Inhibition of neurotrophic activity in salamanders treated with opioids

Smith, Alvy Ray; Hui, Ferdinand W.

doi:10.1016/0014-4886(73)90039-3

Cited by 14 publications

(2 citation statements)

References 12 publications

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“…Also, TENS is usually employed to control neuropathic pain ( Leem et al, 1995; Hanai, 2000; Nam et al, 2001; Cheing and Luk, 2005; Somers and Clemente, 1998; 2003; 2006 ) , which is often associated with peripheral nerve lesions and sometimes WD ( Latinovic et al, 2006 ) . TENS analgesic effects are related to the release of endogenous opioids ( Sluka and Walsh, 2003 ) ; this is related to another controversy on its use to improve nerve regeneration because chronic opioid exposure may be associated with tolerance and inhibition of various steps of the peripheral nerve restoration process ( Smith and Hui, 1973; Sinatra and Ford, 1979; Sinatra et al, 1979; Zeng et al, 2007 ) .…”

Section: Introductionmentioning

confidence: 99%

High‐ and low‐frequency transcutaneous electrical nerve stimulation delay sciatic nerve regeneration after crush lesion in the mouse

Baptista

Gomes²,

Oliveira³

et al. 2008

J Peripheral Nervous Sys

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The stimulation of peripheral nerve regeneration has been studied in different ways, including the use of electrical fields. The capacity of this modality to enhance nerve regeneration is influenced by the parameters used, including current type, frequency, intensity, and means of administration. Transcutaneous electrical nerve stimulation (TENS) is a frequently used form of administering electrical current to the body, but its effects on peripheral nerve regeneration are not known. This study assessed the influence of TENS on sciatic nerve regeneration, using a model of crush lesion in the mouse. Mice were stimulated 30 min a day, 5 days a week, for 5 weeks with both high- (100 Hz) and low- (4 Hz) frequency TENS. Control animals had the sciatic nerve crushed but were not stimulated. Assessment was performed weekly by functional analysis using the Static Sciatic Index for the mouse and at the end of the experiment by light and electron microscopy. The results showed that although there were no differences between the groups regarding the Static Sciatic Index values, TENS led to nerves with morphological signs of impaired regeneration. At light microscopy level, TENS nerves presented more axons with dark axoplasm, signs of edema, and a less organized cytoarchitecture. Electronmicrographs showed fewer and thinner thick myelinated fibers and increased number of Schwann cell nuclei. Myelinated axon diameters and density and diameter of nonmyelinated fibers were not affected by TENS, leading to the conclusion that this regimen of electrical stimulation leads to a delayed regeneration after a crush lesion of the sciatic nerve in the mouse. All these effects were more pronounced on high-frequency TENS nerves.

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Section: Introductionmentioning

confidence: 99%

High‐ and low‐frequency transcutaneous electrical nerve stimulation delay sciatic nerve regeneration after crush lesion in the mouse

Baptista

Gomes²,

Oliveira³

et al. 2008

J Peripheral Nervous Sys

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“…The first study on true regeneration was performed in 1973 in salamander and showed that opioid treatment after amputation inhibited hind limb regeneration while treatment with the opioid receptor antagonist naloxone accelerated the limb regeneration. This study thus suggests a deleterious effect of both medical treatments with opioids and endogenous opioids on regeneration [ 17 ]. Another study dealt with the regeneration of the pancreatic epithelium in induced pancreatitis in mice [ 18 ], showing that morphine prevented epithelium regeneration.…”

Section: Tissue Repair: Scar Healing Versus Regenerationmentioning

confidence: 99%

Tissue Regeneration: The Dark Side of Opioids

Berthézène

Rabiller

Jourdan

et al. 2021

IJMS

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Opioids are regarded as among the most effective analgesic drugs and their use for the management of pain is considered standard of care. Despite their systematic administration in the peri-operative period, their impact on tissue repair has been studied mainly in the context of scar healing and is only beginning to be documented in the context of true tissue regeneration. Indeed, in mammals, growing evidence shows that opioids direct tissue repair towards scar healing, with a loss of tissue function, instead of the regenerative process that allows for recovery of both the morphology and function of tissue. Here, we review recent studies that highlight how opioids may prevent a regenerative process by silencing nociceptive nerve activity and a powerful anti-inflammatory effect. These data open up new perspectives for inducing tissue regeneration and argue for opioid-restricted strategies for managing pain associated with tissue injury.

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The effects of acute and chronic morphine treatment on the process of facial nerve regeneration

Sinatra

Ford

1979

Brain Research

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Inhibition of neurotrophic activity in salamanders treated with opioids

Cited by 14 publications

References 12 publications

High‐ and low‐frequency transcutaneous electrical nerve stimulation delay sciatic nerve regeneration after crush lesion in the mouse

High‐ and low‐frequency transcutaneous electrical nerve stimulation delay sciatic nerve regeneration after crush lesion in the mouse

Tissue Regeneration: The Dark Side of Opioids

The effects of acute and chronic morphine treatment on the process of facial nerve regeneration

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