Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic or Conventional Cholecystectomy

Mijatović, Sanja; Alempijević, Tamara; Stefanović, B; Jeremić, Vasilije; Krstić, S; Radmanović, Nikola; Jovanović, Sanja; Stefanović, Branislav

doi:10.1515/jomb-2017-0004

Cited by 4 publications

(7 citation statements)

References 16 publications

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“…However, IL-6 growth during open cholecystectomy was greater compared to laparoscopic cholecystectomy (62.51-fold vs. 3.19-fold). Our results are in line with other studies indicating increased inflammatory response in open surgery in comparison to the equivalent laparoscopic one [ 19 – 22 , 36 , 37 ].…”

Section: Discussionsupporting

confidence: 93%

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Intraoperative Peritoneal Interleukin-6 Concentration Changes in Relation to the High-Mobility Group Protein B1 and Heat Shock Protein 70 Levels in Children Undergoing Cholecystectomy

Tylicka

Matuszczak

Kamińska

et al. 2020

Mediators of Inflammation

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The aim was the evaluation of IL-6 concentration in peritoneal lavage fluid of children which underwent cholecystectomy to ascertain if there is a difference in early inflammatory response depending on the type of surgical approach (open vs. laparoscopy). The analysis of high-mobility group protein B1 (HMGB1) and heat shock protein 70 (HSP70) was performed to find out if the source of IL-6 was related to tissue damage. IL-6 concentration in peritoneal lavage fluid samples, obtained at the beginning and at the end of the laparoscopic (N=23) and open cholecystectomy (N=14), was tested with a routinely used electrochemiluminescence assay. The concentrations of HMGB1 and HSP70 were analyzed with the use of an ELISA method. Statistical analysis was performed using the STATISTICA PL release 12.5 Program. The differences were assessed using the Mann-Whitney U test and Wilcoxon matched pairs test. Correlations were studied by using the Spearman correlation test. Our results demonstrated significant peritoneal lavage fluid IL-6 concentration growth measured at the end of the cholecystectomy as compared to the beginning, regardless of the type of the procedure. IL-6 growth during open cholecystectomy was greater compared to laparoscopic cholecystectomy (62.51-fold vs. 3.19-fold). IL-6 concentration did not correlate with HMGB1 and HSP70, which indicate that the significant growth of this cytokine was not related to mechanical tissue damage due to surgical procedure. A clinical significance of the study could be related to the fact that the evaluation of IL-6 concentration in peritoneal lavage fluid may be useful to assess an early local inflammatory response.

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Section: Discussionsupporting

confidence: 93%

“…Numerous studies show that levels of circulating plasma proinflammatory cytokines, including IL-6, are related to the extent and severity of surgical procedure [ 18 – 22 ]. IL-6 concentration was mostly measured in plasma or serum [ 18 – 20 ]; rarely, it was assessed in peritoneum [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Peritoneal Interleukin-6 Concentration Changes in Relation to the High-Mobility Group Protein B1 and Heat Shock Protein 70 Levels in Children Undergoing Cholecystectomy

Tylicka

Matuszczak

Kamińska

et al. 2020

Mediators of Inflammation

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“…White blood cells subtypes follow various inflammatory reactions of the body. Recently, neutrophilia and relative lymphopenia were proposed as predictors of mortality in patients with heart failure, but could also be successful indicators in the determination between simple and severe acute cholecystitis (1, 13, 14). NLR represents a combination of two markers where neutrophils are the active non-inflammatory mediator initiating the first line of defense, where as lymphocytes represent the regulatory or protective component of inflammation (18, 19).…”

Section: Discussionmentioning

confidence: 99%

“…Previously proposed white blood cell count (WBC) and CRP as indicators of severity of acute cholecystitis are insufficient because in some patients those parameters can be within a normal reference range. In some studies, it was suggested that raised NLR can be associated with severity of cholecystitis and prolonged hospitalization after surgery (1, 2, 12, 13, 14).…”

