2018
DOI: 10.1177/1947603518796550
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Intra-Articular Delivery of Quercetin Using Thermosensitive Hydrogel Attenuate Cartilage Degradation in an Osteoarthritis Rat Model

Abstract: Objective Quercetin (Que), a bioflavonoid, is both anti-inflammatory and antioxidative. Que has been used as an oral supplement for osteoarthritis (OA) with inconsistent findings because of its low bioavailability. We encapsulated Que in a mPEG-polypeptide thermogel to prolong its bioactivity. The efficacy of this formulation was evaluated in a posttraumatic OA rat model. Design Methoxy-poly(ethylene glycol)-l-poly(alanine) (mPEG-PA) polymer was synthesized and characterized in terms of cytotoxicity and releas… Show more

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Cited by 47 publications
(31 citation statements)
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“…The findings of lower maximum force and shorter stance time on the operated knee at the 4-week timepoint in all groups are consistent with those previously reported in rodent models of PTOA over 6 weeks, where prolonged swing phase, slower swing velocity, and loading asymmetry were observed. 11,13,22 An ovine model of bilateral medial menisectomy also documented decreased ground-reaction forces at 6 weeks after surgery persisting over a duration of 20 weeks. 5 Using a longitudinal experimental design to evaluate knee joint kinematics, we were able to longitudinally assess gait asymmetries in the porcine model of PTOA over a 1-year period after injury.…”
Section: Discussionmentioning
confidence: 97%
“…The findings of lower maximum force and shorter stance time on the operated knee at the 4-week timepoint in all groups are consistent with those previously reported in rodent models of PTOA over 6 weeks, where prolonged swing phase, slower swing velocity, and loading asymmetry were observed. 11,13,22 An ovine model of bilateral medial menisectomy also documented decreased ground-reaction forces at 6 weeks after surgery persisting over a duration of 20 weeks. 5 Using a longitudinal experimental design to evaluate knee joint kinematics, we were able to longitudinally assess gait asymmetries in the porcine model of PTOA over a 1-year period after injury.…”
Section: Discussionmentioning
confidence: 97%
“…The MET release model is similar to the TSG-6 release of heparin microparticles (Tellier et al, 2018). The MET release model is similar to the Quercetin release of a thermosensitive hydrogel in Mok et al (2018).…”
Section: Drug Deliverymentioning
confidence: 58%
“…The MET release model is similar to the TSG‐6 release of heparin microparticles (Tellier et al, 2018). The MET release model is similar to the Quercetin release of a thermosensitive hydrogel in Mok et al (2018). In a study by Ren et al in 2018, it was found that the release of hydroxyapatite and calcium carbonate from OA/CMC hydrogel was accomplished at 60% after 21 days (Ren et al, 2018).…”
Section: Resultsmentioning
confidence: 76%
“…Intra-articular therapy provides a direct route of drug administration to a diseased joint and has many advantages, including increased bioavailability and minimized potential systemic side effects. A thermo-sensitive, biodegradable in situ-forming HG, containing Q and formed by a methoxy-PEG- l -poly(alanine) (mPEG-PA) polymer, was shown to be able to reduce cartilage degradation in rats which had undergone anterior cruciate ligament transection [ 48 ].…”
Section: Potential Biomedical Applications Of (Poly)phenols Loadedmentioning
confidence: 99%
“…A thermo-sensitive HG for the intra-articular delivery of Q was developed by Mok S.-W. et al [ 48 ], as this flavonoid showed in vitro chondroprotective properties and anti-apoptotic effects on arthritic fibroblast-like synoviocytes [ 91 , 92 ]. This injectable system was composed of a polypeptide, i.e., l -poly(alanine) (PA), functionalized with methoxy-PEG (mPEG) and was synthesized by ring-opening polymerization of N -carboxy anhydride of l -alanine on α-methoxy-ε-amino PEG.…”
Section: Injectable Hydrogelsmentioning
confidence: 99%