2008
DOI: 10.1016/j.aca.2008.04.043
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Interferences and contaminants encountered in modern mass spectrometry

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Cited by 548 publications
(487 citation statements)
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References 79 publications
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“…It is hardly feasible to transmit ions below 100 Da efficiently into the ICR cell by tuning instrument parameters. Some peaks with higher m/z values differ by 44.0263 Da, which corresponds to C 2 H 4 O, indicating that these peaks may represent polyethylene glycol (with an increasing number of monomers) which is a common contaminant in ESI 37,38 . Different Kendrick plots were obtained from ESI and APCI experiments (Figure 1) since different species tend to ionize with these techniques, and these results will be discussed in detail below.…”
Section: Resultsmentioning
confidence: 99%
“…It is hardly feasible to transmit ions below 100 Da efficiently into the ICR cell by tuning instrument parameters. Some peaks with higher m/z values differ by 44.0263 Da, which corresponds to C 2 H 4 O, indicating that these peaks may represent polyethylene glycol (with an increasing number of monomers) which is a common contaminant in ESI 37,38 . Different Kendrick plots were obtained from ESI and APCI experiments (Figure 1) since different species tend to ionize with these techniques, and these results will be discussed in detail below.…”
Section: Resultsmentioning
confidence: 99%
“…External calibration was performed based on monoisotopic values of well-defined peptides. Obtained mass spectra were corrected for matrix-and enzymederived interferences (Keller et al, 2008). The resulting monoisotopic list of m/z values was submitted to the search engine MASCOT (Perkins et al, 1999) searching all proteins and DNA sequence information from public databases (MSDB, Swiss-Prot, NCBInr) and the translated partial genome sequence information from Parachlamydia acanthamoebae UV7 and Acanthamoeba castellanii containing 2931 Parachlamydia sequences and 12 990 sequences of Acanthamoeba.…”
Section: Mass Spectrometrymentioning
confidence: 99%
“…4A Minnikin et al (2010) that the sequences of peaks in Fig. 4 are characteristic of contaminating polymers based on polyethylene glycol (PEG) (Keller et al, 2008;Schiller et al, 2004) is a much more plausible explanation. The proposal by Mark et al (2011) is that an authentic MALDI-TOF spectrum (Fig.…”
Section: Mass Spectrometry In Detection Of Mycolic Acid Biomarkers Fomentioning
confidence: 99%
“…As suggested previously , an alternative explanation for the regular 44 amu spacing of the components is that the peaks are derived from a material incorporating polyethylene glycol repeating units. These polymeric polyethylene glycol-based preparations are in widespread industrial use and the risk of their appearance in mass spectra is well-known, as emphasized by, for example, by Keller et al (2008) and Schiller et al (2004), the latter reproducing a representative MALDI-TOF mass spectrum. Another general point, which comprehensively disqualifies the profiles in Figs.…”
Section: Mass Spectrometry In Detection Of Mycolic Acid Biomarkers Fomentioning
confidence: 99%