Influence of non‐steroidal anti‐inflammatory drugs (<scp>NSAID</scp>s) on osseointegration of dental implants in rabbit calvaria

Cai, Wei; Ma, Li; Zheng, Li Wu; Kruse-Gujer, Astrid L.; Stübinger, Stefan; Lang, Niklaus P.; Zwahlen, Roger A.

doi:10.1111/clr.12392

Cited by 24 publications

(22 citation statements)

References 41 publications

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“…One clinical study was classified as unclear risk of bias (for one or more domain) according to the Cochrane Collaboration’s Tool [ 17 , 21 ]. An in vivo animal study had an unclear risk of bias according to the ARRIVE guidelines [ 18 , 22 ].…”

Section: Reviewmentioning

confidence: 99%

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

et al. 2018

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Non-steroidal anti-inflammatory drugs are commonly used in implant dentistry for management of post-operative pain. The objective of this systematic review was to analyse the effect of non-steroidal anti-inflammatory drugs on the osteogenic activity of osteoblasts with an emphasis on its effect on osseointegration. A systematic literature search for in vitro, animal models, and clinical trials was conducted using Ovid, PubMed, Scopus, and Web of Science databases. Articles published since the introduction of selective COX-2 inhibitors, between January 1999 and July 2018, were selected. The integrated search followed the PRISMA statement with the following key terms: non-steroidal anti-inflammatory drug/s, titanium, osseointegration, and osteoblast. The review is registered at PROSPERO database: CRD42016051448. The titles and abstracts of each research article in the initial search (n = 875) were independently screened by two reviewers. A third independent reviewer reviewed the articles that were included by one but excluded by the other reviewer. This resulted in the cataloguing of 79 full-text manuscripts where the articles were assessed for the following criteria: the study investigates the effects of NSAIDs on osteoblasts, explores the COX pathway and its effect on osteogenic activity, and compares the effects of NSAIDs on osteoblasts with a control group. A total of 13 articles have been included for qualitative synthesis. There is a lack of consensus in the literature to explicitly conclude that there is a relationship between the use of post-operative NSAIDs and failed osseointegration; however, osseointegration does not appear to be negatively affected by NSAIDs in the human clinical studies.

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Section: Reviewmentioning

confidence: 99%

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

et al. 2018

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“…Studies have sought to observe if the different balance of COX-1 / COX-2inhibition in highly selective NSAIDs would interfere less or not at all on bone healing and tooth movement. Some authors point out the Coxibs as a source of disorder in orthodontic treatment capable of interfering in the tooth movement process [11], while others have not seen such effect [12,13].…”

Section: Coxibs In Dentistry: An Updatementioning

confidence: 99%

Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos

Souza

Caldas

Silva

2016

Rev. Odonto Ciênc. (Online)

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The coxibs are nonsteroidal anti-inflammatory drugs (NSAIDs) highly selective for COX-2, an enzyme related to inflammatory processes. At first, their use should present advantages over nonselective NSAIDs, since the inflammatory efficacy would be present but with minimal adverse effects. However, its widespread use showed significant cardiovascular risk and, in treatment over 6 months, predisposition to ulceration, bleeding and stomach pain. The coxibs should be used in patients over 60 years, with a history of peptic ulcer or gastrointestinal bleeding, chronic users of corticosteroids and anticoagulants without concomitant cardiovascular risk. Moreover, they are more expensive and have similar analgesic efficacy to non-selective NSAIDs. In dentistry, the main indications are related to the control of pain and inflammation for a maximum of 3 days or preemptively in oral surgery to control pain and swelling. However, there is no major evidence of the benefits of using these drugs compared to traditional NSAIDs in dentistry.Key words: Dentistry; Anti-Inflammatory agents; Cyclooxygenase 2 inhibitors; Adverse effects; Therapeutic use; Contraindications Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos ResumoOs coxibes são antiinflamatórios não-esteroidais (AINEs) altamente seletivos para a COX-2, enzima relacionada à processos inflamatórios. A princípio, seu uso deveria apresentar vantagens em relação aos não-seletivos, pois permaneceria a eficácia antiinflamatória com um mínimo de efeitos adversos. Entretanto, sua ampla utilização revelou significativo risco cardiovascular e, em tratamento acima de 6 meses, predisposição à ulcerações, hemorragias e dor gástricas. Sendo recomendado seu uso em pacientes acima de 60 anos, com histórico de úlcera gástrica ou hemorragia digestiva, usuários crônicos de corticosteóides e anticoagulantes. Além disto, são mais caros e possuem eficácia analgésica similar aos AINEs não-seletivos. Em odontologia suas principais indicações estão relacionadas ao controle da dor e da inflamação pelo período máximo de 3 dias ou preemptivamente em cirurgias orais para controle da dor e edema. Entretanto, não há evidências de maiores benefícios da utilização destes fármacos em relação aos AINES tradicionais no manejo odontológico.

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“…14,15 Recently, Cai et al show that postoperatively 7-day regimen of appropriate doses, selective and nonselective NSAID's dose, not adversely effect osseointegration. 16 This study investigated the effect of NSAID use on osseointegration in a rabbit model using both HA-and grit-blasted titanium implants. The quality of osseointegration is investigated quantitatively, using biomechanical and histologic parameters.…”

Section: Introductionmentioning

confidence: 99%

Effects of NSAIDs and hydroxyapatite coating on osseointegration

Salduz

Dikici

Kılıçoğlu

et al. 2017

J Orthop Surg (Hong Kong)

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Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and gritblasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically. Results: HA-coated implants had a significantly better failure load and ''percentage of bone-implant contact'' than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations. Conclusions: Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with gritblasted implants.

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Influence of non‐steroidal anti‐inflammatory drugs (NSAIDs) on osseointegration of dental implants in rabbit calvaria

Abstract: In rabbits, a 7-day regimen of appropriate doses of diclofenac sodium and parecoxib did not adversely affect osseointegration of dental implants and bone healing in calvaria, neither short nor long term (12 weeks).

Cited by 24 publications

References 41 publications

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review

Inibidores seletivos da cox-2 na odontologia: limitações e efeitos adversos

Effects of NSAIDs and hydroxyapatite coating on osseointegration

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