Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan

Simi, Silvana; Ballardin, Michela; Casella, Marta; Marchi, Daniele De; Hartwig, Valentina; Giovannetti, Giulio; Vanello, Nicola; Gabbriellini, S; Landini, Luigi; Lombardi, Massimo

doi:10.1016/j.mrfmmm.2008.08.011

Cited by 71 publications

(70 citation statements)

References 32 publications

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“…At the same time, CMR uses some of the strongest and fastest switching electromagnetic gradients available in MR imaging. 3,4 The amount of radiofrequency field energy delivered is defined as the specific absorption rate. Although long-term effects on human health from exposure to strong static magnetic fields seem unlikely, 5 acute effects such as vertigo, nausea, change in blood pressure, reversible arrhythmia, 6 and neurobehavioral effects have been documented from occupational exposure to 1.5 T. 7 Studies focusing on experimental teratogenic [8][9][10][11][12] or carcinogenic [13][14][15] effects of MR have demonstrated conflicting results.…”

Section: See Article By Lancellotti Et Almentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging

Kaufmann

2015

Circ: Cardiovascular Imaging

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Section: See Article By Lancellotti Et Almentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging

Kaufmann

2015

Circ: Cardiovascular Imaging

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“…However, some genotoxic effects of MRI scanning have been demonstrated under in vivo as well as in vitro conditions (Suzuki et al, 2001;Simi et al, 2008;Lee et al, 2011;Fiechter et al 2013). A recent review on safety of MRI has recommended a need for further studies as a precautionary principle (Hartwig et al, 2009).…”

Section: Genotoxic Effectsmentioning

confidence: 99%

An Update on Diagnostic Imaging Techniques in Veterinary Practice

Gugjoo¹,

Amarpal²,

Kinjavdekar³

et al. 2014

Adv. Anim. Vet. Sci.

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“…There are some studies on adverse health effects related to MRI (11)(12)(13)(14)(15)(16)(17)(18). Among the more recent work are two studies indicating a genotoxic potential of MRI in cell cultures (15;16).…”

Section: Introductionmentioning

confidence: 99%

No effects of MRI scan on male reproduction hormones

Mollerlokken

Moen

Baste

et al. 2012

Reproductive Toxicology

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This is an accepted version of a paper published in Reproductive Toxicology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the published paper: Møllerløkken, O., Moen, B., Baste, V., Magerøy, N., Oftedal, G. et al. (2012) "No effects of MRI scan on male reproduction hormones." Reproductive Toxicology URL: http://dx.doi.org/10. 1016/j.reprotox.2012.04.003 Access to the published version may require subscription. A prospective randomized balanced cross-over study using a head scan in real MRI with whole-body transmitting coil and sham MRI among 24 healthy male volunteers was conducted. Serum-blood samples of inhibin B, testosterone, prolactine, thyreotropine, luteinizing hormone, follicle stimulating hormone, sex-hormone binding globuline and estradiol were taken before and after the different scans. Neither immediately after, nor after 11 days were there seen any differences in the hormone levels comparing real and sham MRI. The lack of effects of EMF on male reproductive hormones should be reassuring to the public and especially for men examined in MRI. Adverse effects on other endpoints than male reproduction or possible chronic effect of multiple MRI scans have not been investigated in this study. Abstract (150 words)The use of mMagnetic resonance imaging (MRI) is increasing around the world and the possible adverse effects on reproductive health of electromagnetic fields (EMF) in MRI are not previously studied. We conducted aA prospective randomized balanced cross-over study using a head scan in real MRI with whole-body transmitting coil and sham MRI scan among 24 healthy male volunteers was conducted. Serum-blood samples of inhibin B, testosterone, prolactine, thyreotropine, luteinizing hormone, follicle stimulating hormone, sex-hormone binding globuline and estradiol were taken before and after the different scans. Neither immediately after, nor after 11 days were there seen any differences in the hormone levels comparing real and sham MRI. The lack of effects of EMF on male reproductive hormones should be reassuring to the public and especially for men examined in MRI. Adverse effects on other endpoints than male reproduction or possible chronic effect of multiple MRI scans have not been investigated in this study. Your reviewers have given us valuable comments which my coauthors and I hope to have addressed properly in this letter and in the revised manuscript. We have described our response in the letter and given reference to where in the revised manuscript the changes are. We have also highlighted the changed text in the revised manuscript.We hope you will consider this revised manuscript. Do not hesitate to contact me if anything is unclear. Thank you. Yours sincerelyOle Jacob Møllerløkken Institute of Public Health and Primary Health CareUniversity of Bergen Bergen -Norway *Response to Reviewer CommentsReviewer #1:This is an interesting manuscript with relevance to human patients. The authors conducted a randomized...

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Is the genotoxic effect of magnetic resonance negligible? Low persistence of micronucleus frequency in lymphocytes of individuals after cardiac scan

Cited by 71 publications

References 32 publications

Cardiac Magnetic Resonance Imaging

Cardiac Magnetic Resonance Imaging

An Update on Diagnostic Imaging Techniques in Veterinary Practice

No effects of MRI scan on male reproduction hormones

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