Injectable polypeptide hydrogel/inorganic nanoparticle composites for bone tissue engineering

Huang, Wei-Shun; Chu, I‐Ming

doi:10.1371/journal.pone.0210285

Cited by 37 publications

(25 citation statements)

References 73 publications

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“…The combination of a magnetic hydrogel and an external magnetic field could be a promising approach for tissue engineering and bone regeneration. [160] Hydrogels can display stimulus-responsive drug release properties. Examples include temperature-responsive or NIRresponsive hydrogels.…”

Section: Nanoparticlesmentioning

confidence: 99%

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Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Ayoubi‐Joshaghani

Seidi

Azizi

et al. 2020

Adv Funct Materials

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Novel advanced hydrogels can provide a versatile platform for controlled delivery and release of various cargos, with a myriad of biomedical applications. These gel-based nanostructures possess good biocompatibility, biodegradability, flexibility, multifunctionality, can respond to internal or external stimuli, and can adapt to their surrounding environment. This new generation of hydrogels is not only capable of serving as targeted drug delivery vehicles, but they can also perform a variety of tasks within living cells and organisms. In this review, advanced hydrogels are classified as static, dynamic, multistage, or bioinspired. They can be used as cell-free gene expression platforms for gene therapy. Administration of nanogel-based sprays can act as an immunovaccine priming macrophages toward the M1 phenotype to avoid cancer recurrence following surgery. Nanogels can also serve as a dual biosensing and capture platform for liquid biopsies, and can recognize and remove circulating cancer cells from the blood of cancer patients.

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Section: Nanoparticlesmentioning

confidence: 99%

“…The combination of a magnetic hydrogel and an external magnetic field could be a promising approach for tissue engineering and bone regeneration. [ 160 ]…”

Section: Hydrogels In Biomedicinementioning

confidence: 99%

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Ayoubi‐Joshaghani

Seidi

Azizi

et al. 2020

Adv Funct Materials

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show abstract

“…This group suggested Gel-Ty/G-NAC hydrogels as a biodegradable platform in bone-related applications such as bone treatment, drug delivery, and cell delivery. In another effort, methoxy (polyethylene glycol)-polyalanine (mPA), as a di-block copolymer based thermo-responsive hydrogel, was incorporated by superparamagnetic Fe 3 O 4 (osteoinductive) and hydroxyapatite (osteoconductive) nanoparticles in various contents (Huang and Chu, 2019). Modulation of bone differentiation bio-markers, as well as bone mineralization enhancement, was the result of the inclusion of such nanoparticle combinations into the polypeptide hydrogel.…”

Section: Nc Hydrogelsmentioning

confidence: 99%

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

et al. 2020

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Since the introduction of tissue engineering as an encouraging method for the repair and regeneration of injured tissue, there have been many attempts by researchers to construct bio-mimetic scaffolds which mimic the native extracellular matrix, with the aim of promoting cell growth, cell proliferation, and restoration of the tissue's native functionality. Among the different materials and methods of scaffold fabrication, one particularly promising class of materials, hydrogels, has been extensively studied, with the inclusion of nano-scaled materials into hydrogels leading to the creation of an exciting new generation of nanocomposites, known as nanocomposite hydrogels. To closely mimic the native tissue behavior, scientists have recently focused on the functionalization of incorporated nanomaterials via chiral biomolecules, with reported results showing great potential. The current article aims to introduce a perspective of nano-scaled cellulose as a promising nanomaterial which can be multi-functionalized for the fabrication of nanocomposite hydrogels with applications in tissue engineering and drug delivery systems. This article also briefly reviews the recently reported literature on nanocomposite hydrogels incorporated with chiral functionalized nanomaterials. Such knowledge paves the path for the development of tailored hydrogels toward practical applications.

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“…The effect of an external moving magnetic field, applied simply by using a neodymium magnet, was evaluated on MC3T3-E1 cell cultures when superparamagnetic Fe 3 O 4 and nano-hydroxyapatite were simultaneously dissolved in methoxy(polyethylene glycol)-polyalanine for obtaining an injectable hydrogel [ 107 ]. The composite approach, that is, the internal and external magnetism, appeared particularly interesting.…”

Section: Magneto-responsive Scaffolds For Hard Tissue Regenerationmentioning

confidence: 99%

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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Injectable polypeptide hydrogel/inorganic nanoparticle composites for bone tissue engineering

Cited by 37 publications

References 73 publications

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Insight Into the Current Directions in Functionalized Nanocomposite Hydrogels

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

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