Influence of insulin treatment and feed restriction on follicular development in cyclic gilts

Quesnel, Hélène; Pasquier, A.; Jan, N; Prunier, Armelle

doi:10.1016/s0378-4320(00)00195-0

Cited by 12 publications

(8 citation statements)

References 26 publications

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“…Possibly, there could be a metabolic aspect of this phenomenon in the relatively fatter breed of Mangalica. Unfortunately, no metabolic hormones were determined in the peripheral blood or FF in the present study to elucidate the link between metabolic and reproductive hormones (Quesnel et al. 2000; Almeida et al.…”

Section: Discussionmentioning

confidence: 99%

Superovulatory Ovarian Response in Mangalica Gilts is Not Influenced by Feeding Level

Egerszegi

Hazeleger

Rátky

et al. 2007

Reprod Domestic Animals

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The aim of the study was to compare how different feeding levels affect the ovarian potential of follicular development and oocyte maturation in response to superovulatory treatment in native Mangalica (M, n = 17) compared with Landrace (L, n = 20) pigs. Gilts of both breeds were fed high-energy (HI-2.5 kg) or low-energy (LO - 1.25 kg) feed during oestrus synchronization (15 days of Regumate feeding) till the time of oocyte aspiration (Day 6 after Regumate). Follicular growth was stimulated by the administration of 1000 IU equiue choriou gonadotropiu (eCG) 24 h after Regumate treatment, and ovulation was induced by injection of 750 IU human choriou gonadotropiu (hCG) 80 h after eCG administration. Ultrasound (US) investigation was done three times (4-10 h before, and 40-44 and 72-74 h after eCG administration) for the observation of follicular development. Oocyte and follicular fluid (FF) were collected endoscopically 34 h after hCG injection. Cumulus-oocyte complexes were evaluated, their morphology determined, and thereafter fixed and stained for chromatin evaluation. Oocytes were classified as meiosis-resumed (germinal vesicle breakdown, diakinesis, metaphase I to anaphase I) or matured (telophase I and metaphase II). FF concentrations of oestradiol and progesterone were measured by validated radioimmunoassays. In L gilts, differences were observed between HI and LO in the number of preovulatory follicles (32.3 +/- 10.5 vs 17.1 +/- 12.3, p < 0.05), but not in M (25.3 +/- 2.9 vs 28.8 +/- 7.3, p > 0.05). Initial follicular growth was not affected by feeding levels; however, preovulatory follicle size was larger in M (7.1 +/- 0.9 and 6.9 +/- 1.1 mm vs 5.7 +/- 0.7 and 5.5 +/- 0.8 mm; p < 0.05). No differences were obtained with relation to mature chromatin configuration in both breeds (L gilts: HI - 70% and LO-67% vs M gilts: HI - 67% and LO - 63%). A twofold higher oestradiol concentration was detected in FF of HI-M and LO-M (29.6 +/- 6.8 and 30.9 +/- 10.3 ng/ml respectively) compared with that of L (16.9 +/- 9.7 and 17.9 +/- 3.6 ng/ml, respectively; p < 0.05). The mean FF progesterone level was nearly fivefold higher in M (2020.4 +/- 1056 and 1512.2 +/- 1121.8 ng/ml) compared with L (386.2 +/- 113.7 and 298.8 +/- 125.9 ng/ml, p < 0.05). The results indicate an influence of the feeding of altered energy on the number of recruitable preovulatory follicles in modern Landrace but not in native Mangalica breed. Moreover, the follicular steroid hormone milieu differs between Landrace and Mangalica gilts but not depending on feeding levels. Oocyte maturation was not affected by diet.

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Section: Discussionmentioning

confidence: 99%

Superovulatory Ovarian Response in Mangalica Gilts is Not Influenced by Feeding Level

Egerszegi

Hazeleger

Rátky

et al. 2007

Reprod Domestic Animals

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“…There is general agreement that metabolic intermediates such as glucose, insulin and IGF‐I affect the reproductive axis both through their effects on gonadotrophic secretion and through their direct effects on ovarian physiology, although these effects may be independent (Quesnel et al. ; Lucy et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…Quesnel et al. (), for example, showed that in a gilt model, feed restriction in the pre‐follicular (luteal) phase does not necessarily reduce LH secretion but does affect ovarian follicular development. In the same model, these authors showed that suppression of LH with a GnRH antagonist does also affect follicle development, stressing the importance of the gonadotrophic axis and potential effects of a metabolic challenge.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pre‐Weaning Energy Substitutions on Post‐Weaning Follicle Development, Steroid Hormones and Subsequent Litter Size in Primiparous Sows

