Inhibitory Effect of Acteoside Isolated from<i>Cistanche tubulosa</i>on Chemical Mediator Release and Inflammatory Cytokine Production by RBL-2H3 and KU812 Cells

Yamada, Parida; Iijima, Rieko; Han, Jianzhong; Shigemori, Hideyuki; Yokota, Shinichi; Isoda, Hiroko

doi:10.1055/s-0030-1249775

Cited by 41 publications

(25 citation statements)

References 38 publications

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“…[4,5]. Acteoside has been found to have antioxidative, anti-inflammatory, anti-nociceptive, anti-metastatic, hepatoprotective and cytoprotective activities [6,7,8,9,10,11,12]. Reports have shown that acteoside can alleviate acquired learning disability in mice that is induced by scopolamine [13], and reduce cerebral injury in mice that is induced by d -galactose [14,15].…”

Section: Introductionmentioning

confidence: 99%

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

Shiao

Lin

et al. 2017

IJMS

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Acteoside and isoacteoside, two phenylethanoid glycosides, coexist in some plants. This study investigates the memory-improving and cytoprotective effects of acteoside and isoacteoside in amyloid β peptide 1-42 (Aβ 1-42)-infused rats and Aβ 1-42-treated SH-SY5Y cells. It further elucidates the role of amyloid cascade and central neuronal function in these effects. Acteoside and isoacteoside ameliorated cognitive deficits, decreased amyloid deposition, and reversed central cholinergic dysfunction that were caused by Aβ 1-42 in rats. Acteoside and isoacteoside further decreased extracellular Aβ 1-40 production and restored the cell viability that was decreased by Aβ 1-42 in SH-SY5Y cells. Acteoside and isoacteoside also promoted Aβ 1-40 degradation and inhibited Aβ 1-42 oligomerization in vitro. However, the memory-improving and cytoprotective effects of isoacteoside exceeded those of acteoside. Isoacteoside promoted exploratory behavior and restored cortical and hippocampal dopamine levels, but acteoside did not. We suggest that acteoside and isoacteoside ameliorated the cognitive dysfunction that was caused by Aβ 1-42 by blocking amyloid deposition via preventing amyloid oligomerization, and reversing central neuronal function via counteracting amyloid cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

Shiao

Lin

et al. 2017

IJMS

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“…β-Hex, which is stored in the secretiory granules of mast cells is released concomitantly with histamine when mast cells are immunologically activated (Ortega et al 1988;Schroeder et al 1995). Thus, β-hex activity in the medium is used as a marker of mast cell degranulation (Yamada et al, 2010). Therefore, RBL-2H3 cells are considered as a good tool for studying the effect of environmental pollutant on chemical mediator release activity.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents

Yamada¹,

Hatta²,

Du³

et al. 2012

Ecotoxicology and Environmental Safety

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“…On the other hand, Cistanche tubulosa (CT) has also been widely used for traditional medication in China. It was reported that CT extract lower the production of TNF-á and IL-4 that are major factors for NO production in inflammatory pathway [19]. …”

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confidence: 99%

Synergistic anti-inflammatory effects ofLaminaria japonicafucoidan andCistanche tubulosaextract

et al. 2012

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The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system and in vivo carrageenan-induced air pouch inflammation model. CT extract inhibited nitric oxide production from activated RAW 264.7 macrophage cells, while fucoidan was inactive. In vivo air pouch inflammation model, carrageenan-induced vascular exudation and increased nitric oxide and prostaglandin E2 concentrations in the exudates were synergistically suppressed by co-administration of fucoidan or CT extract. Moreover, tissue inflammation was substantially attenuated by the combinational therapy. However, there was no synergistic effect against the inflammatory cell infiltration, although fucoidan and CT extract each markedly reduced the cell numbers. Therefore, it is suggested that fucoidan blocks infiltration of inflammatory cells, while CT extract inhibits activation of the cells, and that their combinational treatment could be a promising candidate for the relief of various types of inflammation.

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Inhibitory Effect of Acteoside Isolated fromCistanche tubulosaon Chemical Mediator Release and Inflammatory Cytokine Production by RBL-2H3 and KU812 Cells

Cited by 41 publications

References 38 publications

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo

Inflammatory and degranulation effect of yellow sand on RBL-2H3 cells in relation to chemical and biological constituents

Synergistic anti-inflammatory effects ofLaminaria japonicafucoidan andCistanche tubulosaextract

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