Intravascular coagulation in obstetrics: Serial dilution protamine sulfate test throughout labor

Piñango, Carmen Luisa Arocha; Linares, J.; Cova, Armando; Martínez, P.I. Barrera; Montilla, Gonzalo Pradas; Rodríguez, S.

doi:10.1016/0002-9378(76)90004-1

Cited by 5 publications

(2 citation statements)

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“…With resepct to labour, Kleiner (1970) seems to have been the first to define the existence of a reversible intravascular coagulation during this period. This has been confirmed by Arocha Pinango et al (1976) who found that about 35% of the protamine sulfate tests carried out during labour were positive, a figure which in our studies reaches its maximum 6 hrs after the start of labour. Moreover, in a mixture of plasmas obtained from normal women during normal labour.…”

Section: Discussionsupporting

confidence: 87%

“…In fact, Kleiner (1975) has reported positive protamine sulphate tests in an increased percentage of cases only during labour. Arocha Pinango et al (1976) referred to an increase in positive protamine sulfate test during the first few hours of labour, but without establishing any correlation with the individual stages of labour itself, whilst Graeff et al (1973) and Bennett et al (1974) obtained no indications concerning the possible relationship between their results and the individual stages of labour.…”

Section: Introduction mentioning

confidence: 98%

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Alterations in the Coagulation and Fibrinolysis System in Pregnancy Labour and Puerperium, with Special Reference to a Possible Transitory State of Intravascular Coagulation during Labour

et al. 1978

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SummaryVarious tests of hemostasis were carried out during pregnancy, labour and the puerperium in a group of 259 women. Determinations were carried out in the 1st, 2nd and 3rd trimesters, in the period of dilatation, the expulsion period, the period of expulsion of the placenta and the immediate postpartum period of labour and on each of the first 5 days of the puerperium. It was confirmed that during pregnancy there is an elevation of the fibrinogen degradation producs (FDP) levels with a proportional increase in the numbers of positive protamine sulfate and ethanol tests. The proportion of positive protamine sulfate and ethanol tests reaches a maximum in the expulsion of the placenta coinciding with the presence of soluble complexes heavier than fibrinogen as detected by polyacrylamide gel electrophoresis and by column chromatography.All this indicates that there is a transitory intravascular coagulation produced during labour reaching its maximum at the time of birth and tending to become normalized in the first few days of the puerperium.

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Section: Discussionsupporting

confidence: 87%

Section: Introduction mentioning

confidence: 98%