Insertions of antihypertensive peptides and their applications in pharmacy and functional foods

Morales-Camacho, Jocksan I.; Espinosa-Hernández, Edgar; Rosas-Cárdenas, F. Fátima; Semería-Maitret, Tamara; Luna-Suárez, Silvia

doi:10.1007/s00253-019-09633-1

Cited by 8 publications

(3 citation statements)

References 56 publications

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“…Among several bioactive peptides, ACE-inhibitory peptides have received substantial research, and some of these peptides, including IPP, VPP, IPA, PP, and GKP, have an antihypertensive activity [32,33]. According to previous reports, antihypertensive peptides are used as a successful therapeutic candidate for people with moderate hypertension or even a supplementary treatment [34]. Similar to this, the antihypertensive effects of IGLF and RVPSL peptides from egg white have been shown to reduce SBP in SHR rats [35].…”

Section: Discussionmentioning

confidence: 99%

VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α

Baskaran

Balasubramanian

et al. 2022

Molecules

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Hypertension is a chronic disease related to age, which affects tens of millions of people around the world. It is an important risk factor that causes myocardial infarction, heart failure, stroke, and kidney damage. Bioactive peptide VHVV (VH-4) from soybean has shown several biological activities. Physical exercise is a cornerstone of non-pharmacologic treatment for hypertension and has established itself as an effective and complementary strategy for managing hypertension. The present study evaluates the efficacy of VH-4 supplement and swimming exercise training in preventing hypertension in spontaneously hypertensive rats (SHR). SHR animals were treated with VH-4 (25 mg/kg by intraperitoneal administration) and swimming exercise (1 h daily) for eight weeks, and the hemodynamic parameters, histology, and cell survival pathway protein expression were examined. In SHR rats, increased heart weight, blood pressure, and histological aberrations were observed. Cell survival protein p-PI3K and p-AKT and antiapoptosis proteins Bcl2 and Bcl-XL expression decreased in SHR animals. SIRT1 and FOXO3 were decreased in hypertensive rats. Both bioactive peptide VH-4 treatment and swimming exercise training in hypertensive rats increased the cell survival proteins p-PI3K and p-AKT and AMPKα1, Sirt1, PGC1α, and FoX3α proteins. Soy peptide VH-4, along with exercise, acts synergistically and prevents hypertension by activating cell survival and AMPKα1, Sirt1, PGC1α, and FoX3α proteins.

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Section: Discussionmentioning

confidence: 99%

VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α

Baskaran

Balasubramanian

et al. 2022

Molecules

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“…More than one sixth of the blood pressure-lowering drugs used worldwide are angiotensin I-converting enzyme (ACE) inhibitors, such as captopril, because ACE is the key enzyme in the process of raising blood pressure in humans [91]. Drugs used to control high blood pressure can cause side effects; for this reason, much research has focused on finding alternatives to control or prevent this disease through diet [92]. There is an urgent need for new ACE inhibitors to treat hypertension, and inhibitors from natural sources are promising medicinal and edible supplements due to their efficacy and safety.…”

Section: Antihypertensive Activitymentioning

confidence: 99%

Improving the Sustainability of Processing By-Products: Extraction and Recent Biological Activities of Collagen Peptides

Zhao

Song

et al. 2023

Foods

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Society and consumers are increasingly concerned about food safety and the sustainability of food production systems. A significant amount of by-products and discards are generated during the processing of aquatic animals, which still needs to be fully utilized by the food industry. The management and sustainable use of these resources are essential to avoiding environmental pollution and resource waste. These by-products are rich in biologically active proteins, which can be converted into peptides by enzymatic hydrolysis or fermentation treatment. Therefore, exploring the extraction of collagen peptides from these by-products using an enzymatic hydrolysis technology has attracted a wide range of attention from numerous researchers. Collagen peptides have been found to possess multiple biological activities, including antioxidant, anticancer, antitumor, hypotensive, hypoglycemic, and anti-inflammatory properties. These properties can enhance the physiological functions of organisms and make collagen peptides useful as ingredients in food, pharmaceuticals, or cosmetics. This paper reviews the general methods for extracting collagen peptides from various processing by-products of aquatic animals, including fish skin, scales, bones, and offal. It also summarizes the functional activities of collagen peptides as well as their applications.

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“…It affects more than 30% of the world's adult population and is the main preventable risk factor for cardiovascular diseases (CVDs), as well as brain, heart, and kidney diseases, in addition to others. [2,3] In fact, the prevalence of HT in the adult population in the world ranges between 33% and 43%, and it increases with age, exceeding 60% among people aged over 65 years. [4] Furthermore, an increasing trend in HT has also been observed among young populations over the last two decades.…”

Section: Introductionmentioning

confidence: 99%

Potential Impact of Bioactive Peptides from Foods in the Treatment of Hypertension

Ichim,

Marín,

Orenes‐Piñero

2024

Molecular Nutrition Food Res

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ScopeHigh blood pressure (BP) is the main preventable risk factor for cardiovascular diseases (CVDs). Much research is aimed at finding natural alternatives to control or prevent hypertension (HT), since some hypertensive patients do not respond to current pharmacological treatments or show undesirable side effects.Methods and resultsForty relevant articles have been selected from various scientific literature databases. The results reveal that angiotensin‐converting enzyme (ACE) inhibition is the most reported mechanism of action of antihypertensive peptides. The active peptides have a great variety of origins. Biopeptides with a molecular weight of <3 kDa, short chain <20 amino acids, and a hydrophobic amino acid sequence at the C‐ and N‐terminus exhibit higher antihypertensive activity. They also show good stability to enzymatic hydrolysis and gastrointestinal digestion, and no toxicity. To determine antihypertensive effectiveness, in vitro and in vivo animal studies are the most frequent developed, with few in silico studies and only one human clinical trial.ConclusionThere is interesting potential for antihypertensive peptides as promising natural candidates for the development of functional foods, nutraceuticals and drugs for preventive or therapeutic treatment of hypertension. The aim of this review is to study the role of food‐derived bioactive peptides in HT.

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Insertions of antihypertensive peptides and their applications in pharmacy and functional foods

Cited by 8 publications

References 56 publications

VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α

VH-4-A Bioactive Peptide from Soybean and Exercise Training Constrict Hypertension in Rats through Activating Cell Survival and AMPKα1, Sirt1, PGC1α, and FoX3α

Improving the Sustainability of Processing By-Products: Extraction and Recent Biological Activities of Collagen Peptides

Potential Impact of Bioactive Peptides from Foods in the Treatment of Hypertension

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