Is Mitochondrial Cell Fragility a Cell Weakness?

Abstract

Mitochondrial dysfunction has historically been linked to the cessation of cell function and ageing. Downstream effects such as reduced calcium buffering capacity, elevated levels of reactive oxygen species, and alterations in adenosine-5'-triphosphate are linked to a wide variety of pathological diseases. The importance of the mitochondria has increasingly been highlighted due to its potential as a therapeutic target for drug intervention and cell elimination in cancer. In addition, due to its origin, drugs targeting bacteria are required to be thoroughly tested prior to administration to prevent toxicity for the mitochondria. In this chapter, we will discuss a variety of factors that could influence mitochondrial dysfunction and highlight potential solutions to these. A comprehensive understanding regarding the mechanisms underlying mitochondrial dysfunction could aid in developing future therapeutic targets in multiple pathologies such as cancer and liver diseases.

Advanced Biological Imaging for Intracellular Micromanipulation: Methods and Applications

“…Fatigue-and experience-induced failures always occur and result in low operation success rates and large damage, thus degrading the performance of intracellular manipulation [22,23]. Generally, intracellular objects are fragile [24,25] and usually have irregular shapes [26,27], distribution [28,29], and small sizes [30,31]. For example, mitochondria in mammalian animals are usually less than 2 µm and randomly distribute among the cytoplasm [32].…”