2014
DOI: 10.1111/exd.12339
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Insulin‐like growth factor‐1: roles in androgenetic alopecia

Abstract: individuals (11). TEWL has been found to be dependent on the skin surface temperature (12), and both rhythms are modified according to the environmental temperature. The circadian variations in these variables could be due to the rhythm of core body temperature and also to modifications in the degree of dilatation of subcutaneous vascular network. This agrees with the fact that the basal TEWL, in humans, reaches their highest levels around 3:00 h (13), corresponding to the peak in skin surface temperature. TEW… Show more

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Cited by 41 publications
(41 citation statements)
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“…Alternatively, investigations are conducted on the topical application of IGF-1, inasmuch as dermal papillary cells from balding scalp follicles have been found to secrete less IGF-1 than their counterparts from nonbalding scalp follicles [25]. Moreover, low circulating IGF-1 levels have been associated with hair loss in middle-aged women [26].…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, investigations are conducted on the topical application of IGF-1, inasmuch as dermal papillary cells from balding scalp follicles have been found to secrete less IGF-1 than their counterparts from nonbalding scalp follicles [25]. Moreover, low circulating IGF-1 levels have been associated with hair loss in middle-aged women [26].…”
Section: Discussionmentioning
confidence: 99%
“…Genetic factors, cytokine imbalance, and oxidative stress can cause abnormal hair follicle cycling and subsequent hair loss (Rho et al, 2005;Aron et al, 2013). Many cytokines and receptors are involved in the cell cycle of human follicle dermal papilla cells, including the vascular endothelial cell growth factor (VEGF) (Shin et al, 2014), vascular endothelial cell growth factor receptor (VEGFR) (Li et al, 2012), fibroblast growth factor (FGF) (Rho et al, 2005), insulin-like growth factor (IGF) (Panchaprateep and Asawanonda, 2014), epidermal growth factor (EGF) (Bressan et al, 2014), keratinocyte growth factor (KGF) (Gopu et al, 2015), and transforming growth factor (TGF) (Kang et al, 2013;Shin et al, 2014). Some hair regeneration has been achieved by molecular effect and growth factors (Danilenko et al, 1996) and follicle dermal stem cells (Rahmani et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…IGF-1 is one of the most extensively studied gene for its essential role in hair cycle control as well as hair shaft differentiation during the development of hair follicles. In its absence, anagen hair follicles in organ culture enter the catagen phase (Panchaprateep and Asawanonda, 2014). DPC from balding scalp follicles were found to secrete significantly less IGF-1 as compared to non-balding scalp follicles (Panchaprateep and Asawanonda, 2014).…”
Section: Discussionmentioning
confidence: 99%
“…In its absence, anagen hair follicles in organ culture enter the catagen phase (Panchaprateep and Asawanonda, 2014). DPC from balding scalp follicles were found to secrete significantly less IGF-1 as compared to non-balding scalp follicles (Panchaprateep and Asawanonda, 2014). This phenomenon was alluded to the prolongation effect of the anagen phase by IGF-1.…”
Section: Discussionmentioning
confidence: 99%