Injectable Hydrogel for Cu2+ Controlled Release and Potent Tumor Therapy

Abstract

Disulfiram (DSF) is an important drug for the treatment and management of alcohol dependency. This drug has been approved by US-FDA, and its activity against the tumor is dependent on copper ion (Cu2+). However, the copper toxicity (caused via external copper) and its intrinsic anfractuous distribution in the human body have adversely suppressed the mechanism of DSF in in vivo. In this study, we aimed to design an injectable hydrogel, as CRC (Cu2+ release controller) for the effective treatment of tumors. The hydrogels of agarose have been used for wrapping of CuCl2, and hierarchical microparticles (HMP) for the generation of CRC system. When the laser irradiations (808 nm) have been provided to the system, light energy is transferred into heat energy, which results in the hydrogel hydrolysis (reversible) due to the overheating effect. This is followed by a reaction with DSF (pre-injected) to suppress tumor progression. Hence, the CRC system brings innovative ideas for designing of a Cu2+ delivery system.

A Novel H2O2 Generator for Tumor Chemotherapy-Enhanced CO Gas Therapy

“…During this study, no weight changes were detected in the treatment group, indicating no significant systemic toxicity ( Figure 3C ). This is crucial since many treatments have clear systemic toxicity, which significantly decreases their potential utility ( 34 – 37 ). We used the FL-Co-1 + PdCl 2 fluorescence probe to detect the CO content of tumors, confirming that combining CPT and MnCO in ZCM greatly enhanced CO generation in the tumor.…”

Cu-Hemin Nanosheets and Indocyanine Green Co-Loaded Hydrogel for Photothermal Therapy and Amplified Photodynamic Therapy

“…Although the traditional intravenous injection of nanomaterials to the tumor site improves the therapeutic efficiency to a certain extent, the uncontrollable release of nanomaterials and the complex physiological environment of the body make the accumulation of nanocarriers in tumor tissue still less than 10% (30)(31)(32). Macroscopic drug delivery systems such as light-responsive hydrogels (LRH) are promising smart controlled release systems (33)(34)(35). The hydrogel-carrying nanomaterials can aggregate at the tumor site and achieve almost 100% drug penetration (31).…”

Injectable Hydrogel System for Camptothecin Initiated Nanocatalytic Tumor Therapy With High Performance

“…Local therapeutic drug delivery is an attractive alternative to systemic intravenous drug delivery, enabling researchers to achieve sustained and precise release of nanomaterials without any risk of off-target toxicity ( 28 , 29 ). NIR light-responsive hydrogel is a satisfactory and controllable drug delivery platform ( 30 ). The hydrogel is gradually solidified after being injected into the tumor tissue.…”