Integrated <sup>18</sup>F‐FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast‐enhanced CT

Jeong, Han‐Sin; Baek, Chung‐Hwan; Son, Younggon; Choi, Ju Young; Kim, Hyungjin; Ko, Young‐Hyeh; Chung, Jae-Hoon; Baek, Hye Jin

doi:10.1111/j.1365-2265.2006.02612.x

Cited by 151 publications

(105 citation statements)

References 29 publications

(87 reference statements)

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“…Three previous studies have evaluated the diagnostic accuracy of FDG PET in N staging of thyroid cancer (Table 1; Jeong et al 2006a, Morita et al 2010, Choi et al 2011b. LN metastases of thyroid cancer are found most commonly in the central neck compartment (Ferris et al 2012).…”

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

“…The overall diagnostic accuracy tended to be higher for lateral LNs than for central LNs. Jeong et al (2006a) reported that 5% (1/20) of the metastatic LNs in the central compartment were detected by PET. PET did not prove to be superior to US or CT (Jeong et al 2006a, Choi et al 2011b.…”

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

“…Jeong et al (2006a) reported that 5% (1/20) of the metastatic LNs in the central compartment were detected by PET. PET did not prove to be superior to US or CT (Jeong et al 2006a, Choi et al 2011b. US imaging may thus be the best methodology for preoperative assessment since it yielded results superior to those of either PET or CT alone for the detection of LN metastasis (Morita et al 2010).…”

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

See 2 more Smart Citations

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

Pak¹,

Kim²,

Kim³

et al. 2013

Endocrine-Related Cancer

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The incidence of thyroid cancer in both men and women is increasing faster than that of any other cancer. Although positron emission tomography (PET) using 18 F-fluorodeoxyglucose (FDG) has received much attention, the use of FDG PET for the management of thyroid cancer is limited primarily to postoperative follow-up. However, it might have a role in selected, more aggressive pathologies, and so patients at a high risk of distant metastasis may benefit from PET before surgery. As less FDG-avid thyroid cancers may lower the diagnostic accuracy of PET in preoperative assessment, an understanding of FDG avidity is important for the evaluation of thyroid cancer. FDG avidity has been shown to be associated with tumor size, lymph node metastasis, and glucose transporter expression and differentiation. As PET is commonly used in clinical practice, the detection of incidentalomas by PET is increasing. However, incidentalomas detected by PET have a high risk of malignancy. Clinicians handling cytologically indeterminate nodules face a dilemma regarding a procedure for a definitive diagnosis, usually lobectomy. With 'nondiagnostic (ND)' fine-needle biopsy (FNA), PET has shown a negative predictive value (NPV) of 100%, which indicates that negative uptake in a ND FNA procedure accurately excludes malignancy. With 'atypia of undetermined significance' or 'follicular neoplasm', the sensitivity and NPV of PET are 84 and 88%. PET does not provide additional information for the preoperative assessment of thyroid cancer. However, factors associated with FDG positivity are related to a poor prognosis; therefore, FDG PET scans before surgery may facilitate the prediction of the prognosis of differentiated thyroid cancer.

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Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

Section: Preoperative Assessment Of Thyroid Cancer With Fdg Petmentioning

confidence: 99%

See 1 more Smart Citation

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

Pak¹,

Kim²,

Kim³

et al. 2013

Endocrine-Related Cancer

View full text Add to dashboard Cite

show abstract

“…This is usually carried out by preoperative USG of the regional neck lymph nodes in the central and lateral neck compartments. Jeong et al [45] compared the diagnostic accuracy of FDG-PET/CT as a novel staging alternative to USG for the preoperative evaluation of cervical lymph node status in patients with PTC. The final cervical lymph node status was confirmed by histopathology.…”

Section: Role Of Fdg-pet In Patients With Primary Dtcmentioning

confidence: 99%

The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms

Lang

Law

2011

The Oncologist

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“…The present study found that the majority of disease that was detected on a PET scan was in the cervical and mediastinal lymph nodes. In the preoperative setting, ultrasound has a higher sensitivity to detect abnormal cervical lymph nodes than PET/CT (25). Given the increased cost and radiation exposure of PET/CT compared with ultrasound, its use should be reserved for indications for which there is strong evidence supporting its utility.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Positron Emission Tomography Use in Differentiated Thyroid Cancer

Wiebel

Esfandiari

Papaleontiou

et al. 2015

Thyroid

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Background: Using the Surveillance, Epidemiology, and End Results-Medicare database, a substantial increase was found in the use of positron emission tomography (PET) scans after 2004 in differentiated thyroid cancer (DTC) patients. The reason for the increased utilization of the PET scan was not clear based on available the data. Therefore, the indications for and outcomes of PET scans performed at an academic institution were evaluated. Methods: A retrospective cohort study was performed of DTC patients who underwent surgery at the University of Michigan Health System from 2006 to 2011. After identifying patients who underwent a PET scan, indications, rate of positive PET scans, and impact on management were evaluated. For positive scans, the location of disease was characterized, and presence of disease on other imaging was determined. Results: Of the 585 patients in the cohort, 111 (19%) patients had 200 PET scans performed for evaluation of DTC. Indications for PET scan included: elevated thyroglobulin and negative radioiodine scan in 52 scans (26.0%), thyroglobulin antibodies in 13 scans (6.5%), rising thyroglobulin in 18 scans (9.0%), evaluation of abnormality on other imaging in 22 scans (11.0%), evaluation of extent of disease in 33 scans (16.5%), followup of previous scan in 57 scans (28.5%), other indications in two scans (1.0%), and unclear indications in three scans (1.5%). The PET scan was positive in 124 studies (62.0%); positivity was identified in the thyroid bed on 25 scans, cervical or mediastinal lymph nodes on 105 scans, lung on 28 scans, bone on four scans, and other areas on 14 scans. Therapy following PET scan was surgery in 66 cases (33.0%), chemotherapy or radiation in 23 cases (11.5%), observation in 110 cases (55.0%), and palliative care in one case (0.5%). Disease was identifiable on other imaging in 66% of cases. PET scan results changed management in 59 cases (29.5%). Conclusions: In this academic medical center, the PET scan was utilized in 19% of patients. Indications for the PET scan included conventional indications, such as elevated thyroglobulin with noniodine avid disease, and more controversial uses, such as evaluation of extent of disease or abnormalities on other imaging tests. PET scan results changed management in about 30% of cases.

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Integrated ¹⁸F‐FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast‐enhanced CT

Abstract: Our preliminary results suggest that integrated PET/CT does not provide any additional benefit when compared to US and CECT for the initial evaluation of cervical node levels in patients with papillary thyroid carcinoma.

Cited by 151 publications

References 29 publications

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms

Evaluating Positron Emission Tomography Use in Differentiated Thyroid Cancer

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Integrated 18F‐FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast‐enhanced CT

Abstract: Our preliminary results suggest that integrated PET/CT does not provide any additional benefit when compared to US and CECT for the initial evaluation of cervical node levels in patients with papillary thyroid carcinoma.

Cited by 151 publications

References 29 publications

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

The role of 18F-fluorodeoxyglucose positron emission tomography in differentiated thyroid cancer before surgery

The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Thyroid Neoplasms

Evaluating Positron Emission Tomography Use in Differentiated Thyroid Cancer

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Product

Resources

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Integrated ¹⁸F‐FDG PET/CT for the initial evaluation of cervical node level of patients with papillary thyroid carcinoma: comparison with ultrasound and contrast‐enhanced CT