Section: Introductionmentioning

confidence: 99%

Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Telo

Kuluöztürk

Deveci

et al. 2018

Journal of Medical Biochemistry

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SummaryBackground: The aim of this study was to determine the level of serum cystatin C (CysC) in patients with Chronic Obstructive Pulmonary Disease (COPD) during exacerbation and stable periods and to investigate its potential diagnostic value and the relationship between CysC levels and the pulmonary function test (PFT). Methods: One hundred twenty-six patients with COPD (68 in stable periods, 58 during exacerbation periods) and 50 healthy subjects were included in the study. PFT, body mass index (BMI), white blood cell counts, C-reactive protein (CRP), serum urea and creatinine levels were evaluated in both groups of patients. CysC levels were measured in all participants. Results: Serum CysC levels were statistically higher in both COPD groups than the control group (p<0.001 for both) although there was no statistically significant difference between COPD groups (p>0.05). CysC levels showed negative correlation with forced expiratory volume in 1 second (FEV 1 ) and a positive correlation with C-reactive protein (CRP) levels in patients with stable COPD. There was a positive correlation between serum CysC levels and serum urea, creatinine, CRP levels in patients with COPD exacerbation (r=0.333, p=0.011; r=0.260, p=0.049; r=0.414, p<0.01 respectively). When stable COPD and control groups were evaluated, serum CysC had an area under the curve (AUC) in the receiver operating characteristic (ROC) curve of 0.951 (0.909-0.994 95% CI: p<0.001).

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“…Surgical trauma elicits marked changes in cytokine levels, impaired metabolic response and increase of acute phases proteins (4). Inflammatory response of the body in perioperative period is a protective mechanism which promotes better recovery, while excessive inflammatory response in severe tissue injury could contribute to development of complications and impaired wound healing (5). During the adaptation on surgical stress negative nitrogen balance provokes peripheral fat utilization and leads to increase in glucose production.…”

Section: Introductionmentioning

confidence: 99%

Influence of IL-6, TNF-α and hs-CRP on Insulin Sensitivity in Patients after Laparoscopic Cholecystectomy or Open Hernia Repair

Mićić

Lalić

Djukić

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundThe aim of this study was to investigate the influence of IL-6, TNF-α and hs-CRP on insulin sensitivity during postoperative follow-up in patients with laparoscopic cholecystectomy (LC) or open hernia repair (OHR).Methods65 patients were studied: after laparoscopic cholecystectomy (LC; n=40) or open hernia repair (OHR; n=25). Glucose, insulin, hs-CRP, IL-6 and TNF-a were determined at day 0 (before the operation) and at days 1, 3 and 7 (after the operation).ResultsThere were no difference between LC and OHR groups concerning age, BMI, glucose, insulin, hs-CRP, IL-6 and TNF-α at day 0. hs-CRP increased at day 1, 3 and 7 vs. day 0 (p<0.0005), without difference between groups (p=0.561). IL-6 increased at day 1 and day 3 vs. day 0 (p<0.005). IL-6 was higher at day 1 in OHR group in comparison with LC group (p=0.044). There were no differences in TNF-a levels between LC and OHR groups (p=0.056). There was increase of HOMA-IR at day 1, 3 and 7 vs. day 0 (p<0.0005) in both groups. Significantly higher increase of HOMA-IR was in OHR group compared with LC group at day 1 (p=0.045). There was a positive correlation between hs-CRP and HOMA-IR (r=0.46; p=0.025) and between IL-6 and HOMA-IR at day 1 in OHR group (r=0.44; p=0.030).ConclusionsSignificantly higher HOMA-IR was found in OHR group compared with LC. Positive correlation between hs-CRP and IL-6 with HOMA-IR in OHR group at day 1, indicate possible influence of this mediators on impairment of insulin sensitivity.

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Influence of Syrgical Trauma on Nitric Oxide and Nitrotyrosine Serum Levels in Patients Undergoing Laparoscopic or Conventional Cholecystectomy

Cited by 4 publications

References 16 publications

Intraoperative Peritoneal Interleukin-6 Concentration Changes in Relation to the High-Mobility Group Protein B1 and Heat Shock Protein 70 Levels in Children Undergoing Cholecystectomy

Intraoperative Peritoneal Interleukin-6 Concentration Changes in Relation to the High-Mobility Group Protein B1 and Heat Shock Protein 70 Levels in Children Undergoing Cholecystectomy

Serum Cystatin C Levels in COPD: Potential Diagnostic Value and Relation Between Respiratory Functions

Influence of IL-6, TNF-α and hs-CRP on Insulin Sensitivity in Patients after Laparoscopic Cholecystectomy or Open Hernia Repair

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