Integrating static and dynamic features of melanoma: The DynaMel algorithm

Buhl, Timo; Hansen-Hagge, Christian; Korpas, Bianca; Kaune, Kjell M.; Haas, E; Rosenberger, Albert; Schön, Michael P.; Emmert, Steffen; Haenssle, Holger A.

doi:10.1016/j.jaad.2010.09.731

Cited by 22 publications

(28 citation statements)

References 31 publications

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“…Recent studies on DFU have shown some particular changes as being significantly associated to melanoma. Particularly, the presence of focal changes in colour and structure were more frequent in melanoma . In our series focal change in structure was significantly associated to melanoma, however, this was not the case of focal change in pigmentation.…”

Section: Discussionsupporting

confidence: 92%

In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

Lovatto

Carrera

Salerni

et al. 2015

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 92%

In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

Lovatto

Carrera

Salerni

et al. 2015

Acad Dermatol Venereol

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“…In their study melanomas (n = 8) often demonstrated focal growth in association with changes of the form and the lesional architecture, while most benign nevi showed symmetric growth often with a rim of brown globules at the periphery. In a recently published retrospective study, these results could be confi rmed and expanded in a larger series of excised lesions with dynamic alterations during the course (n = 675, of these 61 melanomas) with a comprehensive statistical analysis [ 24 ] . Thus, asymmetric-multifocal growth, a newly developed architectural alteration (particularly signs of regression), a focal alteration of pigmentation (in-or decrease) as well as an extensive decrease of pigmentation were signifi cantly associated with the diagnosis of melanoma [ 24 ] .…”

Section: Criteria For Well-founded Decisions For Excisionmentioning

confidence: 76%

“…In a recently published retrospective study, these results could be confi rmed and expanded in a larger series of excised lesions with dynamic alterations during the course (n = 675, of these 61 melanomas) with a comprehensive statistical analysis [ 24 ] . Thus, asymmetric-multifocal growth, a newly developed architectural alteration (particularly signs of regression), a focal alteration of pigmentation (in-or decrease) as well as an extensive decrease of pigmentation were signifi cantly associated with the diagnosis of melanoma [ 24 ] . On the other hand, in this study as well as in the paper by Kittler et al, symmetric growth of the lesion, the appearance of a complete rim of globuli at the periphery and an increase of pigmentation over the entire pigmented nevus was more often associated with benign than with malignant lesions and should thus not regularly lead to excision (Figure 3 a-d).…”

Section: Criteria For Well-founded Decisions For Excisionmentioning

confidence: 76%

Early detection of cutaneous melanoma by sequential digital dermatoscopy (SDD)

Kraus

Haenssle

2013

J Deutsche Derma Gesell

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SummaryThe early diagnosis and excision of cutaneous melanoma is essential for an improved prognosis of the disease. Besides the investigation of pigmented lesions with the unaided eye and conventional dermatoscopy, long-term sequential digital dermatoscopy has been shown to improve the sensitivity of melanoma detection, especially in highrisk patients. In addition to the static clinical and dermatoscopic assessment, the sequential digital dermatoscopy strategy helps to detect changes over time. This review summarizes the latest developments in the field of sequential digital dermatoscopy, describes current strategies for the selection of patients and lesions to monitor, and suggests objective criteria that should lead to an excisional biopsy. Sophie Luise Kraus , Holger Andreas HaenssleUniversity Medical Center Göttingen , Department of Dermatology, Allergology and Venereology , Göttingen , Germany Early detection of cutaneous melanoma by sequential digital dermatoscopyThe prognosis of cutaneous melanoma, an aggressive and potentially life-shortening melanocytic tumor, primarily depends on early recognition and prompt excision of the tumor. A smaller tumor thickness (Breslow depth) at excision is associated with a better prognosis [ 1 ] . Two meta-analyses have demonstrated that dermatoscopy (synonym: epiluminescence microscopy) can signifi cantly improve the sensitivity for recognition of cutaneous melanomas in comparison to examination with the naked eye [ 2,3 ] . Melanoma-associated dermatoscopic features were fi rst described in the pattern analysis [ 4 ] , later expanded by additional criteria and summarized in numerous diagnostic algorithms (e.g. 7-point checklist) [ 5,6 ] .Occasionally cutaneous melanoma can lack characteristic features, especially in very early or very advanced stages [ 7 ] , so that the diagnosis is made more diffi cult and additional information appears desirable for assessment. Sequential digital dermatoscopy (SDD) by imaging in defi ned time intervals provides information on the dynamic changes of pigmented lesions. Certain morphologic alterations, such as asymmetric growth, already point to the presence of an initial cutaneous melanoma, even though further melanoma-typical dermatoscopic or clinical criteria are not yet fulfi lled [8][9][10] .It is sensible to differentiate between two strategies of sequential digital dermatoscopy. Short-term follow-up involves one-time control of an individual lesion with higher-grade atypia after maximally three months; an excision should be performed in the event of any dynamic alterations [ 11,12 ] . Long-term follow-up serves to optimize monitoring of patients at risk [13][14][15] . Here longer examinations intervals of up to 12 months are employed and a larger number of atypical nevi are included in the observation. Optimally, sequential digital dermatoscopy of patients at high risk is supplemented by total body photography, that means overview images of all body regions, to detect newly developed pigmented lesion [ 9,16 ] .Risk factors for th...

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“…Melanome (n = 8) zeigten in dieser Studie häufi g ein fokales Wachstum in Assoziation mit Veränderungen der Form und der läsionalen Architektur, während die meisten benignen Nävi ein symmetrisches Wachstum oft mit randständigen braunen Globuli aufwiesen. In einer vor kurzem publizierten retrospektiven Studie konnten diese Ergebnisse anhand einer größeren Serie exzidierter Läsionen mit dynamischen Verlaufsveränderun-gen (n = 675, davon 61 Melanome) und einer ausführlichen statistischen Analyse bestätigt und erweitert werden [24]. So waren ein asymmetrisch-multifokales Wachstum, eine neu aufgetretene architekturelle Veränderung (insbesondere Zeichen der Regression), eine fokale Veränderung der Pigmentierung (Zu-oder Abnahme) sowie eine fl ächenhafte Abnahme der Pigmentierung signifi kant mit der Diagnose eines malignen Melanoms assoziiert [24].…”

Section: Kriterien Für Fundierte Exzisionsentscheidungenunclassified

Früherkennung kutaner Melanome mittels sequentieller digitaler Dermatoskopie (SDD)

Kraus

Haenssle

2013

J Deutsche Derma Gesell

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Integrating static and dynamic features of melanoma: The DynaMel algorithm

Cited by 22 publications

References 31 publications

In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

In vivo reflectance confocal microscopy of equivocal melanocytic lesions detected by digital dermoscopy follow‐up

Early detection of cutaneous melanoma by sequential digital dermatoscopy (SDD)

Früherkennung kutaner Melanome mittels sequentieller digitaler Dermatoskopie (SDD)

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