Integrated ionic liquid-based electrofluidic circuits for pressure sensing within polydimethylsiloxane microfluidic systems

Wu, Chueh‐Yu; Liao, Wei-Hao; Tung, Yi-Chung

doi:10.1039/c0lc00620c

Cited by 106 publications

(99 citation statements)

References 34 publications

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“…6,[13][14][15][16][17] have used the elastic nature of PDMS as a tool to relate the channel pressure from the deflection of the PDMS wall by using imaging tools such as microscopes. However, these methods often require multiple fabrication steps 14 to incorporate additional channel layers onto the main PDMS flow channel, 6,13,15,16 fluorescent particles, 6,17 or even introduce separate probing fluids. 13,15 In order to afford the flexibility of measuring pressure drops in existing PDMS microdevices with minimal alterations, a straightforward and repeatable method is necessary.…”

Section: Introductionmentioning

confidence: 99%

In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices

2012

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In this paper, we present a simple procedure to incorporate commercially available external pressure transducers into existing microfluidic devices, to monitor pressure-drop in real-time, with minimal design modifications to pre-existing channel designs. We focus on the detailed fabrication steps and assembly to make the process straightforward and robust. The work presented here will benefit those interested in adding pressure drop measurements in polydimethylsiloxane (PDMS) based microchannels without having to modify existing channel designs or requiring additional fabrication steps. By using three different devices with varying aspect ratio channels (wh0, width/depth), we demonstrate that our approach can easily be adapted into existing channel designs inexpensively. Furthermore, our approach can achieve steady state measurements within a matter of minutes (depending on the fluid) and can easily be used to investigate dynamic pressure drops. In order to validate the accuracy of the measured pressure drops within the three different aspect ratio devices, we compared measured pressure drops of de-ionized water and a 50 wt. % glycerol aqueous solution to four different theoretical expressions. Due to the deformability of PDMS, measured pressure drops were smaller than those predicted by the rigid channel theories (plate and rectangular). Modification of the rigid channel theories with a deformability parameter α provided better fits to the measured data. The elastic rectangular expression developed in this paper does not have a geometric restriction and is better suited for microchannels with a wider range of aspect ratios.

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Section: Introductionmentioning

confidence: 99%

In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices

2012

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“…10 Wu et al developed a two-layer on-chip pressure sensor using a deformable PDMS membrane with ionized fluid. 9 The same sensor is later applied to a study of endothelia cells by Liu et al 11 Some other approaches utilize vision-based information for pressure estimation. 12 For example, Srivastava and Burns determined microfluidic pressure using the amount of trapped air compression.…”

Section: Related Workmentioning

confidence: 99%

“…The deformation chamber is a wide chamber with a large surface area, which softens the structural stiffness of the chamber, and makes it easy to deform. 8,9 The chamber is connected to the point of interest by a probe channel as indicated in the top view. The other concentric chamber, the sensing chamber, is located inside the deformation chamber.…”

Section: Introductionmentioning

confidence: 99%

On-chip pressure sensor using single-layer concentric chambers

Tsai

Kaneko

2016

Biomicrofluidics

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A vision-based on-chip sensor for sensing local pressure inside a microfluidic device is proposed and evaluated in this paper. The local pressure is determined from the change of color intensity in the sensing chamber which is pre-filled with colored fluid. The working principle of the sensor is based on polydimethylsiloxane deformation. The pressure at the point of interest is guided into a deformation chamber, where the structural stiffness is softened by chamber geometry, and thus, the chamber deforms as a result of pressure changes. Such deformation is transmitted to the sensing chamber, a same-layer concentric inside the deformation chamber. The deformation in the sensing chamber causes the colored fluid flowing in or out the chamber and leads to different color intensity from the top view through a microscope. Experimental evaluations on static and dynamic responses by regulated input pressures were conducted. The correlation in static response is 0.97 while the dynamic responses are successfully observed up to 16 Hz. The greatest advantage is that the local pressure can be directly seen without any additional hardware or electricity. The whole sensor is on a single-layer microfluidic design, so that the fabrication is simple, consistent, and low-cost. The single-layer design also provides the convenience of easy integration for existing microfluidic systems.

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“…We suspected that this discrepancy was due to the deformation of the curved channel under the pumped flow. 16 …”

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confidence: 99%

Effects of hydraulic pressure on cardiomyoblasts in a microfluidic device

et al. 2015

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We employed a microfluidic device to study the effects of hydraulic pressure on cardiomyoblast H9c2. The 170 mm Hg pressure increased the cellular area and the expression of atrial natriuretic peptide. With the same device, we demonstrated that the effects of hydraulic pressure on the cardiomyoblast could be reduced by the inhibitor of focal adhesion kinase. This mechanical-chemical antagonism could lead to a potential therapeutic strategy of hypertension-induced cardiac hypertrophy. V C 2015 AIP Publishing LLC. [http://dx

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Integrated ionic liquid-based electrofluidic circuits for pressure sensing within polydimethylsiloxane microfluidic systems

Cited by 106 publications

References 34 publications

In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices

In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices

On-chip pressure sensor using single-layer concentric chambers

Effects of hydraulic pressure on cardiomyoblasts in a microfluidic device

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