Influence of aptamer-targeted antibiofilm agents for treatment of Pseudomonas aeruginosa biofilms

Wang, Sheng; Mao, Biyao; Ming-xi, WU; Liang, Jingjing; Deng, Le

doi:10.1007/s10482-017-0941-4

Cited by 36 publications

(24 citation statements)

References 28 publications

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“…Therefore, aptamers can offer a tremendous opportunity for effective treatment of chronic infection, and also, serve a better eradication of biofilm formation bacteria. In general, using aptamers with anti-biofilm activity can lessen the dose and duration of antibiotic therapy in chronic and resistant infections, thus, reduce the risk of abuse and misuse of antibiotic administration [43].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic applications of nucleic acid aptamers in microbial infections

et al. 2020

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Today, the treatment of bacterial infections is a major challenge, due to growing rate of multidrug-resistant bacteria, complication of treatment and increased healthcare costs. Moreover, new treatments for bacterial infections are limited. Oligonucleotide aptamers are single stranded DNAs or RNAs with target-selective high-affinity feature, which considered as nucleic acid-based affinity ligands, replacing monoclonal antibodies. The aptamer-based systems have been found to be talented tools in the treatment of microbial infections, regarding their promising anti-biofilm and antimicrobial activities; they can reduce or inhibit the effects of bacterial toxins, and inhibit pathogen invasion to immune cell, as well as they can be used in drug delivery systems. The focus of this review is on the therapeutic applications of aptamers in infections. In this regard, an introduction of infections and related challenges were presented, first. Then, aptamer definition and selection, with a brief history of aptamers development against various pathogens and toxins were reviewed. Diverse strategies of aptamer application in drug delivery, as well as, the effect of aptamers on the immune system, as the main natural agents of human defense against pathogens, were also discussed. Finally, the future trends in clinical applications of this technology were discussed.

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Section: Introductionmentioning

confidence: 99%

Therapeutic applications of nucleic acid aptamers in microbial infections

et al. 2020

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“…As a new strategy for biofilm control, Wang et al, 2018 [35], conjugated their previously described aptamer against P. aeruginosa (PA-ap1) [15] with ciprofloxacin (CPX), enhancing the efficiency of antibiofilm agents. P. aeruginosa was considered as a model organism due to its strong biofilm formation ability and for developing high resistance, as many drugs cannot diffuse into the biofilm.…”

Section: Resultsmentioning

confidence: 99%

Application of aptamer technology in enterobacteria and non-fermenters: literature review

Bes

Farrel

Santos³

et al. 2022

Preprint

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Antimicrobial resistance has grown exponentially in the last decade and become a global health threat. The antibiotic resistance crisis has guided the scientific community to explore non-conventional interventions to target resistant bacteria. Development of new technologies, such as aptamers-based treatment and diagnosis, has shown to be promising with remarkable advantages over the past five years. This narrative review aims on what is already known regarding application of aptamer technology in enterobacteria and non-fermenters, and the prospects for future achievements. A systematic search of the English literature was performed on the 7th of December 2021 to identify papers on aptamer discovery, with a focus on gram negative isolates, published from January 01, 1993, to December 07, 2021, under the topics: (aptamer OR aptamers OR SELEX) AND (bacteria OR sepsis OR non-fermenter OR Enterobacteriaceae OR infection)). The reference lists of included articles were also searched, in addition to hand-searching of various relevant high-impact journals. Out of 2,474 articles, 30 experimental studies were recruited for review, and are chronologically described. Although the number of publications regarding development of aptamers to target these pathogenic agents has increased over the years, the recent publications are mostly around diagnostic devices manufactured using previously described aptamers. There have been less than one-third of the studies describing new and specific aptamers. From the 30 selected papers, 18 are regarding non-fermenters, seven approaching multi-species of bacteria and only five regarding a single enterobacteria. Even for the newly described aptamers, most of the published papers pertain to diagnostic aptamers and only seven focus on aptamers for therapeutics. The number of aptamers with strong and specific binding capacity are still limited. Improving the current SELEX and developing more APT remains the major hurdle for aptamer related studies.

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“…Ciprofloxacin (CPX) and single-walled carbon nanotubes (SWNTs) are the most common nanomaterials with a strong antibiofilm activity. Combination of aptamer-CPX-SWNTs showed the potential of drug delivery and biofilm formation overmaster [ 80 ].…”

Section: Applications Of Fnas For Infectious Diseasesmentioning

confidence: 99%

“…P. aeruginosa aptamer inhibited bacterial infections by targeting biofilm. Therefore, the P. aeruginosa aptamer can be used in biofilm treatment [80]. Ciprofloxacin (CPX) and single-walled carbon nanotubes (SWNTs) are the most common nanomaterials with a strong antibiofilm activity.…”

Section: Therapy For Bacterial-induced Diseasesmentioning

confidence: 99%

Selection and applications of functional nucleic acids for infectious disease detection and prevention

et al. 2021

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Infectious diseases caused by pathogenic microorganisms such as viruses and bacteria pose a great threat to human health. Although a significant progress has been obtained in the diagnosis and prevention of infectious diseases, it still remains challenging to develop rapid and cost-effective detection approaches and overcome the side effects of therapeutic agents and pathogen resistance. Functional nucleic acids (FNAs), especially the most widely used aptamers and DNAzymes, hold the advantages of high stability and flexible design, which make them ideal molecular recognition tools for bacteria and viruses, as well as potential therapeutic drugs for infectious diseases. This review summarizes important advances in the selection and detection of bacterial-and virus-associated FNAs, along with their potential prevention ability of infectious disease in recent years. Finally, the challenges and future development directions are concluded.

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Influence of aptamer-targeted antibiofilm agents for treatment of Pseudomonas aeruginosa biofilms

Cited by 36 publications

References 28 publications

Therapeutic applications of nucleic acid aptamers in microbial infections

Therapeutic applications of nucleic acid aptamers in microbial infections

Application of aptamer technology in enterobacteria and non-fermenters: literature review

Selection and applications of functional nucleic acids for infectious disease detection and prevention

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