2008
DOI: 10.1002/art.23291
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Interleukin‐17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers

Abstract: Objective. To identify interleukin-17 (IL-17Conclusion. This study is the first to define the frequency and characteristics of "Th17" cells in JIA. We suggest that these highly proinflammatory cells contribute to joint pathology, as indicated by relationships with clinical phenotypes, and that the balance between IL-17؉

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Cited by 301 publications
(271 citation statements)
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“…Therefore, it is very conceivable that the low levels of IL-17 detected in the present study are biologically relevant in an inflamed milieu. The frequencies of Th17 cells reported herein are also consistent with the frequencies of IL-17-positive cells reported by others (18,19,34,35). The tight association of Th17 cell frequencies with RA disease activity at the onset of disease ( Figure 1) and in established RA (Figure 3) clearly points toward a role for this T cell subset in the pathophysiology of the disease.…”
Section: Discussionsupporting
confidence: 90%
“…Therefore, it is very conceivable that the low levels of IL-17 detected in the present study are biologically relevant in an inflamed milieu. The frequencies of Th17 cells reported herein are also consistent with the frequencies of IL-17-positive cells reported by others (18,19,34,35). The tight association of Th17 cell frequencies with RA disease activity at the onset of disease ( Figure 1) and in established RA (Figure 3) clearly points toward a role for this T cell subset in the pathophysiology of the disease.…”
Section: Discussionsupporting
confidence: 90%
“…IL-17 may also contribute directly to joint damage, because it was shown to act synergistically with TNF-␣ and/or IL-1␤ to induce cartilage destruction in vitro and in experimental arthritis in vivo (17)(18)(19). In RA, SM IL-17 expression in synergy with TNF-␣ is predictive of joint damage progression (20), and, in juvenile idiopathic arthritis (JIA), the number of IL-17-expressing T cells is higher in patients with the more severe form of disease (21). Despite these data, very little is known about what drives human Th17 responses in vivo, particularly at sites of inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…[107][108][109][110] Considering the central role of Th17 cells in autoimmune diseases including rheumatoid arthritis (RA) and psoriasis, mutations in inflammasome-encoding genes may result in a broad spectrum of Th17 cell-mediated autoimmune disorders, through deregulation of IL-1b secretion. 107,[111][112][113][114][115][116] Genetic variants in several inflammatory genes, including NLRP3, are associated with two forms of autoimmune arthritis: juvenile idiopathic arthritis and RA, characterized by Th17 cells. 117,118 Indeed, increased expression of NLRP3 was observed in the synovium of RA patients compared to subjects suffering from non-autoimmune osteoarthritis.…”
Section: Adaptive Immunity-mediated Diseasesmentioning
confidence: 99%