Is sporadic Creutzfeldt‐Jakob disease transfusion‐transmissible?

Saá, Paula

doi:10.1111/trf.15763

Cited by 5 publications

(4 citation statements)

References 37 publications

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“…3,4 Thus, the consensus from these studies is that the risk, if any, of transfusion transmission of classic CJD is extremely low. [5][6][7] Of note, a report from the UK in 2017 shows sporadic CJD in two recipients of plasma products with long-term treatment, however a causal link to these products was not established. 8 The conclusion that CJD is unlikely to be transmitted by transfusion accompanies recognition that there is no longer significant risk of transmission of vCJD; the last reported transfusion transmission of vCJD worldwide was in 2007.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, comparable studies from the UK and Scandinavia found no cases among respectively 1194 and 7617 person years of observation, for an overall total of more than 15,500 person‐years 3,4 . Thus, the consensus from these studies is that the risk, if any, of transfusion transmission of classic CJD is extremely low 5–7 . Of note, a report from the UK in 2017 shows sporadic CJD in two recipients of plasma products with long‐term treatment, however a causal link to these products was not established 8 …”

Section: Discussionmentioning

confidence: 99%

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Absence of evidence of transfusion transmission risk of Creutzfeldt‐Jakob disease in the United States: Results froma 28‐year lookback study

Crowder,

Dodd,

Schonberger

2024

Transfusion

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BackgroundFor many years, there has been concern about the risk of transmission of classic forms of Creutzfeldt‐Jakob disease (CJD) by blood transfusion, particularly after the recognition of such transmission of variant CJD (vCJD). We report on a 28‐year lookback study of recipients of blood from donors who subsequently developed CJD.MethodsPatients with diagnosed CJD and a history of blood donation were identified. Blood centers were asked to provide information about the distribution of the donations and consignees were requested to provide information about the recipients of the donations. Vital status of each available recipient was determined and, if deceased, the reported cause(s) of death were obtained primarily from the National Death Index. All recipients included in the study database contributed person‐time up to the last recorded review of vital status.ResultsThere were 84 eligible donors who gave 3284 transfusable components, and it was possible to evaluate 1245 recipients, totaling 6495 person‐years of observation. The mean observation period per recipient was 5.5 years with a maximum of 51 years. No case of CJD or prion disease was reported among the recipient population.DiscussionThe study suggests that CJD may not be transfusion‐transmissible, a position in agreement with similar findings from two similar European reports amounting to an overall observation period of 15,500 person‐years. These studies have supported the conclusion that the risk, if any, of transmission of CJD by blood products is extremely small and remains theoretical.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Absence of evidence of transfusion transmission risk of Creutzfeldt‐Jakob disease in the United States: Results froma 28‐year lookback study

Crowder,

Dodd,

Schonberger

2024

Transfusion

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“…PrP TSE is present in plasma EVs of symptomatic and asymptomatic mice infected with prions (59, 60). Thus, via blood transfusion, EVs can contribute to recorded horizontal infection with variant CJD (61). The involvement of EVs in the oral pathway of infection is also possible since EVs can survive the stomach environment (62, 63).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Large Extracellular Vesicles Transfer Higher Levels of Prions and Infect Cell Culture Better than Small Extracellular Vesicles

Soukup

Mosko

Kereı̈che

et al. 2023

Preprint

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Prions are responsible for a number of lethal neurodegenerative and transmissible diseases in humans and animals. Extracellular vesicles, especially small exosomes, have been extensively studied in connection with various diseases. In contrast, larger microvesicles are often overlooked. In this work, we compared the ability of large extracellular vesicles (lEVs) and small extracellular vesicles (sEVs) to spread prions in cell culture. We utilized two cell culture models of prion infection and isolated lEVs by 20,000 × g force and sEVs by 110,000 × g force. The lEV fraction was enriched in β-1 integrin with a vesicle size starting at 150 nm. The fraction of sEVs was depleted of β-1 integrin with a mean size of 79 nm. Both fractions were enriched in prion protein, but the lEVs contained a higher prion-converting activity. In addition, lEV infection led to stronger prion signals in both cell cultures, as detected by cell and western blotting. Our data suggest the importance of lEVs in the trafficking and spread of prions over extensively studied small EVs.

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Large extracellular vesicles transfer more prions and infect cell culture better than small extracellular vesicles

Soukup,

Moško,

Kereïche

et al. 2023

Biochemical and Biophysical Research Communications

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Is sporadic Creutzfeldt‐Jakob disease transfusion‐transmissible?

Abstract: http://onlinelibrary.wiley.com/doi/10.1111/trf.15751/full

Cited by 5 publications

References 37 publications

Absence of evidence of transfusion transmission risk of Creutzfeldt‐Jakob disease in the United States: Results froma 28‐year lookback study

Absence of evidence of transfusion transmission risk of Creutzfeldt‐Jakob disease in the United States: Results froma 28‐year lookback study

Large Extracellular Vesicles Transfer Higher Levels of Prions and Infect Cell Culture Better than Small Extracellular Vesicles

Large extracellular vesicles transfer more prions and infect cell culture better than small extracellular vesicles

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