Investigating Functional DNA Grafted on Nanodiamond Surface Using Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy

Akiel, Rana D.; Zhang, Xiaojun; Abeywardana, Chathuranga; Stepanov, Viktor; Qin, Peter Z.; Takahashi, Susumu

doi:10.1021/acs.jpcb.6b00790

Cited by 28 publications

(25 citation statements)

References 42 publications

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“…Gaillard et al [42] used NHS-mediated amide bridges to bind NDs to peptide nuclei acids. Further approaches have focused on chopper-free click reactions with N 3 -functionalised NDs [43], DNA-biotin-avidin-biotin-ND origami [44], and DNA physisorption to NDs [45]. As an initial step of the proposed model, a facile conjugation of NDs to ssDNA as a platform for further immobilization on macroscopic surfaces is required.…”

Section: Resultsmentioning

confidence: 99%

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

et al. 2019

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Detonation nanodiamonds (NDs) are a novel class of carbon-based nanomaterials, and have received a great deal of attention in biomedical applications, due to their high biocompatibility, facile surface functionalization, and commercialized synthetic fabrication. We were able to transfer the NDs from large-size agglomerate suspensions to homogenous coatings. ND suspensions have been used in various techniques to coat on commercially available substrates of pure Ti and Si. Scanning electron microscopy (SEM) imaging and nanoindentation show that the densest and strongest coating of NDs was generated when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide (EDC/NHS)-mediated coupling to macroscopic silanized surfaces. In the next step, the feasibility of DNA-mediated coupling of NDs on macroscopic surfaces is discussed using fluorescent microscopy and additional particle size distribution, as well as zeta potential measurements. This work compares different ND coating strategies and describes the straightforward technique of grafting single-stranded DNA onto carboxylated NDs via thioester bridges.

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Section: Resultsmentioning

confidence: 99%

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

et al. 2019

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“…Versatility of click chemistry is further evident in that oligonucleotides can be bound to nanodiamonds (diamond crystals with sizes ranging from hundreds to a few nanometers) by introducing azide groups on their surface through chemical treatments. 140 The modified nanodiamonds are biocompatible and possess excellent chemical, mechanical, and photostability. 141,142 As described in the following sections in this review, click chemistry has been so widely used in a variety of areas (e.g., drug synthesis, biology, molecular biology, materials science, and others), and nowadays is regarded as an indispensible tool for science and technology (of course, for nanoarchitectonics).…”

Section: Dna Nanoarchitectonicsmentioning

confidence: 99%

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Komiyama

Yoshimoto

Sisido

et al. 2017

Bulletin of the Chemical Society of Japan

280

131

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In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA nanoarchitectonics and cellmacromolecular nanoarchitectonics, both of which are basically controlled by chemical strategies. The former DNA-based approach would represent the precise nature of the nanoarchitectonics based on the strict or "digital" molecular recognition between nucleic bases. This part includes functionalization of single DNAs by chemical means, modification of the main-chain or side-chain bases to achieve stronger DNA binding, DNA aptamers and DNAzymes. It also includes programmable assemblies of DNAs (DNA Origami) and their applications for delivery of drugs to target sites in vivo, sensing in vivo, and selective labeling of biomaterials in cells and in animals. In contrast to the digital molecular recognition between nucleic bases, cell membrane assemblies and their interaction with macromolecules are achieved through rather generic and "analog" interactions such as hydrophobic effects and electrostatic forces. This cell-macromolecular nanoarchitectonics is discussed in the latter part of this review. This part includes bottom-up and top-down approaches for constructing highly organized cell-architectures with macromolecules, for regulating cell adhesion pattern and their functions in twodimension, for generating three-dimensional cell architectures on micro-patterned surfaces, and for building synthetic/natural macromolecular modified hybrid biointerfaces.

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“…In another recent study, nanodimaonds were conjugated to a transforming growth factor via PEG‐streptavidin‐biotin and used for 3D particle tracking in cells in vivo ( Figure ). Single stranded DNA molecules were conjugated to nanodiamonds by Akiel et al using “click” chemistry.…”

Section: Bioconjugationmentioning

confidence: 99%

Near‐Infrared Fluorescent Nanomaterials for Bioimaging and Sensing

Reineck

Gibson

2016

Advanced Optical Materials

155

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A great challenge in noninvasive biomedical imaging is the acquisition of images inside a biological system at the cellular level. Common modalities used today such as magnetic resonance or computed tomography imaging have the advantage that any part of a living organism can be imaged at any depth, but are limited to millimeter resolution and can usually not be employed e.g., for surgical guidance. Optical imaging techniques offer resolution on the 100 nanometer scale, but are limited by the strong attenuation of visible light by biological matter and are traditionally used to image on the surface. Near‐infrared light in the “biological windows” can penetrate much deeper into biological samples, rendering fluorescence‐based imaging a viable alternative. In the past two decades, many fluorescent nanomaterials have been developed to operate in the near infrared, yet only few materials emitting above 1000 nm exist and none are approved for clinical use. This review describes recent advances in the development and use of near‐infrared fluorescent nanomaterials for biomedical imaging and sensing applications. The physical and chemical properties as well as the bioconjugation and application of materials such as organic fluorophores, semiconductor quantum dots, carbon‐based materials, rare earth materials, and polymer particles are discussed.

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Investigating Functional DNA Grafted on Nanodiamond Surface Using Site-Directed Spin Labeling and Electron Paramagnetic Resonance Spectroscopy

Cited by 28 publications

References 42 publications

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces

Chemistry Can Make Strict and Fuzzy Controls for Bio-Systems: DNA Nanoarchitectonics and Cell-Macromolecular Nanoarchitectonics

Near‐Infrared Fluorescent Nanomaterials for Bioimaging and Sensing

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