In leading-edge chip designs, the dimensional variation that arises from lithography, etch, and planarization processes of multilevel metallization is significant due to its direct impact on wire parasitics and circuit timing. Modeling the dimensional variation helps reduce uncertainty in the extraction of parasitics and enables closure -not only of design, but of various process-design tradeoffs. Today, interconnect analyses and manufacturing are complicated by several close interactions among various components of the design and manufacturing flows. Our research program explores many of these previously-ignored, cross-domain interactions for multilevel interconnect, including those between lithography, topography, dummy fill, and circuit performance. Studies described in this paper include wire CD control through topography-aware OPC; accurate parasitic extraction by modeling wire sidewall angle and dummy fill; and timing-driven, intelligent CMP fill synthesis.