Isolierung von (+)‐Peganin aus der Geißraute, Galega officinalis L

Isolation and Characterization of Two Guanidines from Galega orientalis Lam. Cv. Gale (Fodder Galega)

“…The agronomic potential of the plant has been assessed for cooltemperate regions (Varis, 1986), and a proposal has been made by the Estonian Research Institute of Agriculture and Land Improvement to the International Seed Testing Association to have the species included in their list of field and forage crops under the name "fodder galega" (Raig, 1994). That common name was chosen to minimize confusion of G. orientalis with the other goat's rue, G. officinalis, which contains the guanidino-alkaloids galegine (1; Tanret, 1914;Spa ¨th and Prokopp, 1924) and 4-hydroxygalegine (2; Pufahl and Schreiber, 1961;Schreiber et al, 1964), and the pyrroloquinazoline vasicine (peganine, Schreiber et al, 1962). Of these components, galegine has been established as toxic to sheep (Gresham and Booth, 1991;Keeler et al, 1992Keeler et al, , 1986Huxtable et al, 1993).…”

Tricyclic Quinazoline Alkaloids: Isolation, Synthesis, Chemical Modification, and Biological Activity

“…Peganine N-oxide (6) was also isolated from N. komarovii [16]; 5-methoxypeganine (12), from Adhatoda vasica [17].…”

“…Optically active alkaloids (+)-peganine (3, vasicine), (-)-peganine (4), and their racemate (±)-peganine (5) were isolated from G. officinalis [12], N. komarovii [13], P. harmala [14], and Anisotes trisulcus [15]. Peganine N-oxide (6) was also isolated from N. komarovii [16]; 5-methoxypeganine (12), from Adhatoda vasica [17].…”