Interaction of Povidone with Aromatic Compounds III: Thermodynamics of the Binding Equilibria and Interaction Forces in Buffer Solutions at Varying pH Values and Varying Dielectric Constant

Complexation of fluoroquinolone antibiotics with human serum albumin: A fluorescence quenching study

“…In the case of levofloxacin, hydrogen bonding interactions are predominantly involved since there is a major contribution of enthalpy term (large negative enthalpy change) to the free energy change [20]. Negative DS 0 value is associated with an additional contribution of Van der Waals interactions [21]. There is about equal contribution of enthalpy and entropy terms and therefore, hydrogen bonding as well as hydrophobic interactions is involved in the binding of sparfloxacin to HSA [22].…”

“…On the basis of the sign and magnitude of thermodynamic parameters and the relative contribution of enthalpy and entropy terms to standard free energy change, the nature of interaction could be predicted [20][21][22]. In the case of levofloxacin, hydrogen bonding interactions are predominantly involved since there is a major contribution of enthalpy term (large negative enthalpy change) to the free energy change [20].…”

Synthesis of a novel 4H-pyran analog as minor groove binder to DNA using ethidium bromide as fluorescence probe

“…hydrogen bonding and Van der Waals interactions are involved in the binding [41]. The negative value of DG suggests that the binding between 4H-pyran analog and hs DNA occurred spontaneously.…”

Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier

“…Studies of the interactions between PVP and drugs have been published for diverse other formulations [11][12][13] . These studies were more focused on evaluation of the drug release properties from the microreservoirs rather than on thermodynamics and physico-chemical properties of such type of TDDS 9,[14][15][16] .…”