Inverted Papilloma

Abstract

Two hundred twenty-three cases of inverted papilloma seen at this institution over a 35-year period were reviewed. The number of cases steadily increased over each 5-year period. Common presenting signs and symptoms, association with carcinoma, and results of surgical and radiographic treatment are presented. The pathologic controversy surrounding this disease is discussed, and an argument is made for including all pathologic subtypes and septal, lateral wall, or sinus cases in a common clinical grouping of inverted papilloma. Lateral rhinotomy was found to be associated with fewer recurrences and a better probability of cure than lesser procedures and is recom mended as the standard surgical therapy. Radiotherapy was found to be a useful and effective adjunct in cases associated with malignancy or for multiply recurrent and inoperable benign inverted papillomas. Lifelong follow-up is urged.KEY WORDS -inverted papilloma, nasal cavity, papilloma, paranasal sinuses.

Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

“…There are some, however, who still consider these three lesions to be a single entity and group them together under such generic terms as papilloma, papillomatosis, or Schneiderian papilloma (3,4). Others are firmly convinced that there are sufficient clinical, pathological, and potential etiological differences among these papillomas to warrant their separation (5).…”

Papiloma invertido bilateral: relato de caso e revisão da literatura

“…The name inverted is justified by the endophilic growth of the superficial epithelium to inside the adjacent stroma 8,9,12 . This nasal epithelium proliferates and becomes metaplastic, originating many histological patterns (with internal microcysts) responsible for the high malignancy potential 8,12 .…”

“…This membrane would then suffer a number of structural changes, causing a greater predisposition for neoplastic differentiation 9,15 . Other possible etiologies are: inflammatory origin and/or chronic infectious rhinosinusitis, exposure to toxic substances, allergic processes, Epstein-Barr virus and Human Papilloma Virus (HPV) of subtypes 6, 11 and 167,10,11.…”

“…Tumor recurrence usually happens in the first two years; however, in 17% of the cases it happens after 6 years of evolution 6,9,15 , justifying patient follow up for at least 6 years 6,9,15 .…”

“…About 10% of he IP cases with cellular atypia are associated with squamous cells carcinoma [8][9][10][11][12] .…”