Infected wound healing and antimicrobial effects of Chenopodium ambrosioides and Mitracarpus scaber

Abstract

Chenopodium ambrosioides Linn. (Chenopdiaceae) and Mitracarpus scaber Zucc. (Rubiaceae) are herbal medicinal plants. They are commonly used in Togolese folk medicine to treat skin infections such as infected wounds, dermatoses, and scabies. The aim of this work was to evaluate the wound healing and antimicrobial properties of the two plants. Firstly, we evaluated the infected wound healing property of the two plants. We induced and treated infected wound in Wistar rats as follows. We inserted a sterile needle under the skin of the animal previously anesthetized by ether. Along the needle, we made an incision of 2 cm of length. The wound was infected with 24 hours colonies of P.aeruginosa. One infected wound was created per animal. 0.5 g of ointments prepared form C. ambrosioides and M. scaber leaf extracts, was applied twice a day. Secondly, we conducted antimicrobial assays with extracts prepared with the leaves of the plants. Staphylococcus aureus, Pseudomonas aeruginosa, Candida albcans, Escherichia coli and Salmonella sp. were used in this study. Infected wound in control group healed in 12.6±0.245 days. The ointment from C. ambrosioides or M. scaber leaf extracts, significantly and respectively reduced this mean time to 07.04±0.245 (P<0.01) and 06.4±0.245 (P<0.01) days. The extracts showed antimicrobial activities against all tested strains. C. ambrosioides and M. scaber possess wound healing and antimicrobial properties. These findings support their traditional use in treatment of skin infections.

Phytochemical Screening, Antimicrobial and Antioxidant Activities of Aloe buettneri, Mitracarpus scaber and Hannoa undulata used in Togolese Cosmetopoeia

“…C. acnes promotes NLRP3inflammasome via IL-1β release in vitro in monocytemacrophages and in vivo in mice 9 . C. acnes also stimulates the expression of tumors necrosis factor-α (TNF-α) receptors, Toll-like receptors (TLRs), interferon (IFN), matrix ISSN: 2250-1177 [20] CODEN (USA): JDDTAO metalloproteinases and interleukins (IL-1, IL-8, IL-6, IL-12) by keratinocytes, leading to inflammation and hyperkeratinisation of the pilosebaceous tissue 10 . Current research has shown that the imbalance of the fascial skin micro-organism in acne vulgaris 11 .…”

“…Aloe buettneri, Mitracarpus scaber and Hannoa undulata are used in the Togolese cosmetopoeia and to treat dermatosis. Their pharmacological studies have revealed some interesting properties that would help relieve acne sufferers: Aloe buettneri for its antioxidant and gastric antisecretory effects 16 , anti-ulcer and anti-inflammatory effects 17,18 ; Mitracarpus scaber for its antimicrobial and antiradical effects 19 , infected wound healing activities 20 and Hannoa undulata for also its antimicrobial activities 21 . In the present study, investigations were conducted on the in vitro anti-oxidant and anti-microbial activities on acne-induicing micro-organisms of Aloe buettneri, Mitracarpus scaber and Hannoa undulata.…”

Phytochemical Study and Comparative Antioxidant Activity of Extracts from Aerial Parts of &lt;i&gt;Chenopodium ambrosioides&lt;/i&gt; Linn. (Chenopodiaceae)

“…More precisely in Togo, the aerial parts (leaves and seeds) of Chenopodium ambrosioides are used for making herbal teas to treat several pathologies: inflammation, malaria, abdominal pain, digestive parasitosis. The plant is commonly used in traditional medicine in Togo in the treatment of abscesses and infected wounds [4].…”