Inhaled Furosemide Inhibits Cough Induced by Low Chloride Content Solutions but Not by Capsaicin

Ventresca, Pietro; Nichol, G.; Barnes, Peter J.; Chung, KF

doi:10.1164/ajrccm/142.1.143

Cited by 118 publications

(58 citation statements)

References 5 publications

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“…2), each corresponding to a definite fraction of the maximum available output [55,57]. Alternatively, the stimulus strength can be augmented progressively with constant nebuliser output, using nebulising solutions that are progressively lower in anion concentration [61][62][63].…”

Section: Dosing Schedulementioning

confidence: 99%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

613

619

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Section: Dosing Schedulementioning

confidence: 99%

ERS guidelines on the assessment of cough

Morice¹,

Fontana²,

Belvisi³

et al. 2007

Eur Respir J

613

619

View full text Add to dashboard Cite

“…In 10 normal subjects, we performed cough challenges with low-chloridecontent and capsaicin solutions [18]…”

Section: Validation Of Cough Eventsmentioning

confidence: 99%

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Hsu¹,

Stone²,

et al. 1994

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C Co ou ug gh hi in ng g f fr re eq qu ue en nc cy y i in n p pa at ti ie en nt ts s w wi it th h p pe er rs si is st te en nt t c co ou ug gh h: : a as ss se es ss sm me en nt t u us si in ng g a a 2 24 4 h ho ou ur r a am mb bu ul la at to or ry y r re ec co or rd de er r ABSTRACT: Cough is an important symptom of many respiratory disorders. We determined the frequency and diurnal variation of cough in normal subjects and in patients with asthma or with persistent cough of unknown cause. We used a portable, solid-state, multiple-channel recorder to record cough sounds over a 24 h period. The audio-signal was recorded from a unidirectional microphone strapped over the chest wall, and electromyographic (EMG) signals from the lower respiratory muscles were simultaneously registered with surface electrodes. The recorded digital data were examined on an IBM-compatible computer, and the typical signals induced by cough (as assessed by voluntary or experimentally-induced cough) were counted.In 12 normal subjects, only 0-16 coughs were recorded over 24 h. In 21 stable asthmatics with a history of chronic cough ("asthma") the median number was 282 (ranges: 45-1,577), and in 14 patients with the predominant symptom of daily dry coughs ("chronic coughers") the median number was 794 (64-3,639). In both groups of patients, there was a diurnal variation of coughs, such that the least numbers occurred between 2 and 5 a.m. (<3% of total). In the asthma group, there was no significant correlation between forced expiratory volume in one second (FEV 1 ) (% predicted) or diurnal variation of peak expiratory flow and cough frequency. In the chronic coughers, there was a significant correlation between daytime cough numbers and daytime cough symptom scores but not for the night-time values.Our data show that cough frequency is not determined by the severity of asthma in relatively stable asthmatics on inhaled steroids, and is reduced during sleep in both asthmatics and chronic cough patients. This portable cough recorder may be useful in the assessment of drug therapy for chronic cough.

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“…If this is accepted, it should also follow that agents capable of diminishing the activity of these endings should be effective in controlling the cough reflex. Considerations of this nature have been validated in the case of furosemide which attenuates cough [30] as well as laryngeal RAR activation induced, in the dog, by low chloride solutions [31]. Similar results were found for Aδ fibres, possibly corresponding to RARs, in an in vitro preparation of guinea-pig trachea [32].…”

Section: Discussionmentioning

confidence: 57%

Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog

Sant’Ambrogio¹,

Sant'Ambrogio²

1998

Eur Respir J

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Moguisteine is an antitussive agent with a novel chemical structure [1]. Its pharmacological activity has been tested on experimental animals and in several clinical trials. In guinea-pigs, moguisteine was found to reduce cough elicited by citric acid inhalation and electrical stimulation of the airway mucosa as effectively as codeine and dextromethorphan [2]. Moguisteine, injected into the cerebral ventricles of guinea-pigs, does not inhibit electrically stimulated cough, which is, instead, effectively blocked by intraventricular codeine: these findings suggest that the antitussive action of moguisteine depends on a peripheral mechanism [3]. Naloxone, a known narcotic antagonist, reverses the antitussive effects of codeine, but not those of moguisteine, indicating that the effects of moguisteine do not involve any interaction with opiate receptors. The antitussive action of moguisteine is also accompanied by clear anti-inflammatory effects in conditions characterized by bronchial hyperreactivity, airway leucocyte recruitment and airway microvascular leakage [4,5]. These anti-inflammatory effects of moguisteine have been found to be as strong as those of dexamethasone [4,5]. Several clinical trials have substantiated the beneficial effects of moguisteine on coughs of various nature: upper airway infection, chronic bronchitis, pulmonary fibrosis and tumours [6][7][8][9][10][11].Since cough is a reflex response elicited through the activation of specialized receptors activated by exogenous irritants and/or spontaneously occurring pathological conditions, the antitussive action of moguisteine could be viewed as dependent on an inhibitory effect on rapidly adapting irritant receptors (RARs). Indeed, the aim of this study was to investigate the possible effect of moguisteine on the activity of tracheobronchial RARs.RARs, as first identified by KELLER and LOESER [12] and later characterized with single fibre recordings by KNOWLTON and LARRABEE [13], represent a group of airway stretch receptors that respond to maintained lung in-flation and deflation with a rapidly adapting discharge at a highly irregular pattern of discharge. The rate of adaptation varies considerably among RARs, with the most rapidly adapting endings responding only during changes in stretch with a behaviour similar to Pacinian corpuscles, showing a clear off-response at the removal of the stim-ulus [14]. RARs are very responsive to intraluminal stim-uli, mechanical probing of the mucosa, inhalation of inert dust, inflammatory mediators and oedema of the airway walls [15]; for this reason they have also been called irritant receptors [16]. The mechanosensitivity (response to inflation) of RARs is second only to that of slowly adapting receptors and higher than that of pulmonary and bronchial C-fibre endings [17].RARs of similar nature are located superficially within the mucosa of both larynx and tracheobronchial tree [18]. RARs located in the large extrapulmonary tracheobronchial airways (trachea, main stem bronchi and proximal When the results a...

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Inhaled Furosemide Inhibits Cough Induced by Low Chloride Content Solutions but Not by Capsaicin

Cited by 118 publications

References 5 publications

ERS guidelines on the assessment of cough

ERS guidelines on the assessment of cough

Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder

Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog

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