Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity

Aye, Irving L.M.H.; Rosario, Fredrick J.; Kramer, Anita; Kristiansen, Oddrun; Michelsen, Trond M.; Powell, Theresa L.; Jansson, Thomas

doi:10.1210/clinem/dgab680

Cited by 14 publications

(8 citation statements)

References 67 publications

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“…In addition, other risk factors, including prepregnancy BMI and sedentary behaviour, can be controlled. Previous research, which found that overweight and obese pregnant women had an increased risk of GD, may be attributable to inhibited insulin signalling release 46 . One meta‐analysis pointed out that sedentary behaviour during pregnancy is not clearly associated with GD, perhaps because of reporting differences and measuring challenges, 47 but weight gain resulting from sedentary behaviour and vascular factors is confirmed as being associated with GD.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research, which found that overweight and obese pregnant women had an increased risk of GD, may be attributable to inhibited insulin signalling release. 46 One meta-analysis pointed out that sedentary behaviour during pregnancy is not clearly associated with GD, perhaps because of reporting differences and measuring challenges, 47 but weight gain resulting from sedentary behaviour and vascular factors is confirmed as being associated with GD. Pregnant women should reduce their sedentary time and maintain a low prepregnancy BMI to prevent and reduce the risk of GD.…”

Section: Discussionmentioning

confidence: 99%

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Establishment and validation of a prediction model for gestational diabetes

Wang,

He,

et al. 2023

Diabetes Obesity Metabolism

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AimTo develop a visual prediction model for gestational diabetes (GD) in pregnant women and to establish an effective and practical tool for clinical application.MethodsTo establish a prediction model, the modelling set included 1756 women enrolled in the Zunyi birth cohort, the internal validation set included 1234 enrolled women, and pregnant women in the Wuhan cohort were included in the external validation set. We established a demographic–lifestyle factor model (DLFM) and a demographic–lifestyle–environmental pollution factor model (DLEFM) based on whether the women were exposed to environmental pollutants. The least absolute shrinkage and selection lasso–logistic regression analyses were used to identify the independent predictors of GD and construct a nomogram for predicting its occurrence.ResultsThe DLEFM regression analysis showed that a family history of diabetes (odd ratio [OR] 2.28; 95% confidence interval [CI] 1.05‐4.71), a history of GD in pregnant women (OR 4.22; 95% CI 1.89‐9.41), being overweight or obese before pregnancy (OR 1.71; 95% CI 1.27‐2.29), a history of hypertension (OR 2.61; 95% CI 1.41‐4.72), sedentary time (h/day) (OR 1.16; 95% CI 1.08‐1.24), monobenzyl phthalate (OR 1.95; 95% CI 1.45‐2.67) and Q4 mono‐ethyl phthalate concentration (OR 1.85; 95% CI 1.26‐2.73) were independent predictors. The area under the receiver operating curves for the internal validation of the DLEFM and the DLFM constructed using these seven factors was 0.827 and 0.783, respectively. The calibration curve of the DLEFM was close to the diagonal line. The DLEFM was thus the more optimal model, and the one which we chose.ConclusionsA nomogram based on preconception factors was constructed to predict the occurrence of GD in the second and third trimesters. It provided an effective tool for the early prediction and timely management of GD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Establishment and validation of a prediction model for gestational diabetes

Wang,

He,

et al. 2023

Diabetes Obesity Metabolism

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“…Adiponectin ubiquitination is increased in the visceral fat of obese pregnant women compared to their lean counterparts, and it is a key mechanism through which obesity curtails adiponectin secretion during pregnancy (Table 7 ). 889 …”

Section: Ubiquitinationmentioning

confidence: 99%

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Zhong

Xiao

Xie

et al. 2023

MedComm

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Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent bonds on the backbones or amino acid side chains of proteins and expand the diversity of proteins, which provides the basis for the emergence of organismal complexity. To date, more than 650 types of protein modifications, such as the most well‐known phosphorylation, ubiquitination, glycosylation, methylation, SUMOylation, short‐chain and long‐chain acylation modifications, redox modifications, and irreversible modifications, have been described, and the inventory is still increasing. By changing the protein conformation, localization, activity, stability, charges, and interactions with other biomolecules, PTMs ultimately alter the phenotypes and biological processes of cells. The homeostasis of protein modifications is important to human health. Abnormal PTMs may cause changes in protein properties and loss of protein functions, which are closely related to the occurrence and development of various diseases. In this review, we systematically introduce the characteristics, regulatory mechanisms, and functions of various PTMs in health and diseases. In addition, the therapeutic prospects in various diseases by targeting PTMs and associated regulatory enzymes are also summarized. This work will deepen the understanding of protein modifications in health and diseases and promote the discovery of diagnostic and prognostic markers and drug targets for diseases.

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“…Experiments performed in 3T3L-1 adipocytes showed a potential mechanism whereby ubiquitination of adiponectin in obesity decreases adiponectin in pregnancy [ 127 ]. Ubiquitination and degradation of adiponectin appeared to be prevented by insulin and promoted by inflammation and ER stress, both of which are present in adipose tissue from obese individuals [ 127 ]. Adiponectin secretion and mRNA levels decrease in WAT as pregnancy progresses, in parallel with increasing insulin resistance [ 102 ].…”

Section: Adiponectinmentioning

confidence: 99%

“…Although these results are promising, supplementation in rodent models often utilizes perfusion systems [ 111 ] or hydrodynamic [ 186 ] or viral gene delivery systems [ 132 , 153 ] to maintain circulating adiponectin levels due to rapid turnover of adiponectin in circulation [ 187 ]. Additionally, multiple isoforms of adiponectin exist in different ratios, with varying metabolic activity and post-translational modifications of adiponectin can impact optimal bioactivity, which may differentially impact both maternal and offspring metabolic health outcomes [ 127 ].…”

Section: Adiponectinmentioning

confidence: 99%

The Role of Adiponectin during Pregnancy and Gestational Diabetes

Gruber

Dolinsky

2023

Life

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Pregnancy involves a range of metabolic adaptations to supply adequate energy for fetal growth and development. Gestational diabetes (GDM) is defined as hyperglycemia with first onset during pregnancy. GDM is a recognized risk factor for both pregnancy complications and long-term maternal and offspring risk of cardiometabolic disease development. While pregnancy changes maternal metabolism, GDM can be viewed as a maladaptation by maternal systems to pregnancy, which may include mechanisms such as insufficient insulin secretion, dysregulated hepatic glucose output, mitochondrial dysfunction and lipotoxicity. Adiponectin is an adipose-tissue-derived adipokine that circulates in the body and regulates a diverse range of physiologic mechanisms including energy metabolism and insulin sensitivity. In pregnant women, circulating adiponectin levels decrease correspondingly with insulin sensitivity, and adiponectin levels are low in GDM. In this review, we summarize the current state of knowledge about metabolic adaptations to pregnancy and the role of adiponectin in these processes, with a focus on GDM. Recent studies from rodent model systems have clarified that adiponectin deficiency during pregnancy contributes to GDM development. The upregulation of adiponectin alleviates hyperglycemia in pregnant mice, although much remains to be understood for adiponectin to be utilized clinically for GDM.

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Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity

Cited by 14 publications

References 67 publications

Establishment and validation of a prediction model for gestational diabetes

Establishment and validation of a prediction model for gestational diabetes

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

The Role of Adiponectin during Pregnancy and Gestational Diabetes

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