Inhibition of Experimental Caries by Sodium Metabisulfite and its Effect on the Growth and Metabolism of Selected Bacteria

Jordan, H.V.; Fitzgerald, Robert J.; Bowler, Ann E.

doi:10.1177/00220345600390010501

Cited by 131 publications

(52 citation statements)

References 10 publications

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“…Implantation of SL-I, a human plaque isolate, or E-49, a streptomycin resistant variant of hamster plaque isolate HS-6 (Fitzgerald & Keyes, 1960 (Jordan, Fitzgerald & Bowler, 1960) supplemented with 50 mg. Na,CO,/l. and 5 % (wlv) sucrose.…”

Section: Micro-organismsmentioning

confidence: 99%

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Linear Growth Kinetics of Plaque-forming Streptococci in the Presence of Sucrose

Tanzer

Wood

Krichevsky

1969

Journal of General Microbiology

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Growth of intact plaques of dextran-forming strain SL-I was linear both on a dry weight and DNA basis. Growth of broth cultures of dextran-forming strains SL-I and E-49 was linear with sucrose but exponential with other sugars; non dextran-forming strains 4M4 and JR8LG grew exponentially with all sugars tested. When dextranase was added to slowly growing cultures of dextran-forming strains SL-I and E-49, growth became rapid. Linear growth of strains SL-I and E-49 with sucrose is ascribable to extracellular dextran synthesized by the organisms.

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Section: Micro-organismsmentioning

confidence: 99%

“…Cells were grown initially in broth (Jordan et al 1960) supplemented with 50 mg. Na,CO,/l. and containing an appropriate concentration of filter-sterilized sugar.…”

Section: Micro-organismsmentioning

confidence: 99%

Linear Growth Kinetics of Plaque-forming Streptococci in the Presence of Sucrose

Tanzer

Wood

Krichevsky

1969

Journal of General Microbiology

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“…20 nichrome wires, using a slight modification of methods previously detailed (44,45). Fluid thioglycolate cultures were used to inoculate a complex medium (24) supplemented with 5% (wt/ vol) sucrose and 0.005% (wt/vol) sodium carbonate. The nichrome wires, fixed to culture tube closures, were transferred daily to fresh medium until the wire-adherent microorganisms (in vitro plaques) had grown to a rating of 3 to 4 as judged by the method of McCabe et al (32).…”

mentioning

confidence: 99%

In Vitro Evaluation of Three Iodine-Containing Compounds as Antiplaque Agents

Tanzer

Slee

Kamay

et al. 1977

Antimicrob Agents Chemother

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The antibacterial activity of three iodine-containing compounds was determined for strains of four dental plaque-forming microorganisms, using an in vitro preclinical plaque model system. Solutions of inorganic iodine, povidone-iodine, and Wescodyne were tested for antiplaque activity against preformed plaques of a number of strains of Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus , and Actinomyces naeslundii . Solutions of inorganic iodine were more effective as antiplaque agents, with respect to minimal bactericidal concentration and time and frequency of treatments, than solutions of Wescodyne and povidone-iodine. Inorganic iodine appeared to be particularly effective against the most cariogenic ( S. mutans ) and periodontopathic ( A. viscosus ) organisms while allowing survival of the least orally pathogenic plaque-forming microorganism ( S. sanguis ). It is suggested that topical application of solutions of inorganic iodine may be useful in controlling dental caries and actinomyces-associated periodontal disease.

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“…The lesions which developed were located in the molar sulci, most frequently in the first and second mandibular molars. Diet 585 is composed of 30% whole milk powder (Land O'Lakes), 42% yellow hominy 296 grits (Quaker Oats Co.), 25% granulated sucrose (Domino), 2% whole liver powder (Wilson Laboratories), and 1% salt mixture (25 (12), in which the glucose concentration was 0.4%.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Experimental Dental Caries by Antibiotics

Fitzgerald

1972

Antimicrob Agents Chemother

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A variety of antibiotic and chemotherapeutic agents were tested for their ability to inhibit the development of dental caries in Sprague-Dawley rats receiving the drugs in a coarse-particle sucrose-containing diet. Drugs which inhibit gram-positive microorganisms were effective inhibitors of caries, whereas agents which are active solely against gram-negative bacteria did not inhibit caries development. In vivo efficacy of the agents tested generally, but not invariably, paralleled in vitro inhibition of the growth of Streptococcus mutans strain FA-1, an organism which was isolated from carious Sprague-Dawley rats and which is known to induce caries in gnotobiotic Sprague-Dawley rats. Caries was significantly inhibited when 1-ephenamine penicillin (20 units/mg) was administered intermittently in the diet, 1 day per week or 1 week of every 4 weeks, but protection against caries was greatest when the same amount of the drug was fed continuously.

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Inhibition of Experimental Caries by Sodium Metabisulfite and its Effect on the Growth and Metabolism of Selected Bacteria

Cited by 131 publications

References 10 publications

Linear Growth Kinetics of Plaque-forming Streptococci in the Presence of Sucrose

Linear Growth Kinetics of Plaque-forming Streptococci in the Presence of Sucrose

In Vitro Evaluation of Three Iodine-Containing Compounds as Antiplaque Agents

Inhibition of Experimental Dental Caries by Antibiotics

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