Irisin: A bridge between exercise and neurological diseases

Zhang, Yingjin; Zhang, Xuchang; ShiJun, Lin

doi:10.1016/j.heliyon.2022.e12352

Cited by 15 publications

(7 citation statements)

References 85 publications

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“…Irisin exhibited protection for the nervous system, which was observed in correlation with exercise. Different forms of exercise caused the irisin secretions at varying levels [24]. This study exhibited that HIIT increased the serum irisin levels.…”

Section: Discussionmentioning

confidence: 54%

Effects of acute and chronic high-intensity interval training on serum irisin, BDNF and apelin levels in male soccer referees

2024

Journal of Men's Health

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This study was aimed to investigate the effects of acute and chronic High Intensity Interval Training (HIIT) on Irisin, BDNF (brain-derived neurotrophic factor), and Apelin levels. The study included twenty-one male soccer referees. Blood from the participants was collected at the beginning of study (1. first measurement: baseline value). HIIT was conducted and blood was immediately collected (2. second measurement: acute effect). Next, HIIT was carried out for 20 minutes of 4 days a week in bouts of running (75 meters in 20 seconds) and walking (25 meters in 20 seconds). Blood was collected at the end of 12 weeks (3. third measurement: chronic effect). HIIT was performed and blood was again collected (4. fourth measurement: acute effect after the chronic effect). There was a gradual increase in irisin, BDNF, and apelin levels (p < 0.001). The increase for irisin was 2% in the second measurement, 106% in the third, and 111% in the fourth compared to the first measurement. The increase for BDNF was 39% in the second measurement, 116% in the third, and 133% in the fourth. Apelin levels were increased by 11%, 19%and 28%, respectively. These results demonstrated that irisin and BDNF might increase only in response to chronic HIIT (4 times a week) while apelin levels might change with both acute and chronic HIIT in healthy trained referees.

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Section: Discussionmentioning

confidence: 54%

Effects of acute and chronic high-intensity interval training on serum irisin, BDNF and apelin levels in male soccer referees

2024

Journal of Men's Health

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“…Skeletal muscle exercise induces expression of the myokine irisin, which linked to skeletal muscle mass and strength 32 , 33 . Evidence showed a bridge role between irisin and various neurodegenerative diseases, containing Alzheimer’s disease, Parkinson’s disease, and epilepsy 34 . Irisin level was positively correlated with hippocampal brain-derived neurotrophic factor levels, and hippocampal cell proliferation 35 .…”

Section: Discussionmentioning

confidence: 99%

Handgrip strength is associated with cognitive function in older patients with stage 3-5 chronic kidney disease: results from the NHANES

Zhang,

Wang,

Pang

et al. 2024

Sci Rep

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In this study, we aimed to investigate the association between handgrip strength (HGS) and cognitive performance in stage 3-5 chronic kidney disease (CKD) patients aged ≥ 60 years. This cross-sectional study analyzed data from National Health and Nutrition Examination Survey (NHANES) database 2011–2014. Three tests were used to assess the cognitive performance, including consortium to establish a registry for Alzheimer’s disease (CERAD), animal fluency test (AFT), and digit symbol substitution test (DSST). The multivariate linear regression analyses adjusting for confounding factors were utilized to evaluate the association of HGS with cognitive performance. A total of 678 older stage 3-5 CKD patients were included in this study. After adjusting for multiple factors, a higher HGS was positively associated with a higher CERAD-delayed recall and DSST score. In addition, our analysis indicated that HGS probably correlated with better performance of immediate learning ability in male, while working memory, sustained attention, and processing speed in female. HGS may be an important indicator for cognitive deficits in stage 3-5 CKD patients, especially for learning ability and executive function. Further research to explore the sex-specific and domain-specific and possible mechanisms are required.

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“…Therefore, CEP, which includes strength and cardiovascular training, could be a potent intervention for IS to increase muscle strength and cardiorespiratory endurance by improving irisin expression. Exercise intervention stimulates irisin secretion by contracting skeletal muscles ( 7 ). Animal experiments and clinical studies have shown that irisin plays a vital role in the nervous system through different biological mechanisms, including a positive effect on preventing neurological diseases and a potential therapeutic effect ( 20 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…Ischemic stroke (IS) accounts for 80% of stroke occurrences ( 6 ). Inadequate blood flow via brain vessels leads to impaired glucose supply, cerebral hypoxia, and impaired elimination of superfluous metabolites, ultimately leading to cerebral infarction ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The efficacy of community-based exercise programs on circulating irisin level, muscle strength, cardiorespiratory endurance, and body composition for ischemic stroke: a randomized controlled trial

2023

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ObjectiveWe investigated the changes in circulating irisin levels after community-based exercise and the association of these levels with improvements in muscle strength, cardiorespiratory endurance, and body composition in people with ischemic stroke.MethodsTwenty participants were randomly assigned to either a control or an exercise group. The community-based exercise program (CEP) consisted of 8 weeks of 1 h sessions for 3 days a week. Irisin levels, muscle strength, cardiorespiratory endurance, and body composition were assessed before and after the intervention.ResultsSignificant improvements were observed in the leg and trunk strength, peak oxygen consumption values, and body composition of the exercise group compared with the control group. In addition, circulating irisin levels were observed to have increased in the exercise group, positively correlated with muscle strength and cardiorespiratory endurance.ConclusionCEP might be an effective intervention to increase irisin levels and prevent a stroke-related decline in muscle function.

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Irisin: A bridge between exercise and neurological diseases

Cited by 15 publications

References 85 publications

Effects of acute and chronic high-intensity interval training on serum irisin, BDNF and apelin levels in male soccer referees

Effects of acute and chronic high-intensity interval training on serum irisin, BDNF and apelin levels in male soccer referees

Handgrip strength is associated with cognitive function in older patients with stage 3-5 chronic kidney disease: results from the NHANES

The efficacy of community-based exercise programs on circulating irisin level, muscle strength, cardiorespiratory endurance, and body composition for ischemic stroke: a randomized controlled trial

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