Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products

Yoshida, Naoko; Koizumi, Mariya; Adachi, Isao; Kawakami, Junichi

doi:10.1016/j.fct.2006.07.003

Cited by 75 publications

(56 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our preliminary experiments for the present report, MRP2-or BCRP-mediated transport was attempted to be evaluated by the whole cell-based assay such as the intracellular accumulation and transcellular transport studies as shown in our previous reports (Yoshida et al, 2005(Yoshida et al, , 2006a. However, an active efflux via these transporters was not shown probably because of the high hydrophilicity of the specific substrate used ([ 3 H]E 2 17␤G).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Yoshida¹,

Takada²,

Yamamura³

et al. 2008

Drug Metab Dispos

Self Cite

View full text Add to dashboard Cite

ABSTRACT:The possibility of interactions between natural products/supplements and conventional prescription medicines is one of the most important issues in pharmacotherapeutic safety. Recently, we reported that some terpenoids such as (R)-(؉)-citronellal and glycyrrhetic acid, which are present in herbal medicines, can act as inhibitors of P-glycoprotein (MDR1/ABCB1). In the present study, the effects of seven terpenoids on multidrug resistance-associated protein 2 (MRP2/ABCC2) and breast cancer resistance protein (BCRP/ ABCG2)-mediated transport were investigated in vitro. Membrane vesicles were prepared from MRP2 cDNA transfected Sf9 cells derived from pupal ovarian tissue of Spodoptera frugiperda, a fall armyworm, and BCRP cDNA transfected LLC-PK1 cells derived from porcine kidney. MRP2-or BCRP-mediated efflux transport was measured as ATP-dependent accumulation of [ 3 H]estradiol 17-␤-D-glucuronide (E 2 17␤G) into membrane vesicles collected by a rapid filtration technique. The effects of (R)-(؉)-citronellal, (S)-(؊)-␤-citronellol, ␣-terpinene, terpinolene, (؊)-␤-pinene

show abstract

Section: Discussionmentioning

confidence: 99%

“…In the present study, the inhibitory effects of seven terpenoids (Fig. 1) that can be P-gp inhibitors (Yoshida et al, 2006a) on MRP2-and BCRP-mediated transport were investigated using membrane vesicles.…”

mentioning

confidence: 99%

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Yoshida¹,

Takada²,

Yamamura³

et al. 2008

Drug Metab Dispos

Self Cite

View full text Add to dashboard Cite

show abstract

“…3 H] digoxin; however other terpenoids such as citronellal, b-citronellol, a-terpinene, terpinolene, b-pinene, abietic acid, ophiobolin A, cucurbitacin I, and glycyrrhetic acid inhibited the P-gp mediated efflux of [29]. In this study, the ENFX + limonene group did not show a significant influence on the absorption of ENFX compared with the group treated with ENFX alone except for MAT.…”

mentioning

confidence: 67%

“…Many studies have reported that grapefruit -Note-juice and orange juice is able to inhibit P-gp [3,6,8,10,19]. Moreover, crude drugs or natural herbs containing various terpenoids and flavonoids can be considered to affect the bioavailability of concomitant P-gp substrates or OATP inhibitors after oral administration [29].…”

mentioning

confidence: 99%

Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats

Lim¹,

Kim

Hwang

et al. 2012

Exp. Anim.

View full text Add to dashboard Cite

This study was conducted to evaluate the oral absorption of enrofloxacin (ENFX) in rats when administered with orange oil or its main component, limonene. Compared with the group administered ENFX alone, the ENFX + limonene group did not show any significant difference in the absorption of ENFX, whereas the extent and rate of absorption of ENFX were significantly decreased in the ENFX + orange oil group (C max , -43%; T max , 129%). In addition, t 1/2λz and MRT of ENFX were prolonged by the concomitant administration of orange oil. The AUCs of ENFX were not affected in the ENFX + orange oil group. These results suggest that decreased oral absorption could reduce the efficacy of ENFX therapy in animals.

show abstract

“…Recent findings have shown that these compounds interact with transporter proteins to inhibit drug efflux mediated by MDR1, MRP1 or BCRP. In particular, triterpenoids can act with different mechanisms, including direct interaction with the Pglycoprotein (P-gp) active site, stimulating the activity of the P-gp ATPase [33], or decreasing P-gp expression in a dose-dependent manner [34].…”

Section: Terpenes and Terpenoids Isolated From Plantsmentioning

confidence: 99%

Natural Compounds: Molecular Weapons against Leukemia’s

Taverna¹,

Corrado

2017

J Leuk

View full text Add to dashboard Cite

Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones.A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis.Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.

show abstract

Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products

Cited by 75 publications

References 28 publications

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Effect of Orange Oil on the Oral Absorption of Enrofloxacin in Rats

Natural Compounds: Molecular Weapons against Leukemia’s

Contact Info

Product

Resources

About