Influence of Laser (λ670 nm) and Dexamethasone on the Chronology of Cutaneous Repair

Abstract

Laser was effective in reducing swelling and polymorphonuclear cells and accelerated tissue repair, even in the presence of dexamethasone.

Ultrastructure and Light Microscope Analysis of Intact Skin after a Varying Number of Low Level Laser Irradiations in Mice

“…Despite the increase in density of collagen fibers observed in the group of three laser applications, the difference was not significant compared to the control group of six and 10 and the irradiated group that received six applications, suggesting no formation of new collagen fibers in the intact skin. However, laser action in the treatment of tendons [28] and on skin wound healing therapy increased collagen fibers [5, 8, 17, 29, 30]. The difference between these results and those of our study may be explained by irradiation having been applied on intact skin of our animals, which have no need of a major renovation of collagen.…”

“…Dermatological researches have also reported experimental improvements associated with LLLT for facial rejuvenation treatment [4] and cutaneous wound healing [5]. However, as presented in the literature, different laser types, energy density, duration of treatment, and other parameters were used in the studies.…”

“…However, as presented in the literature, different laser types, energy density, duration of treatment, and other parameters were used in the studies. Some researches show a faster skin repair, such as using the National Aeronautics and Space Administration (NASA) light-emitting diode (LED) 880 nm, delivering 4 J/cm 2 and 50 mW/cm 2 for 14 consecutive days [6]; the aluminum-gallium-indium-phosphorus (AlGaInP) diode laser 670 nm, 25 mW/cm 2 , irradiating the total daily energy density of 30 J/cm 2 [7]; the helium-neon (He-Ne) laser, 632.8 nm, 10 mW, energy density of 1 J/cm 2 irradiated on the 1st, 5th, 8th, 12th, and 15th day after-wounding [8]; the VR-KC-610 Laser, Dentoflex, CW, Brazil, l670 nm, 9 mW, 0.031 W/cm 2 , 4 J/cm 2 , single irradiation after surgery [5]; and the NAFL and AFL treatments which were performed with the same total energy of 12,000 mJ cm 2 , with four sessions and an interval of 3 weeks between sessions. So with all the variability used in these studies, it is difficult to compare different results.…”

Chitosan Imparts Better Biological Properties for Poly(ε-caprolactone) Electrospun Membranes than Dexamethasone

“…Dexamethasone is a well-known drug due to its capacity to stimulate proliferation of mesenchymal stem cells, 30 and because of its anti-inflammatory properties. 7 Dexamethasone has been used to treat cancer, 42 skin diseases, 43 acute bacterial meningitis, 44 and other diseases. Also, dexamethasone can be used for local anesthetic pain relief therapy; 45 however, skin atrophy is accelerated by topical dexamethasone treatments, which is widely used in dermatology.…”

The effects of low level laser therapy on injured skeletal muscle

“…Some physical agents have been used to treat the skeletal muscle conditions, including low-laser therapy (LLLT) (Mesquita-Ferrari et al 2011;Baptista et al 2011). This therapy is effective in reducing post-injury inflammatory processes, stimulating the formation of new blood vessels and accelerating soft tissue healing (Chung et al 2010;Marchionni et al 2011). Some studies have demonstrated that LLLT has stimulatory effects on muscle cells and skeletal muscle regeneration after an injury (Amaral et al 2001;Baptista et al 2011).…”