Intestinal anti-inflammatory activity of the seeds of Raphanus sativus L. in experimental ulcerative colitis models

Choi, Ki-Seok; Cho, Seong-Wan; Kook, Sung‐Ho; Chun, Sa-Ra; Bhattarai, Govinda; Poudel, Sher Bahadur; Kim, Min-Kook; Lee, Kyung-Yeol; Lee, Jeong-Chae

doi:10.1016/j.jep.2015.12.045

Cited by 27 publications

(14 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Leaves of white radish are known to have anti-inflammatory activity in lipopolysaccharidestimulated macropahages via nuclear factor-kappa B inactivation (Park and Song 2017). Water extracts of white radish seeds have been used in traditional medicine to treat digestive inflammation, diarrhea, and abdomen illness in East Asia (Kim et al 2015;Choi et al 2016). Therefore, WRB has high potential as an alternative source for MA in abalone feed.…”

Section: Introductionmentioning

confidence: 99%

Substitution effect of white radish (Raphanus sativus L.)’ by-product and tunic of sea squirt (Halocynthia rorentzi, von Drasche) for Undaria pinnatifida in feed of abalone (Haliotis discus, Reeve 1846)

Lee

Kim

et al. 2018

Fish Aquatic Sci

View full text Add to dashboard Cite

Substitution effect of white radish' by-product (WRB) and tunic of sea squirt (TSS) for Undaria in feed on growth and carcass composition of abalone was determined. Eight-hundred forty juveniles were distributed into 12 containers. Three formulated diets were prepared in triplicate. A 15% Undaria was included in the control diet. The 15% Undaria was substituted with a same amount of WRB and TSS, referred to as the DRG and TSS diets, respectively. Finally, dry Undaria was also prepared to compare effect of the formulated diets on performance of abalone. The experimental diets were fed to abalone once a day at a satiation level with a little leftover. The feeding trial lasted for 16 weeks. Crude protein, crude lipid, and ash content of the experimental diets changed over all period of time. Higher crude protein and lipid and ash contents retained in all formulated diets compared to the Undaria were observed at 24 and 48 h after seawater immersion. Survival of abalone was not affected by the experimental diets. Weight gain and specific growth rate (SGR) of abalone fed the TSS diet was greater than all other diets. Weight gain and SGR of abalone fed the control diet was not different from those of abalone fed the WRB diet. Proximates of the soft body of abalone was affected by the diets. In conclusion, WRB and TSS are the promising feed ingredients to replace Undaria in abalone feed; especially, TSS is superior to either Undaria or WRB. The formulated diets produced improved growth performance of abalone over the single Undaria.

show abstract

Section: Introductionmentioning

confidence: 99%

Substitution effect of white radish (Raphanus sativus L.)’ by-product and tunic of sea squirt (Halocynthia rorentzi, von Drasche) for Undaria pinnatifida in feed of abalone (Haliotis discus, Reeve 1846)

Lee

Kim

et al. 2018

Fish Aquatic Sci

View full text Add to dashboard Cite

show abstract

“…Its root and leaves are the main materials for the traditional Korean food, kimchi. RS has been used in traditional medicine to treat digestive related diseases such as indigestion, digestive inflammation, diarrhea, and abdomen illness in East Asia (9). Its extracts are known to show an inhibitory effect on tumor growth.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, they inhibited metastasis in melanoma cells (12). Recently, several studies reported that the seeds of RS showed anti-inflammatory effects (9,13,14). However, no studies investigated the anti-inflammatory activity of the leaves of RS (RSL).…”

Section: Introductionmentioning

confidence: 99%

Leaves of Raphanus sativus L. Shows Anti-Inflammatory Activity in LPS-Stimulated Macrophages via Suppression of COX-2 and iNOS Expression.

Park

Song

2017

JFN

View full text Add to dashboard Cite

Raphanus sativus L. (RS) is a cruciferous vegetable that is widely consumed in Korea. The anticancer activity of leaves of RS (RSL) extract has been investigated; however, no studies focused on its anti-inflammatory effects. Therefore, the aim of the current study was to evaluate the anti-inflammatory effects of RSL extract. In brief, RSL powder was fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and water-soluble fractions. Lipopolysaccharide (LPS)-stimulated RAW264.7 cells were treated with each fraction for initial screening. It was found that the chloroform fraction significantly inhibited nitric oxide release in LPS-stimulated RAW264.7 cells with a half maximal inhibitory concentration value of 196 μg/mL. In addition, the mRNA and protein expression levels of inducible nitric oxide synthase, measured using reverse transcriptase-polymerase chain reaction and western blotting, respectively, were reduced in a concentration-dependent manner. Moreover, the inflammatory cyclooxygenase-2 enzyme expression decreased. Furthermore, the expression of nuclear factor-kappa B (NF-κB), the key regulator of the transcriptional activation of the inflammatory cytokine genes, was reduced by the RSL chloroform fraction. Therefore, the results of our study suggest that RSL exhibits anti-inflammatory effects in LPS-stimulated macrophages via NF-κB inactivation.

show abstract

“…9 In addition, different parts of this plant, such as the roots, leaves, and seeds, can be used in culinary and traditional medicine treatments to digestive inflammation and diarrhea in East Asia. 10 Radish greens (also known as Mucheong) and roots contain carbohydrates, sugars, protein, various dietary fibers, vitamins, and minerals. 11 Moreover, they contain several phenolic compounds, such as ferulic, hydroxycinnamic, vanillic, salicylic, caffeic, and gentisic acids and glucosinolates (benzyl isothiocyanate).…”

Section: Introductionmentioning

confidence: 99%

A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes

Lee

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Intestinal anti-inflammatory activity of the seeds of Raphanus sativus L. in experimental ulcerative colitis models

Cited by 27 publications

References 40 publications

Substitution effect of white radish (Raphanus sativus L.)’ by-product and tunic of sea squirt (Halocynthia rorentzi, von Drasche) for Undaria pinnatifida in feed of abalone (Haliotis discus, Reeve 1846)

Substitution effect of white radish (Raphanus sativus L.)’ by-product and tunic of sea squirt (Halocynthia rorentzi, von Drasche) for Undaria pinnatifida in feed of abalone (Haliotis discus, Reeve 1846)

Leaves of Raphanus sativus L. Shows Anti-Inflammatory Activity in LPS-Stimulated Macrophages via Suppression of COX-2 and iNOS Expression.

A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes

Contact Info

Product

Resources

About