Introduction to the thematic issue “From brain function to therapy”

Bartlett, Perry F.; He, Rong

doi:10.1007/s11427-014-4645-y

Cited by 3 publications

(1 citation statement)

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“…Tangles contain aggregated forms of the microtubule-associated Tau, which is hyperphosphorylated and accumulates intracellularly [ 13 , 14 ]. A lot of studies have been carried out to search for risk factors in the production and aggregation of Aβ and/or phosphorylated Tau (pTau) [ 15 ]. Mice do not develop senile plaques with Aβ deposition even as they age, nor do they develop neurofibrillary tangles [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice

Wei

Wang

et al. 2015

Oncotarget

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In addition to D-Glucose, D-Ribose is also abnormally elevated in the urine of type 2 diabetic patients, establishing a positive correlation between the concentration of uric D-Ribose and the severity of diabetes. Intraperitoneal injection of D-Ribose causes memory loss and brain inflammation in mice. To simulate a chronic progression of age-related cognitive impairment, we orally administered D-Ribose by gavage at both a low and high dose to 8 week-old male C57BL/6J mice daily for a total of 6 months, followed by behavioral, histological and biochemical analysis. We found that long-term oral administration of D-Ribose impairs spatial learning and memory, accompanied by anxiety-like behavior. Tau was hyperphosphorylated at AT8, S396, S214 and T181 in the brain. Aβ-like deposition was also found in the hippocampus for the high dose group. D-Glucose-gavaged mice did not show significant memory loss and anxiety-like behavior under the same experimental conditions. These results demonstrate that a long-term oral administration of D-Ribose not only induces memory loss with anxiety-like behavior, but also elevates Aβ-like deposition and Tau hyperphosphorylation, presenting D-Ribose-gavaged mouse as a model for age-related cognitive impairment and diabetic encephalopathy.

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