Influence of poly(ε-caprolactone) end-groups on the temperature-induced macroscopic gelation of Pluronic in aqueous media

Gjerde, Natalie; Zhu, Kaizheng; Knudsen, Kenneth Dahl; Nyström, Bo

doi:10.1016/j.eurpolymj.2019.01.033

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…Thus, the hydrophobicity increased with CL content in the substrates. 27,39 The radial and circumferential layer PCL/PLCL substrates had contact angles of 93.22 ± 0.25 and 114.55 ± 0.33°, respectively (Figure 3d,e). Increasing the PLCL content in the PCL/PLCL polymer blend reduced the hydrophobicity of the substrates due to the higher LA content.…”

Section: Resultsmentioning

confidence: 99%

Elastomeric Trilayer Substrates with Native-like Mechanical Properties for Heart Valve Leaflet Tissue Engineering

Snyder

Jana

2023

ACS Biomater. Sci. Eng.

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Heart valve leaflets have a complex trilayered structure with layer-specific orientations, anisotropic tensile properties, and elastomeric characteristics that are difficult to mimic collectively. Previously, trilayer leaflet substrates intended for heart valve tissue engineering were developed with nonelastomeric biomaterials that cannot deliver native-like mechanical properties. In this study, by electrospinning polycaprolactone (PCL) polymer and poly(l-lactide-co-ε-caprolactone) (PLCL) copolymer, we created elastomeric trilayer PCL/PLCL leaflet substrates with native-like tensile, flexural, and anisotropic properties and compared them with trilayer PCL leaflet substrates (as control) to find their effectiveness in heart valve leaflet tissue engineering. These substrates were seeded with porcine valvular interstitial cells (PVICs) and cultured for 1 month in static conditions to produce cell-cultured constructs. The PCL/PLCL substrates had lower crystallinity and hydrophobicity but higher anisotropy and flexibility than PCL leaflet substrates. These attributes contributed to more significant cell proliferation, infiltration, extracellular matrix production, and superior gene expression in the PCL/PLCL cell-cultured constructs than in the PCL cell-cultured constructs. Further, the PCL/PLCL constructs showed better resistance to calcification than PCL constructs. Trilayer PCL/PLCL leaflet substrates with native-like mechanical and flexural properties could significantly improve heart valve tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Elastomeric Trilayer Substrates with Native-like Mechanical Properties for Heart Valve Leaflet Tissue Engineering

Snyder

Jana

2023

ACS Biomater. Sci. Eng.

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“…Montmorillonite (Kunipia-F) was dispersed (4 g) in 100 mL of water. 16 And 1.06 mL of C 10 E 5 nonionic surfactant was added to the solution and stirred overnight. The obtained dispersion was centrifuged twice at 5500 rpm and dried at 80 °C for 48 h. Water was added to rinse the solid organoclay (OMMT), which was dispersed again in water to prepare the dispersions of organo-montmorillonite (OMMT) nanosheets at concentrations of 1, 2, 5, 10 g L −1 .…”

Section: Methodsmentioning

confidence: 99%

“…Other mechanisms were proposed for the gel formation implying the release of water bound to the PO groups with the increase of the temperature, leading to a gain of the entropy that induces the endothermic transition. 9,12,16,17 However, the nal properties of the hydrogels mainly depend on their mechanical properties that represent a central issue regarding their high-water content. One possibility consists of the functionalization of the polymers with methacrylate groups for an improvement of the cross-linking or by the inclusion of inorganic particles that can form a cross-linked network as well as exemplary in the case of graphene oxide sheets in sodium alginate hydrogel nanocomposite.…”

Section: Introductionmentioning

confidence: 99%