Insulin-like growth factor 1 receptor expression in breast cancer tissue and mammographic density

Sun, Woo‐Young; Yun, Hyo-Young; Song, Young‐Jin; Kim, Heon; Lee, Ok‐Jun; Nam, Seok‐Jin; Koo, Ja-Seung

doi:10.3892/mco.2015.497

Cited by 20 publications

(9 citation statements)

References 29 publications

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“…Up to now, the prognostic value of the IGF-1R expression on disease outcome has been controversial, with studies reporting both positive and negative findings [16,17,18]. In our study, IGF-1R expression did not independently predict on relapse-free survival and clinical outcome.…”

Section: Discussioncontrasting

confidence: 73%

Immunohistochemical evaluation of insulin-like growth factor receptor 1 in breast cancer

Batinic-Skipina¹,

Marić²,

Tadic-Latinovic

et al. 2018

Srp Arh Celok Lek

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Introduction/Objective Activation of insulin-like growth factor receptor (IGF-1R) results in cell transition from growth phase to synthesis phase of cell cycle. Breast cancer is categorized into prognostic and therapeutic subtypes based upon hormone receptor, estrogen receptor (ER), and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER-2) expression. The objective of this study was to examine the expression of IGF-1R in а specific subtype invasive breast cancer and its correlation with basic histopathological and immunohistochemical prognostic parameters. Methods Formalin-fixed paraffin-embedded tumor samples were obtained from 129 female patients with invasive breast cancer (I-III disease stage) with the follow-up ranging 36-108 months (average 48 months). For immunohistochemical staining, we used monoclonal antibodies for ER, PR, IGF-1R, and polyclonal antibody for HER-2. Results IGF-1R inversely correlated with tumor stage (p = 0.017), tumor grade (p = 0.001), HER-2 (p = 0.003), whereas significant positive correlation was found with multifocality/multicentricity of breast cancer (p = 0.036), ER (p = 0.001) and PR (p = 0.0001) expression. Cox-regression analysis for relapse-free survival (RFS) showed that disease stage (p = 0.039) and HER-2 (p = 0.033) were independent prognostic factors. IGF-1R did not predict clinical outcome in patients with breast cancer (p = 0.488, Kaplan-Meier test for RFS). Conclusion Patients with low stage and grade hormone-dependent breast cancer had a significantly higher IGF-1R expression than patients with triple negative or HER-2 overexpressed cancer. The present findings also highlight that IGF-1R expression in multicentric/multifocal breast cancer supports the key roles in tumor initiation.

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Section: Discussioncontrasting

confidence: 73%

Immunohistochemical evaluation of insulin-like growth factor receptor 1 in breast cancer

Batinic-Skipina¹,

Marić²,

Tadic-Latinovic

et al. 2018

Srp Arh Celok Lek

View full text Add to dashboard Cite

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“…Studies on benign and noninvasive breast lesions, IGF-1R expression was slightly increased in lesions that are hormonally driven (such as atypical ductal hyperplasia and columnar cells changes) and was significantly reduced in ER-negative lesions (such as apocrine metaplasia) which may explain partially lower response rate to neo adjuvant chemotherapy in luminal tumors [22]. IGF-1R expression was associated with mammographic breast tissue density in patients aged >40 y and in premenopausal women, IGF-1R overexpression in breast cancer tissue was significantly associated with HER-2 positivity and poor disease free survival (DFS) [23].…”

Section: Breast Cancermentioning

confidence: 99%

Targeting IGF1R pathway in cancer with microRNAs: How close are we?

2018

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Cancer of the head and neck are the most common cancers in India and account for 30% of all cancers. At molecular level, it could be attributed to the overexpression of growth factors like IGF1-R, EGFR, VEGF-R and deregulation of cell cycle regulators and tumor suppressors. IGF1-R is an emerging target in head and neck cancer treatment, because of its reported role in tumor development, progression and metastasis. IGF1R targeted agents are in advanced stages of clinical development. Nevertheless, these agents suffer from several disadvantages including acquired resistance and toxic side effects. Hence there is a need for developing newer agents targeting not only the receptor but also its downstream signaling. miRNAs are considered as master regulators of gene expression of multiple genes and has been widely reported to be a promising therapeutic strategy. This review discusses the present status of research in both these arenas and emphasizes the role of miRNA as a promising agent for biologic therapy.

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“…In line with research conducted by sun et al that there was no significant correlation between IGFR expression with grade histopathology of carcinoma mammae invasive and IGFR expression with expression of Ki-67. [18] There is a shortage of experimental work on this and weakness that can affect the results of PTEN, IGFR and Ki-67 expression. First, is the technical factor which the techniques that used is partly done manually and the use of a machine did others.…”

Section: Discussionmentioning

confidence: 99%

Correlations Expression PTEN and Expression IGFR with Expression Ki-67 and The Grading Histopathology of Carcinoma Mammae Invasive

Intan¹,

Setiawati²,

Yenita³

et al. 2019

Proceedings of the Proceedings of the 1st EAI International Conference on Medical and Health Research, ICoMHER November 13-14th

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Carcinoma of mammae is a basis of the greatest ferocity that was discovered in of women in the project in an advanced state of and developing countries. Many a gene that has reportedly exchanged in carcinogenesis carcinoma mammae as PTEN, IGFR, Ki-67, Her-2 neu, and p53 are classified as a factor prognostic. It is still a little research report about the expression of PTEN and expression IGFR in the case carcinoma mammae invasive especially in Indonesia. The purpose of this study is to know the relationship between expression PTEN and expression IGFR with Ki-67 expression and grade histopatology of carcinoma mammae invasive. This study took data from

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Insulin-like growth factor 1 receptor expression in breast cancer tissue and mammographic density

Cited by 20 publications

References 29 publications

Immunohistochemical evaluation of insulin-like growth factor receptor 1 in breast cancer

Immunohistochemical evaluation of insulin-like growth factor receptor 1 in breast cancer

Targeting IGF1R pathway in cancer with microRNAs: How close are we?

Correlations Expression PTEN and Expression IGFR with Expression Ki-67 and The Grading Histopathology of Carcinoma Mammae Invasive

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