Influence of CuO/MgO ratio on the gene expression, cytocompatibilty, and antibacterial/anticancerous/analgesic drug loading kinetics for (15‐x) CuO‐xMgO‐10P2O5‐60SiO2‐10CaO‐5ZnO (2.5 ≤ x ≤ 12.5) mesoporous bioactive glasses

Bains, Rupinderjeet; Sharma, Piyush; Mir, Rameez Ahmad; Jeet, Suninder; Kaur, Gurbinder; Pandey, O.P.

doi:10.1002/jbm.a.36415

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…77,83,85 Also, even the type of ions can affect drug-loading concentrations. For example, doping with Cu and Se 106,107 was shown to be associated with drug-loading increase, but Mg, Zn 106,108 reduced the drug-loading concentration in MBGs structure. The effect on drug-loading capability is related to morphological changes in terms of pore volume, surface area, and pore size of MBGs.…”

Section: Drug and Ion Deliverymentioning

confidence: 99%

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini

Chinijani

Khachatourian

et al. 2022

Int J of Appl Glass Sci

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There is an ongoing profound shift in using glass as a primarily passive material to one that instills active properties. We believe and demonstrate that bioactive glasses (BGs) and glass–ceramics (BGCs) as functional biomaterials for cancer therapy can transform the world of healthcare in the 21st century. Melt/gel‐derived BGs and BGCs can carry many exotic elements, including less common rare‐earth, and trigger highly efficient anticancer properties via the combination of radiotherapy, photothermal therapy, magnetic hyperthermia, along with drug or therapeutic ions delivery. The addition of these dopants modifies the bioactivity, imparts novel functionalities, and induces specific biological effects that are not achievable using other classes of biomaterials. In this paper, we have briefly reviewed and discussed the current knowledge on promising compositions, processing parameters, and applications of BGs and BGCs in treating cancer. We also envisage the need for further research on this particular, unique class of BGs and BGCs.

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Section: Drug and Ion Deliverymentioning

confidence: 99%

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Moeini

Chinijani

Khachatourian

et al. 2022

Int J of Appl Glass Sci

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“…Higher loading concentrations usually lead to enhanced drug loading capacity; [122,123] By contrast, some studies indicated that DOX loading capacity of MBGs decreased when the loading concentration increased. [113,114] The drug loading amount depends on the pore size and surface area of MBGs. [110,120,121] The effect of therapeutic ions incorporated in MBGs on the loading capacity has been investigated.…”

Section: Chemotherapeutic Drug Deliverymentioning

confidence: 99%

“…[112,114,123] On the other hand, it has been concluded that higher amounts of folic acid, Mg, and Zn decrease the loading capacity of MBGs. [113,114,41] Hence, an optimized drug loading content and efficiency can be obtained by tuning the chemical composition of the MBG carrier and tailoring structural characteristics.…”

Section: Chemotherapeutic Drug Deliverymentioning

confidence: 99%

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

et al. 2021

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Cancer is one of the top life‐threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy‐to‐functionalize nature and tailorable textural properties—surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli‐responsive nanoplatforms), and immunological profile of MBG‐based nanodevices in reference to the development of novel cancer therapeutics.

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“…The first one deals with tuning the host-guest MBGs-drugs interactions to achieve higher control over drug loading and release kinetics and the incorporation of stimuli-responsive elements to allow on-demand cargo release. Among antitumor drugs, the most frequently loaded has been doxorubicin (DOX) [207][208][209][210][211], scarcely imatinib [212], curcumine [213] and daunomycin [214].…”

Section: Antitumor Drugsmentioning

confidence: 99%

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

et al. 2022

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Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for local drug delivery. Since their discovery at the beginning of the 21st century, pioneering research efforts focused on the design and fabrication of MBGs with optimal compositional, textural and structural properties to elicit superior bioactive behavior. The current trends conceive MBGs as multitherapy systems for the treatment of bone-related pathologies, emphasizing the need of fine-tuning surface functionalization. Herein, we focus on the recent developments in MBGs for biomedical applications. First, the role of MBGs in the design and fabrication of three-dimensional scaffolds that fulfil the highly demanding requirements for bone tissue engineering is outlined. The different approaches for developing multifunctional MBGs are overviewed, including the incorporation of therapeutic ions in the glass composition and the surface functionalization with zwitterionic moieties to prevent bacterial adhesion. The bourgeoning scientific literature on MBGs as local delivery systems of diverse therapeutic cargoes (osteogenic/antiosteoporotic, angiogenic, antibacterial, anti-inflammatory and antitumor agents) is addressed. Finally, the current challenges and future directions for the clinical translation of MBGs are discussed.

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Influence of CuO/MgO ratio on the gene expression, cytocompatibilty, and antibacterial/anticancerous/analgesic drug loading kinetics for (15‐x) CuO‐xMgO‐10P₂O₅‐60SiO₂‐10CaO‐5ZnO (2.5 ≤ x ≤ 12.5) mesoporous bioactive glasses

Cited by 8 publications

References 48 publications

A critical review of bioactive glasses and glass–ceramics in cancer therapy

A critical review of bioactive glasses and glass–ceramics in cancer therapy

Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Achievements in Mesoporous Bioactive Glasses for Biomedical Applications

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