integration into masks and other protective equipment.SummaryA novel configuration of copper offers continued fast-acting protection against viruses and bacteria, including SARS-CoV-2.

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“…Disinfection technologies at indoor environments are one of the key elements in avoiding the spreads of COVID-19, particularly for medical doctors and front-line healthcare workers in hospital [16]. Most liquid biocides such as ethanol, sodium hypochlorite and electrolyzed water demonstrate prompt anti-SARS-CoV-2 activity [5,17]; however, those virucidal effects are short-term and become inactivated once contaminated with certain organic substances. By contrast, the photocatalytic techniques are expected to show relatively moderate but long-term virucidal activity because they are renewable [18].…”

Section: Resultsmentioning

confidence: 99%

Photocatalyst under visible light irradiation inactivates SARS-CoV-2 on an abiotic surface

Uema¹,

Yonemitsu²,

Momose³

et al. 2020

Preprint

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There is a worldwide attempt to develop prevention strategies against SARS-CoV-2 transmission. Here we examined the effectiveness of visible light-responsive photocatalyst RENECAT on the inactivation of SARS-CoV-2 under different temperatures and exposure durations. The viral activation on the photocatalyst-coated glass slides decreased from 5.93∓0.38 logTCID50/ml to 3.05∓ 0.25 logTCID50/ml after exposure to visible light irradiation for 6h at 20 degree C. On the other hand, lighting without the photocatalyst, or the photocatalyst-coat without lighting retained viral stability. Immunoblotting and electron microscopic analyses showed the reduced amounts of spike protein on the viral surface after the photocatalyst treatment. Our data suggest a possible implication of the photocatalyst on the decontamination of the SARS-CoV-2 in indoor environments, thereby preventing indirect viral spread.

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Inactivation of SARS-CoV-2 by commercially available alcohol-based hand sanitizers

Cited by 81 publications

References 7 publications

Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material

Pulsed Broad-Spectrum UV Light Effectively Inactivates SARS-CoV-2 on Multiple Surfaces and N95 Material

Rapidly self-sterilizing PPE capable of 99.9% SARS-CoV-2 deactivation in 30 seconds

Photocatalyst under visible light irradiation inactivates SARS-CoV-2 on an abiotic surface

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