Incorporation of Complete Phospholipid Molecules in Cellular Membranes of Rat Liver after Uptake from Blood Serum

Lekim, Dac; Betzing, H; Stoffel, Wilhelm

doi:10.1515/bchm2.1972.353.1.949

Cited by 35 publications

(3 citation statements)

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“…Amphibian liver is equipped with the necessary enzymes to perform lipid biosynthesis (7) and, during ovulation, the transfer from the liver into the ovaries of lipophosphoproteins takes place (8). The uptake of entire phospholipids from the blood stream does, in fact, occur in cellular membranes of rat tissues (9). Until late gastrulation, U -14C glycerol uptake into lipids does not take place.…”

Section: Discussionmentioning

confidence: 99%

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

Pechèn

Bazán

1977

Lipids

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Embryos of the toad, Bufo arenarum, Hensel, taken during early stages of development were used to survey the [U-14C]glycerol and 32P lipid labeling. When precursors were supplied at the time of oogenesis, large differences in specific activities of phospholipid were observed. Using 32P, a steep rise as a function of development was evidenced. Triglycerides contained much higher proportions of [U-14C] glycerol than phospholipids when administered to the female toad along with a pituitary homogenate. However, lack of [U-14 C] glycerol uptake into lipids was observed when cell-free homogenates of eggs at different stages of development ranging from unfertilized oocyte to midgastrula were incubated in unsupplemented amphibian Ringer. At the later stage, significant de novo biosynthesis of lipids from glycerol began to be measurable, whereas during cell cleavage intracellular redistribution of preformed phosphoglycerides was used for membrane assembly.

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Section: Discussionmentioning

confidence: 99%

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

Pechèn

Bazán

1977

Lipids

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“…Our data implicate that DLPC acts synergistically with SAMe in the replenishment of GSH that was depleted in response to leptin treatment. DLPC (and its parent compound PPC) have high bioavailability and capacity for incorporating into cell membranes (41). As such, they could play a role in the repair of oxidative damage of phosphatidylcholines (PCs), the backbone of cell membranes.…”

Section: Discussionmentioning

confidence: 99%

DLPC and SAMe combined prevent leptin‐stimulated TIMP‐1 production in LX‐2 human hepatic stellate cells by inhibiting H₂O₂‐mediated signal transduction

Cao

Mak

Lieber

2006

Liver International

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“…Orally administered polyunsaturated phosphatidyl choline (P.P.C.)' has both a membrane-stabilising and an antihepatotoxic effect (9). Experimental studies in animals have shown that the basic constituent ' "Essential Phospholipid", Nattermann & Cie, Germany.…”

mentioning

confidence: 99%

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double‐blind controlled trial

Jenkins

Portmann

Eddleston

et al. 1982

Liver

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ABSTRACT— In a prospective double‐blind trial, polyunsaturated phosphatidyl choline therapy (3 g/day) was given in addition to normal maintenance immunosuppressive therapy to 15 patients with HBsAg negative chronic active hepatitis. Histological evidence of disease activity was significantly reduced in the phospholipid‐treated group. The results indicate that polyunsaturated phosphatidyl choline is of value as additional treatment in the management of patients with HBsAg negative chronic active hepatitis whose disease is inadequately controlled with conventional doses of immunosuppressive therapy.

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Incorporation of Complete Phospholipid Molecules in Cellular Membranes of Rat Liver after Uptake from Blood Serum

Cited by 35 publications

References 1 publication

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

DLPC and SAMe combined prevent leptin‐stimulated TIMP‐1 production in LX‐2 human hepatic stellate cells by inhibiting H₂O₂‐mediated signal transduction

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double‐blind controlled trial

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Incorporation of Complete Phospholipid Molecules in Cellular Membranes of Rat Liver after Uptake from Blood Serum

Cited by 35 publications

References 1 publication

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

Lipid metabolism in early development using labeled precursors incorporated during oogenesis and in cell‐free embryo homogenates

DLPC and SAMe combined prevent leptin‐stimulated TIMP‐1 production in LX‐2 human hepatic stellate cells by inhibiting H2O2‐mediated signal transduction

Use of polyunsaturated phosphatidyl choline in HBsAg negative chronic active hepatitis: results of prospective double‐blind controlled trial

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DLPC and SAMe combined prevent leptin‐stimulated TIMP‐1 production in LX‐2 human hepatic stellate cells by inhibiting H₂O₂‐mediated signal transduction