Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts

Jeong, Ji‐Cheon; Kang, Suk‐Ku; Youn, Cheol-Ho; Jeong, Chang-Whan; Kim, Hyung-Min; Lee, Young Choon; Chang, Young‐Chae; Kim, Cheorl-Ho

doi:10.1016/j.intimp.2003.08.003

Cited by 46 publications

(54 citation statements)

References 47 publications

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“…Rhizoma Drynariae and its bioactive constituents were able to promote the osteoblastic proliferation, differentiation, and maturation (56,58,59,(62)(63)(64)(65)(66)(67)(68)(69)(70), inhibit osteoblastic apoptosis (71), suppress osteoclastogenesis (72)(73)(74), promote the apoptosis of osteoclasts (60), stimulate both cellular and humoral immunity (75), and inhibit cathepsins K processing (76,77).…”

Section: In Vitro Preclinical Datamentioning

confidence: 99%

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin

Wang

Zhang

et al. 2017

BST

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Section: In Vitro Preclinical Datamentioning

confidence: 99%

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin

Wang

Zhang

et al. 2017

BST

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“…Several studies have reported that herbs or herbal formulas originally used in TCM to tonify kidney function have positive effects on bone metabolism by directly inhibiting osteoclast differentiation [17] or resorption [34] or by regulating osteoblast-dependent osteoclastogenesis [35]. Regulation of the RANKL signaling on osteoclastogenesis has been suggested as one of the mechanisms by which herbal medicines tonifying kidney essence affect bone metabolism [36]. Thus, WEMV inhibition of the RANKL signaling pathway and bone resorption may be the molecular mechanism by which WEMV affects bone metabolism in addition to its pharmaceutic effect to strengthen kidney function in TCM.…”

Section: Discussionmentioning

confidence: 99%

A water extract of Malva verticillata seeds suppresses osteoclastogenesis and bone resorption stimulated by RANK ligand

Shim

2016

Planta Med

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Background: Malva verticillata seeds are used as a therapeutic medicine to treat kidney dysfunction in traditional Chinese medicine (TCM). TCM has suggested that herbal medicine tonifying kidney function may have beneficial effect on bone metabolism. Methods: Osteoclastogenesis was examined in bone marrow macrophages by measuring tartrate-resistant acid phosphatase (TRAP) activity and counting the number of TRAP-stained multinuclear cells. The activation of receptor activator of nuclear factor-kB (RANK) ligand signaling, and the expression of c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) were investigated by western blot analysis. Transcription factor and bone resorption marker mRNA levels were evaluated using real-time quantitative polymerase chain reaction. The bone resorption activity of mature osteoclast was examined in osteoclasts cultured on a hydroxyapatite-coated culture plate.

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“…Current research on rhizoma drynariae extract indicated that it can enhance the proliferation and osteogenic differentiation of the MC3T3-E1 cell line [15] and inhibit osteoclast formation [16]. Based on the above, it seems that rhizoma drynariae has the potential therapeutic function for osteolysis-induced aseptic loosening.…”

Section: Introductionmentioning

confidence: 95%

Inhibiting wear particles-induced osteolysis with naringin

Zhao²,

et al. 2012

International Orthopaedics (SICOT)

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Purpose The purpose of this study was to determine the effects of naringin on osteoclastogenesis and osteolysis both in vitro and in vivo. Methods In this research osteoclasts were generated from mouse bone marrow monocytes with the receptor activator of NF-КB ligand and the macrophage colony stimulating factor. Naringin, at a concentration of 1, 10, 50, and 100 μg/ mL, was respectively added to the medium. Seven days later, the osteoclasts were determined through tartrateresistant acid phosphatase (TRAP) staining. Mature osteoclasts were isolated from newborn rabbits and cultured for three days on bone slices. Naringin at a concentration of 1, 10, 50, and 100 μg/mL was respectively added to the medium. The resorption bone slices were quantified, and the area was calculated after toluidine blue and Mayerhematoxylin staining. Polymethyl methacrylate (PMMA) particles were implanted on the calvariae of C57BL/J6 mice. Naringin, at a dose of 50 μg/kg and 100 μg/kg, was respectively given intraperitoneally for seven. Seven days later, the calvariae were removed and processed for pathological analysis.Results The result indicated that naringin treatment effectively inhibited in vitro osteoclastogenesis and inhibited mature osteoclasts. In vivo data indicated that naringin strongly inhibited PMMA-induced osteolysis. Conclusion Naringin can effectively inhibit osteoclastogenesis and suppress wear particles-induced osteolysis and might be useful in the treatment or prevention of wear particles-induced osteolysis and aseptic loosening for its effect on osteoclast generation and function.

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Inhibition of Drynariae Rhizoma extracts on bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts

Cited by 46 publications

References 47 publications

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

A water extract of Malva verticillata seeds suppresses osteoclastogenesis and bone resorption stimulated by RANK ligand

Inhibiting wear particles-induced osteolysis with naringin

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