Chen

Stott

Bouwman

et al. 2012

Reprod Domestic Animals

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The present study investigated the effects of pre-weaning energy substitutions on follicular development, endocrine characteristics and subsequent litter size in primiparous sows. Sows were fed a standard lactation diet (14.1 DE MJ/kg) and then allocated to a Control (C, n = 24), Fat (F, n = 23), Sugar (S, n = 23) or post-weaning Regumate (positive control; R, n = 22) treatment at 9 days before weaning of the C, F and S treatments. During the treatment period (8 days), 1 kg of the lactation diet was substituted with 1 kg of a fat-rich (F, 23.85 DE MJ/kg) or sugar-rich (S, 15.75 DE MJ/kg) substitution for F and S sows, respectively. For the R treatment, sows were weaned 8 days earlier than other treatments and fed a lactation diet at 3.5 kg with two doses of altrenogest as topdressing from 1 day before weaning until the day on which the other sows were weaned. The F treatment aimed to increase energy intake, and the S treatment aimed to elevate post-prandial glucose and insulin concentrations. Weaning-to-ovulation interval tended to be reduced in the S treatment compared with C (p = 0.06) and F (p = 0.08) treatments. Body weight (BW) loss during the treatment period, post-weaning follicle development, plasma oestradiol and pre-weaning leptin did not differ among C, F and S sows, although BW loss was lower and leptin was higher in the R treatment. Post-ovulatory progesterone concentration in the S treatment was higher (p < 0.05). Sows in the S and R treatments had a greater proportion of litters with larger litter sizes (p < 0.05). The outcome suggests that increasing circulating insulin and glucose concentrations during late lactation or a week of metabolic recovery positively improves subsequent litter size in primiparous sows.

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“…T h e p r e s e n t s t u d y demonstrated that the maturation rate of porcine oocytes cultured in modified NCSU 37 medium, which included 5.6 mM glucose, at low oxygen tension was the same as that cultured at high oxygen tension. The most feasible reason for the discrepancy is that the medium used for in vitro maturation of oocytes in the present study includes 10% porcine follicular fluid, which contains a higher concentration of glucose than does the plasm [27], but others included 10% bovine calf serum [7] or no supplementation [3]. The developmental potential of parthenogenetic oocytes to blastocysts was also not different among groups.…”

Section: Discussionmentioning

confidence: 75%

Effect of Oxygen Tension on the Developmental Potential of Parthenogenetic Oocytes and Nuclear-Transferred Porcine Oocytes Receiving Fetal Fibroblast Cells.

Kawakami

Tani

Yin

et al. 2002

Journal of Reproduction and Development

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Abstract. The effects of oxygen tension (5% and 20%) during in vitro culture of oocytes and fetal fibroblast cells on the developmental potential of parthenogenetic and nuclear-transferred porcine oocytes were examined. The potential of parthenogenetic oocytes matured and cultured under different oxygen tensions to develop into blastocysts was not significantly different (5 to 16%). The proportions of enucleated oocytes receiving fetal fibroblast cells that developed into blastocysts were significantly lower when somatic cells were cultured under low oxygen tension (2 and 3%) than under high oxygen tension (7%). The effects of oxygen tension during culture of oocytes and somatic cells on the developmental potential of parthenogenetic and nuclear-transferred oocytes is discussed.

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Influence of insulin treatment and feed restriction on follicular development in cyclic gilts

Cited by 12 publications

References 26 publications

Superovulatory Ovarian Response in Mangalica Gilts is Not Influenced by Feeding Level

Superovulatory Ovarian Response in Mangalica Gilts is Not Influenced by Feeding Level

Effects of Pre‐Weaning Energy Substitutions on Post‐Weaning Follicle Development, Steroid Hormones and Subsequent Litter Size in Primiparous Sows

Effect of Oxygen Tension on the Developmental Potential of Parthenogenetic Oocytes and Nuclear-Transferred Porcine Oocytes Receiving Fetal Fibroblast Cells.

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