Influence of hyper‐harmonized fullerene water complex on collagen quality and skin function

Abstract

Background: Fullerene water complex establishes the optimal order and function of biomolecules in natural, biophysical way by transducing the signal through water hydrogen bonds to biomolecules.Objectives: This paper considers the effects of the patented hyper-harmonized-hydroxylated fullerene water complex (3HFWC) on biophysical properties of the skin collagen molecules.Method: Optomagnetic imaging spectroscopy (OMIS) has been used for the analysis of the biophysical skin properties (diamagnetic/paramagnetic) after applying three groups of different cosmetic products. Tested cosmetic products were prepared by replacing the active ingredients with 3HFWC or with water in four commercial products. The original commercial creams and their vehiculums with water added served as control groups. Data were statistically analyzed using paired t test in R software.Results: t Test gave statistically significant results for all of the products with 3HFWC, while within the control group, only body lotion and hand cream did show statistically significant results (P < 0.05). Significant improvements in abundance and quality of collagen in the dermis were achieved with body lotion with 3HFWC (p + /p − ranged from 0.82 to 0.97). While body lotion vehiculum made collagen-water interaction more stable (p + /p − ranged from 0.3 to 0.55), hand cream with 3HFWC made it more dynamic (p + /p − ranged from 0.63 to 0.49). Body lotion vehiculum improved the compactness of the dermis (p + /p − ranged from 0.2 to 1.03), as well as commercial hand cream (p + /p − ranged from 0.28 to 0.85). Conclusion:Compared to the control groups, cosmetic products with 3HFWC demonstrated positive effects on the biophysical properties of the skin. Increased paramagnetic properties are linked to more unpaired electrons, their faster movement, and, finally, better signal transduction. Thus, products with 3HFWC could enable faster regeneration of collagen and prompt skin reaction to the negative environmental influences.

Physiological Response, Oxidative Stress Assessment and Aquaporin Genes Expression of Cherry Tomato (Solanum lycopersicum L.) Exposed to Hyper-Harmonized Fullerene Water Complex

“…Plantlets exposed to 3HFWC nanosubstance successfully grown during the whole vegetative growth, flowered, and produced fruits. It is evident that the structure of 3HFWC nanosubstance, whose diameter size ranges between 8–12 nm had no toxicity effects on cherry tomato as it has already shown for human cells [ 13 , 48 ]. The bio-distribution of 3HFWC nanosubstance in cherry tomato plants can be visualized as numerous black aggregates (deposits) in bleached plant tissues (xylem and leaves) after prolonged exposure.…”

“…Hydroxylated fullerene (fullerols) showed strong free radical scavenging against reactive oxygen species (ROS) and antioxidative activity, demonstrating their multipotent biological usage [ 10 , 11 ]. Functionalized forms of fullerene have been recognized as powerful antioxidants with applications in chemotherapy, dermatology, neurodegenerative diseases and radiobiology that are very well established [ 12 , 13 , 14 ].…”

“…The entire nanosubstance is 6–18 nm in size and has no toxicity effects in the tests on human dermal fibroblasts and liver carcinoma cells [ 8 , 48 ]. It has a commercial application in cosmetics as an active component ingredient “hydroxylated fullerene” [ 13 ], and it has been shown to promote melanoma cell reprogramming toward a normal phenotype [ 49 ].…”

Mechanisms of skin moisturization with hyperharmonized hydroxyl modified fullerene substance

“…Optomagnetic Imaging Spectroscopy is a method for the analysis of light‐matter interaction based on spectral convolution 18 . OMIS enables collection and analysis of dermal images using a noninvasive imaging device, which includes a set of light emitting diodes serving as electromagnetic radiation source, and detector for measuring re‐emitted radiation from the location on the skin 6,13,19 . This method determines a moisture level based on the ratio of incident and reflected light, by capturing an image of skin illuminated with incident white diffuse light (W), blue light (B), and angled light.…”

Desain Primer Gen 12S sRNA dari DNA Mitrokondria Babi (Sus scrofa) secara In Silico sebagai Kandidat Primer dalam Analisis Molekuler Kehalalan Produk

“…Salah satu produk kosmetika yang banyak mengandung turunan babi adalah kolagen [4]. Kolagen dapat ditambahkan pada produk kosmetika baik dalam bentuk krim kolagen ataupun lotion untuk mencegah terjadinya penuaan dini [5][6][7]. Kolagen merupakan protein yang dapat diperoleh dari jaringan ikat atau daging mamalia [8].…”