Influence of D-asparagine on the proliferative activity of human dermal fibroblasts

Sergeeva, Yulia Anatolievna; Trofimenko, A. I.; Fedorenko, T V; Гилевич, И. В.; Kolomiytseva, Elena Anatolievna; Каде, А. Х.

doi:10.14300/mnnc.2020.15085

Cited by 1 publication

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References 5 publications

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“…This trend may be due to a degree of slowdown in the proliferative activity of cells under the influence of D-asparagine during the initial period after scaffold implantation. This hypothesis is supported by the fact that in vitro D-asparagine reduced the proliferative activity of dermal fibroblasts during a 48-hour incubation [6].…”

Section: ключевые слова: D-аспарагин биополимерный скаффолд кожа ожог фрактальный анализmentioning

confidence: 80%

Influence of D-asparagine on the engraftment of a biopolymer scaffold for replacing skin defects

Kade¹,

Trofimenko²,

Богданов³

et al. 2021

Medical news of the North Caucasus

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Оригинальные исследОванияЭкспериментальная медицина E arly necrectomy with skin autograft primary autoplasty is the method of choice in the treatment of burn injury patients [1, 2]. However, questions remain regarding the quality of skin healing, the formation of dermal scars, and the lack of donor material in patients with extensive grade III burns [1,3]. In this regard, the development of biodegradable hydrogel scaffolds (based on biopolymers of natural origin, such as sodium alginate and gelatin) capable of performing the role of wound coating and regenerative matrix is an actual and promising approach in solving of these problems [4, 5].Under experimental conditions, there is significant potential for influencing the dynamics of cellular reactions, the nature of colonization, and remodeling of the scaffold after its implantation by using modulators of the proliferative activity of dermal matrix cells, including those based on a natural metabolite such as D-asparagine [6-8], which expands the possibilities for studying it in burn injury models.The aim of the study was to determine the effect of D-asparagine on the engraftment of a biopolymer scaffold in the replacement of skin defects after burn wounds necrectomy in rats.Material and Methods. Twenty inbred male Wistar rats weighing 270-300 g were used in this study. All interventions capable of causing pain or suffering to animals were performed under anesthesia using 20 mg/ kg tiletamine hydrochloride (Zoetis Inc., USA) and 6 mg/ kg xylazine hydrochloride (NITA-PHARM, Russia), both applied intramuscularly. When performing traumatic manipulations with an antimicrobial purpose, animals were injected with 2.5 mg/kg gentamicin sulfate (Agrofarm, Russia) intramuscularly.

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Section: ключевые слова: D-аспарагин биополимерный скаффолд кожа ожог фрактальный анализmentioning

confidence: 80%

Influence of D-asparagine on the engraftment of a biopolymer scaffold for replacing skin defects

Kade¹,

Trofimenko²,

Богданов³

et al. 2021

Medical news of the North Caucasus

Self Cite

View full text Add to dashboard Cite

show abstract

Influence of D-asparagine on the proliferative activity of human dermal fibroblasts

Cited by 1 publication

References 5 publications

Influence of D-asparagine on the engraftment of a biopolymer scaffold for replacing skin defects

Influence of D-asparagine on the engraftment of a biopolymer scaffold for replacing skin defects

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