Isolation and Characterization of Flavonoids in Urena lobata Leaves

Singh, Dixa; Singh, Vimal Sheel

doi:10.9734/ejmp/2016/21502

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…Setiap tanaman mempunyai respon yang berbeda, ada beberapa tanaman yang peka terhadap penyinaran matahari langsung serta suhu yang terlalu tinggi [9]. Pengeringan yang tepat akan menghasilkan mutu simplisia yang baik sehingga tahan disimpan untuk waktu yang lama dan tidak terjadi perubahan bahan aktif yang dikandungnya [10]. Selain itu faktor yang mempengaruhi pengeringan antara lain sifat fisik dan kimia dari bahan tersebut meliputi bentuk, komposisi, ukuran dan kadar air didalamnya, kemudian sifat fisik lingkungan yang berhubungan dengan alat pengering yang digunakan selama proses pengeringan [11].…”

Section: Pendahuluanunclassified

The The Effect of Simplicia Drying Method on the Acquisition of Active Compound Levels of Grinting Grass Simplicia Extract (Cynodon dactylon (L.) Pers.)

2022

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The drying method is the most important step in maintaining levels active compound in the sample. This study aims to determine the effect drying method against levels of active compounds of grinting grass (Cynodon dactylon (L.) Pers.). Drying methods include sun drying and cabinet drayer. The results showed that the drying method in plants reduced the extractive gain from the levels of active compounds including flavonoids, polyphenols, steroids, terpenoids, alkaloids and saonins. Simplicia drying method gave a significant effect (p<0.05) on the extraction of the active compound content of grinting grass (Cynodon dactylon (L.) Pers.). Based on the two drying methods, the highest levels of active compound extractive were obtained in the cabinet drayer method compared to the drying method using sunlight.

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Section: Pendahuluanunclassified

The The Effect of Simplicia Drying Method on the Acquisition of Active Compound Levels of Grinting Grass Simplicia Extract (Cynodon dactylon (L.) Pers.)

2022

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“…Moreover, many studies have already reported that HRs accumulate phenolic compounds in amounts that lead to a significant increase in bioactivity that is comparable to, or even greater than, that present in intact plants or normal root cultures [30,31]. In fact, some flavonoids with potential bioactivity, such as quercetin and kaempferol, are found in Urena lobata [32,33]. In order to determine the appropriate time of application and types of precursor and elicitor that are appropriate for the enhancement of inhibitory activity, the duration of AHR culture was extended to up to 12 weeks, accompanied by the evaluation of DW, GIA, FLA, and PHEL.…”

Section: Kinetics Of Growth α-Glucosidase Inhibitory Activity and Pmentioning

confidence: 99%

Developing a Sufficient Protocol for the Enhancement of α-Glucosidase Inhibitory Activity by Urena lobata L. Aeroponic Hairy Roots Using Exogenous Factors, a Precursor, and an Elicitor

Cao

Hoang

et al. 2020

Plants

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Aeroponics is considered as a potential method for the culture of herbal plants due to the high growth rate, quantity and quality enhancement of secondary metabolites, and substantial environmental progress associated with this method. The aim of this study was to develop a sufficient protocol for successful Urena lobata hairy root induction by Agrobacterium rhizogenes ATCC 15834, using a precursor and elicitor to enhance α-glucosidase inhibitory activity (GIA) of aeroponic hairy roots (AHRs) in greenhouse conditions. In this study, we found that the optimized procedure (10 min, Woody plant medium (WPM), 1/25 salt strength) had an outstanding effect with a reduction in the rooting time (RT), promotion of the rooting rate (RR), and increase in the fresh weight (FW) and dry weight (DW) compared with the original procedure (30 min, Murashige and Skoog (MS) medium, 1/25 salt strength) after 30 days of culture. The highest DW, GIA, flavonoid (FLA) and phenolic (PHEL) contents were observed for individual addition of 10 mM phenylalanine (PA) or 50 mM chitosan (CS) in the late exponential phase (eighth week) with 15 days of elicitation compared to the control AHRs. However, individual treatment was less effective than the combination of the two. Positive correlations among the GIA, FLA and PHEL indicate that AHRs accumulated phenolic compounds, leading to an increase in the GIA by a synergistic effect. In conclusion, the culture of Urena lobata AHRs with PA and CS is an efficient procedure to produce GIA material in greenhouse conditions. The treatment of type II diabetes is sophisticated in terms of the variety of risk factors, one of which is the considerably rapid development of postprandial hyperglycemia [5]. Postprandial hyperglycemia occurs through the reaction of α-glucosidase and α-amylase in order to produce glucose. Therefore, by restricting or reducing the activity of these enzymes, the occurrence of postprandial hyperglycemia should decrease. The inhibition of α-glucosidase activity leads to a deterioration in disaccharide hydrolysis which has substantial long-term effects on glycemic index control in diabetic patients [6]. In recent years, natural medicines from plants have been used as useful treatments without any side effects.Hairy roots (HRs) are established from the interaction between Agrobacterium rhizogenes and the host plant (gene transformation from bacteria to the genome of the plant) [7]. There are numerous merits that accrue from the collaboration; in particular, a high growth rate without the dependence of any exogenous hormones, genetic stability, and a high branching rate. In addition, the ability to produce secondary metabolites remains stable. Hence, the HR cultural technique is considered to be an attractive substitute for the manufacture of tremendously valuable natural secondary metabolites instead of bud or callus cultures [8].Accompanied by the significant progress of modern techniques, aeroponics is a new method that has been adapted from classical hydroponics. Compared with hydropon...

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“…This plant is also known as Caesar weed, Congo jute, and Bachita, the local name varies from region to region. In Africa, the leaves and flowers of U. lobata could be eaten as food during famine time and the bast fiber of U. lobata is used as cordage material [2]. More interestingly, U. lobata is also commonly used in folk medicines for the treatment of diabetes, abdominal colic, malaria, gonorrhea, dysentery, fever, rheumatism, and edema [3,4].…”

Section: Introductionmentioning

confidence: 99%

Lignan Glycosides from Urena lobata

Luo

Ding

et al. 2019

Molecules

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Four new lignan glycosides; urenalignosides A–D (1–4), along with 12 known ones (5–16) were isolated from Urena lobata. Their structures were determined on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR; IR; CD; and HRESIMS). Compounds 2–4; 6; 7; 10; and 11 showed inhibition of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophage cells with IC50 values in the range of 25.5–98.4 μM (positive control; quercetin; IC50 = 7.2 ± 0.2 μM).

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Isolation and Characterization of Flavonoids in Urena lobata Leaves

Cited by 4 publications

References 3 publications

The The Effect of Simplicia Drying Method on the Acquisition of Active Compound Levels of Grinting Grass Simplicia Extract (Cynodon dactylon (L.) Pers.)

The The Effect of Simplicia Drying Method on the Acquisition of Active Compound Levels of Grinting Grass Simplicia Extract (Cynodon dactylon (L.) Pers.)

Developing a Sufficient Protocol for the Enhancement of α-Glucosidase Inhibitory Activity by Urena lobata L. Aeroponic Hairy Roots Using Exogenous Factors, a Precursor, and an Elicitor

Lignan Glycosides from Urena lobata

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