The Muhammadiyah University of Kupang (UMK) is famous as a pluralistic institution because this campus has Islamic ideology, but it is dominated by Christian students (75% Christian and 25% Moslem). The pluralism is increasingly strengthened through the vision of a multicultural institution as well as the application of multicultural education. The research was focused on the application of multicultural education to raise the pluralistic consciousness at the Muhamamdiyah University of Kupang. The study used qualitative research and purposive sampling to select subjects, namely Islamic, Protestant, Catholic students, and lecturers. The data was collected through in-depth interviews, observations, and field notes which were analyzed in one circle among data collection, categories, reading, noting, description, classification, interpretation, and visualization. The result of the study shows that implementation of multicultural education in UMK was divided in two approaches, namely (1) wisdom approach which consists of moral, social, and local wisdom carried out outside the class, and (2) the curriculum consists of contributions, additives, transformative approaches and social actions carried out in classes.